Cellular senescence: immunosurveillance and future immunotherapy

In response to persistent DNA damage, induction into cell senescence promotes an immunogenic program which facilitates immune clearance of these damaged cells. Under physiological conditions, senescent cells can activate both innate and adaptive immune responses, functioning to maintain tissue homeo...

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Main Authors:	Dominick Burton, Alexandra Stolzing
Format:	Default Article
Published:	2018
Subjects:	Mechanical engineering not elsewhere classified Ageing Immunosurviellance Immunotherapy Macrophages Senescence Mechanical Engineering not elsewhere classified
Online Access:	https://hdl.handle.net/2134/31884
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id	rr-article-9563243
record_format	Figshare
spelling	rr-article-95632432018-02-07T00:00:00Z Cellular senescence: immunosurveillance and future immunotherapy Dominick Burton (4410355) Alexandra Stolzing (1251348) Mechanical engineering not elsewhere classified Ageing Immunosurviellance Immunotherapy Macrophages Senescence Mechanical Engineering not elsewhere classified In response to persistent DNA damage, induction into cell senescence promotes an immunogenic program which facilitates immune clearance of these damaged cells. Under physiological conditions, senescent cells can activate both innate and adaptive immune responses, functioning to maintain tissue homeostasis. In addition, emerging findings suggest that programmed induction of cell senescence may be important for regulating reproductive processes, partly facilitated by immune clearance. However, likely owing to ageing of the immune system, a failure to eliminate senescent cells can contribute to their persistence in tissues, leading to the development and progression of age-related diseases. Such immune failure may in part be due to activation of the senescence program in immune cells, leading to their dysfunction. Furthermore, senescent cells under certain biological contexts have been shown to instead promote immune suppression, a response that may reflect differences between an acute verses chronic senescent phenotype. In this review, we provide an overview of the research to date concerning senescence immunosurviellance, including a focused discussion on the mechanisms by which macrophages may recognise senescent cells. Senescence immunotherapy strategies as an alternative to senolytics for the removal of senescent cells will also be discussed. 2018-02-07T00:00:00Z Text Journal contribution 2134/31884 https://figshare.com/articles/journal_contribution/Cellular_senescence_immunosurveillance_and_future_immunotherapy/9563243 CC BY-NC-ND 4.0
institution	Loughborough University
collection	Figshare
topic	Mechanical engineering not elsewhere classified Ageing Immunosurviellance Immunotherapy Macrophages Senescence Mechanical Engineering not elsewhere classified
spellingShingle	Mechanical engineering not elsewhere classified Ageing Immunosurviellance Immunotherapy Macrophages Senescence Mechanical Engineering not elsewhere classified Dominick Burton Alexandra Stolzing Cellular senescence: immunosurveillance and future immunotherapy
description	In response to persistent DNA damage, induction into cell senescence promotes an immunogenic program which facilitates immune clearance of these damaged cells. Under physiological conditions, senescent cells can activate both innate and adaptive immune responses, functioning to maintain tissue homeostasis. In addition, emerging findings suggest that programmed induction of cell senescence may be important for regulating reproductive processes, partly facilitated by immune clearance. However, likely owing to ageing of the immune system, a failure to eliminate senescent cells can contribute to their persistence in tissues, leading to the development and progression of age-related diseases. Such immune failure may in part be due to activation of the senescence program in immune cells, leading to their dysfunction. Furthermore, senescent cells under certain biological contexts have been shown to instead promote immune suppression, a response that may reflect differences between an acute verses chronic senescent phenotype. In this review, we provide an overview of the research to date concerning senescence immunosurviellance, including a focused discussion on the mechanisms by which macrophages may recognise senescent cells. Senescence immunotherapy strategies as an alternative to senolytics for the removal of senescent cells will also be discussed.
format	Default Article
author	Dominick Burton Alexandra Stolzing
author_facet	Dominick Burton Alexandra Stolzing
author_sort	Dominick Burton (4410355)
title	Cellular senescence: immunosurveillance and future immunotherapy
title_short	Cellular senescence: immunosurveillance and future immunotherapy
title_full	Cellular senescence: immunosurveillance and future immunotherapy
title_fullStr	Cellular senescence: immunosurveillance and future immunotherapy
title_full_unstemmed	Cellular senescence: immunosurveillance and future immunotherapy
title_sort	cellular senescence: immunosurveillance and future immunotherapy
publishDate	2018
url	https://hdl.handle.net/2134/31884
_version_	1797190324246806528

Cellular senescence: immunosurveillance and future immunotherapy

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