Phosphorylation inhibits turnover of the tau protein by the proteasome: Influence of RCAN1 and oxidative stress

Phosphorylation inhibits turnover of the tau protein by the proteasome: Influence of RCAN1 and oxidative stress

Hyperphosphorylated tau proteins accumulate in the paired helical filaments of neurofibrillary tangles seen in such tauopathies as Alzheimer's disease. In the present paper we show that tau turnover is dependent on degradation by the proteasome (inhibited by MG132) in HT22 neuronal cells. Recom...

Full description

Saved in:
Bibliographic Details
Main Authors: Diana Poppek, Susi Keck, Gennady Ermak, Tobias Jung, Alexandra Stolzing, Oliver Ullrich, Kelvin J. A. Davies, Tilman Grune
Format: Default Article
Published: 2006
Subjects:
Mechanical engineering not elsewhere classified
Oxidative stress
Phosphorylation
Proteasome
RCAN1
Tau protein
Mechanical Engineering not elsewhere classified
Online Access:https://hdl.handle.net/2134/16864
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://hdl.handle.net/2134/16864

Similar Items