Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies
The aim of this study was to investigate the regional and directional differences in the biomechanics and histoarchitecture of the porcine mitral valve (MV) apparatus, with a view to tailoring tissue-engineered constructs for MV repair. The anterior leaflet displayed the largest directional anisotro...
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rr-article-95467462015-12-30T00:00:00Z Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies Nicholas Roberts (129471) Lucrezia Morticelli (7205276) Zhongmin Jin (192620) Eileen Ingham (482430) Sotiris Korossis (5214488) Mechanical engineering not elsewhere classified Mitral heart valve Mitral valve repair Mechanical anisotropy Stress–strain behavior Histology Mechanical Engineering not elsewhere classified Mechanical Engineering The aim of this study was to investigate the regional and directional differences in the biomechanics and histoarchitecture of the porcine mitral valve (MV) apparatus, with a view to tailoring tissue-engineered constructs for MV repair. The anterior leaflet displayed the largest directional anisotropy with significantly higher strength in the circumferential direction compared to the posterior leaflet. The histological results indicated that this was due to the circumferential alignment of the collagen fibers. The posterior leaflet demonstrated no significant directional anisotropy in the mechanical properties, and there was no significant directionality of the collagen fibers in the main body of the leaflet. The thinner commissural chordae were found to be significantly stiffer and less extensible than the strut chordae. Histological staining demonstrated a tighter knit of the collagen fibers in the commissural chordae than the strut chordae. By elucidating the inhomogeneity of the histoarchitecture and biomechanics of the MV apparatus, the results from this study will aid the regional differentiation of MV repair strategies, with tailored mitral-component-specific biomaterials or tissue-engineered constructs. 2015-12-30T00:00:00Z Text Journal contribution 2134/37195 https://figshare.com/articles/journal_contribution/Regional_biomechanical_and_histological_characterization_of_the_mitral_valve_apparatus_Implications_for_mitral_repair_strategies/9546746 CC BY-NC-ND 4.0 |
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Mechanical engineering not elsewhere classified Mitral heart valve Mitral valve repair Mechanical anisotropy Stress–strain behavior Histology Mechanical Engineering not elsewhere classified Mechanical Engineering |
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Mechanical engineering not elsewhere classified Mitral heart valve Mitral valve repair Mechanical anisotropy Stress–strain behavior Histology Mechanical Engineering not elsewhere classified Mechanical Engineering Nicholas Roberts Lucrezia Morticelli Zhongmin Jin Eileen Ingham Sotiris Korossis Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies |
| description |
The aim of this study was to investigate the regional and directional differences in the biomechanics and histoarchitecture of the porcine mitral valve (MV) apparatus, with a view to tailoring tissue-engineered constructs for MV repair. The anterior leaflet displayed the largest directional anisotropy with significantly higher strength in the circumferential direction compared to the posterior leaflet. The histological results indicated that this was due to the circumferential alignment of the collagen fibers. The posterior leaflet demonstrated no significant directional anisotropy in the mechanical properties, and there was no significant directionality of the collagen fibers in the main body of the leaflet. The thinner commissural chordae were found to be significantly stiffer and less extensible than the strut chordae. Histological staining demonstrated a tighter knit of the collagen fibers in the commissural chordae than the strut chordae. By elucidating the inhomogeneity of the histoarchitecture and biomechanics of the MV apparatus, the results from this study will aid the regional differentiation of MV repair strategies, with tailored mitral-component-specific biomaterials or tissue-engineered constructs. |
| format |
Default Article |
| author |
Nicholas Roberts Lucrezia Morticelli Zhongmin Jin Eileen Ingham Sotiris Korossis |
| author_facet |
Nicholas Roberts Lucrezia Morticelli Zhongmin Jin Eileen Ingham Sotiris Korossis |
| author_sort |
Nicholas Roberts (129471) |
| title |
Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies |
| title_short |
Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies |
| title_full |
Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies |
| title_fullStr |
Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies |
| title_full_unstemmed |
Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies |
| title_sort |
regional biomechanical and histological characterization of the mitral valve apparatus: implications for mitral repair strategies |
| publishDate |
2015 |
| url |
https://hdl.handle.net/2134/37195 |
| _version_ |
1797279682443345920 |