Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress–strain distribution on the aortic valve

This study developed a realistic 3D FSI computational model of the aortic valve using the fixed-grid method, which was eventually employed to investigate the effect of the leaflet thickness inhomogeneity and leaflet mechanical nonlinearity and anisotropy on the simulation results. The leaflet anisot...

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Main Authors:	Akram Joda, Zhongmin Jin, Axel Haverich, Jon Summers, Sotiris Korossis
Format:	Default Article
Published:	2016
Subjects:	Mechanical engineering not elsewhere classified Aortic valve Fluid–structure interaction Arbitrary Lagrangian Eulerian Anisotropic material model Mechanical Engineering not elsewhere classified Mechanical Engineering
Online Access:	https://hdl.handle.net/2134/37193
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id	rr-article-9565247
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spelling	rr-article-95652472016-03-05T00:00:00Z Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress–strain distribution on the aortic valve Akram Joda (6089384) Zhongmin Jin (192620) Axel Haverich (295514) Jon Summers (7212764) Sotiris Korossis (5214488) Mechanical engineering not elsewhere classified Aortic valve Fluid–structure interaction Arbitrary Lagrangian Eulerian Anisotropic material model Mechanical Engineering not elsewhere classified Mechanical Engineering This study developed a realistic 3D FSI computational model of the aortic valve using the fixed-grid method, which was eventually employed to investigate the effect of the leaflet thickness inhomogeneity and leaflet mechanical nonlinearity and anisotropy on the simulation results. The leaflet anisotropy and thickness inhomogeneity were found to significantly affect the valve stress–strain distribution. However, their effect on valve dynamics and fluid flow through the valve were minor. Comparison of the simulation results against in-vivo and in-vitro data indicated good agreement between the computational models and experimental data. The study highlighted the importance of simulating multi-physics phenomena (such as fluid flow and structural deformation), regional leaflet thickness inhomogeneity and anisotropic nonlinear mechanical properties, to accurately predict the stress–strain distribution on the natural aortic valve. 2016-03-05T00:00:00Z Text Journal contribution 2134/37193 https://figshare.com/articles/journal_contribution/Multiphysics_simulation_of_the_effect_of_leaflet_thickness_inhomogeneity_and_material_anisotropy_on_the_stress_strain_distribution_on_the_aortic_valve/9565247 CC BY-NC-ND 4.0
institution	Loughborough University
collection	Figshare
topic	Mechanical engineering not elsewhere classified Aortic valve Fluid–structure interaction Arbitrary Lagrangian Eulerian Anisotropic material model Mechanical Engineering not elsewhere classified Mechanical Engineering
spellingShingle	Mechanical engineering not elsewhere classified Aortic valve Fluid–structure interaction Arbitrary Lagrangian Eulerian Anisotropic material model Mechanical Engineering not elsewhere classified Mechanical Engineering Akram Joda Zhongmin Jin Axel Haverich Jon Summers Sotiris Korossis Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress–strain distribution on the aortic valve
description	This study developed a realistic 3D FSI computational model of the aortic valve using the fixed-grid method, which was eventually employed to investigate the effect of the leaflet thickness inhomogeneity and leaflet mechanical nonlinearity and anisotropy on the simulation results. The leaflet anisotropy and thickness inhomogeneity were found to significantly affect the valve stress–strain distribution. However, their effect on valve dynamics and fluid flow through the valve were minor. Comparison of the simulation results against in-vivo and in-vitro data indicated good agreement between the computational models and experimental data. The study highlighted the importance of simulating multi-physics phenomena (such as fluid flow and structural deformation), regional leaflet thickness inhomogeneity and anisotropic nonlinear mechanical properties, to accurately predict the stress–strain distribution on the natural aortic valve.
format	Default Article
author	Akram Joda Zhongmin Jin Axel Haverich Jon Summers Sotiris Korossis
author_facet	Akram Joda Zhongmin Jin Axel Haverich Jon Summers Sotiris Korossis
author_sort	Akram Joda (6089384)
title	Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress–strain distribution on the aortic valve
title_short	Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress–strain distribution on the aortic valve
title_full	Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress–strain distribution on the aortic valve
title_fullStr	Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress–strain distribution on the aortic valve
title_full_unstemmed	Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress–strain distribution on the aortic valve
title_sort	multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress–strain distribution on the aortic valve
publishDate	2016
url	https://hdl.handle.net/2134/37193
_version_	1797824183738040320

Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress–strain distribution on the aortic valve

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