Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies

The aim of this study was to investigate the regional and directional differences in the biomechanics and histoarchitecture of the porcine mitral valve (MV) apparatus, with a view to tailoring tissue-engineered constructs for MV repair. The anterior leaflet displayed the largest directional anisotro...

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Main Authors: Nicholas Roberts, Lucrezia Morticelli, Zhongmin Jin, Eileen Ingham, Sotiris Korossis
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Published: 2015
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Online Access:https://hdl.handle.net/2134/37195
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spelling rr-article-95467462015-12-30T00:00:00Z Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies Nicholas Roberts (129471) Lucrezia Morticelli (7205276) Zhongmin Jin (192620) Eileen Ingham (482430) Sotiris Korossis (5214488) Mechanical engineering not elsewhere classified Mitral heart valve Mitral valve repair Mechanical anisotropy Stress–strain behavior Histology Mechanical Engineering not elsewhere classified Mechanical Engineering The aim of this study was to investigate the regional and directional differences in the biomechanics and histoarchitecture of the porcine mitral valve (MV) apparatus, with a view to tailoring tissue-engineered constructs for MV repair. The anterior leaflet displayed the largest directional anisotropy with significantly higher strength in the circumferential direction compared to the posterior leaflet. The histological results indicated that this was due to the circumferential alignment of the collagen fibers. The posterior leaflet demonstrated no significant directional anisotropy in the mechanical properties, and there was no significant directionality of the collagen fibers in the main body of the leaflet. The thinner commissural chordae were found to be significantly stiffer and less extensible than the strut chordae. Histological staining demonstrated a tighter knit of the collagen fibers in the commissural chordae than the strut chordae. By elucidating the inhomogeneity of the histoarchitecture and biomechanics of the MV apparatus, the results from this study will aid the regional differentiation of MV repair strategies, with tailored mitral-component-specific biomaterials or tissue-engineered constructs. 2015-12-30T00:00:00Z Text Journal contribution 2134/37195 https://figshare.com/articles/journal_contribution/Regional_biomechanical_and_histological_characterization_of_the_mitral_valve_apparatus_Implications_for_mitral_repair_strategies/9546746 CC BY-NC-ND 4.0
institution Loughborough University
collection Figshare
topic Mechanical engineering not elsewhere classified
Mitral heart valve
Mitral valve repair
Mechanical anisotropy
Stress–strain behavior
Histology
Mechanical Engineering not elsewhere classified
Mechanical Engineering
spellingShingle Mechanical engineering not elsewhere classified
Mitral heart valve
Mitral valve repair
Mechanical anisotropy
Stress–strain behavior
Histology
Mechanical Engineering not elsewhere classified
Mechanical Engineering
Nicholas Roberts
Lucrezia Morticelli
Zhongmin Jin
Eileen Ingham
Sotiris Korossis
Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies
description The aim of this study was to investigate the regional and directional differences in the biomechanics and histoarchitecture of the porcine mitral valve (MV) apparatus, with a view to tailoring tissue-engineered constructs for MV repair. The anterior leaflet displayed the largest directional anisotropy with significantly higher strength in the circumferential direction compared to the posterior leaflet. The histological results indicated that this was due to the circumferential alignment of the collagen fibers. The posterior leaflet demonstrated no significant directional anisotropy in the mechanical properties, and there was no significant directionality of the collagen fibers in the main body of the leaflet. The thinner commissural chordae were found to be significantly stiffer and less extensible than the strut chordae. Histological staining demonstrated a tighter knit of the collagen fibers in the commissural chordae than the strut chordae. By elucidating the inhomogeneity of the histoarchitecture and biomechanics of the MV apparatus, the results from this study will aid the regional differentiation of MV repair strategies, with tailored mitral-component-specific biomaterials or tissue-engineered constructs.
format Default
Article
author Nicholas Roberts
Lucrezia Morticelli
Zhongmin Jin
Eileen Ingham
Sotiris Korossis
author_facet Nicholas Roberts
Lucrezia Morticelli
Zhongmin Jin
Eileen Ingham
Sotiris Korossis
author_sort Nicholas Roberts (129471)
title Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies
title_short Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies
title_full Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies
title_fullStr Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies
title_full_unstemmed Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies
title_sort regional biomechanical and histological characterization of the mitral valve apparatus: implications for mitral repair strategies
publishDate 2015
url https://hdl.handle.net/2134/37195
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