Design and development of anisotropic laminate scaffolds of electrospun polycaprolactone for annulus fibrosus tissue engineering applications

In several cases, current therapies available to treat a large number of musculoskeletal system diseases are unsatisfactory as they provide only temporary or partial restoration of the damaged or degenerated site. In an attempt to maintain a high standard of life quality and minimise the economic lo...

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Main Author:	Andrea Fotticchia
Format:	Default Thesis
Published:	2016
Subjects:	Mechanical engineering not elsewhere classified Electrospinning Annulus fibrosus Tissue engineering Regenerative medicine Bioreactor Mesenchymal stem cells Intervertebral disc Mechanical Engineering not elsewhere classified
Online Access:	https://hdl.handle.net/2134/21407
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id	rr-article-9544067
record_format	Figshare
spelling	rr-article-95440672016-01-01T00:00:00Z Design and development of anisotropic laminate scaffolds of electrospun polycaprolactone for annulus fibrosus tissue engineering applications Andrea Fotticchia (7204088) Mechanical engineering not elsewhere classified Electrospinning Annulus fibrosus Tissue engineering Regenerative medicine Bioreactor Mesenchymal stem cells Intervertebral disc Mechanical Engineering not elsewhere classified In several cases, current therapies available to treat a large number of musculoskeletal system diseases are unsatisfactory as they provide only temporary or partial restoration of the damaged or degenerated site. In an attempt to maintain a high standard of life quality and minimise the economic losses due to the treatments of these frequently occurring ailments and subsequent lost working days, alternative therapies are being explored. Contrary to the current treatments, tissue engineering aims to regenerate the impaired tissue rather than repair and alleviate the symptoms; thus offering a definitive solution. The annulus fibrosus (AF) of the intervertebral disc (IVD) is a musculoskeletal system component frequently subjected to degeneration and rupture, characterised by predominance of anisotropically arranged collagen fibres. In the present thesis, electrospinning technology is used to fabricate polycaprolactone (PCL) scaffolds intended to replicate the anisotropic structure of the AF. [Continues.] 2016-01-01T00:00:00Z Text Thesis 2134/21407 https://figshare.com/articles/thesis/Design_and_development_of_anisotropic_laminate_scaffolds_of_electrospun_polycaprolactone_for_annulus_fibrosus_tissue_engineering_applications/9544067 CC BY-NC-ND 4.0
institution	Loughborough University
collection	Figshare
topic	Mechanical engineering not elsewhere classified Electrospinning Annulus fibrosus Tissue engineering Regenerative medicine Bioreactor Mesenchymal stem cells Intervertebral disc Mechanical Engineering not elsewhere classified
spellingShingle	Mechanical engineering not elsewhere classified Electrospinning Annulus fibrosus Tissue engineering Regenerative medicine Bioreactor Mesenchymal stem cells Intervertebral disc Mechanical Engineering not elsewhere classified Andrea Fotticchia Design and development of anisotropic laminate scaffolds of electrospun polycaprolactone for annulus fibrosus tissue engineering applications
description	In several cases, current therapies available to treat a large number of musculoskeletal system diseases are unsatisfactory as they provide only temporary or partial restoration of the damaged or degenerated site. In an attempt to maintain a high standard of life quality and minimise the economic losses due to the treatments of these frequently occurring ailments and subsequent lost working days, alternative therapies are being explored. Contrary to the current treatments, tissue engineering aims to regenerate the impaired tissue rather than repair and alleviate the symptoms; thus offering a definitive solution. The annulus fibrosus (AF) of the intervertebral disc (IVD) is a musculoskeletal system component frequently subjected to degeneration and rupture, characterised by predominance of anisotropically arranged collagen fibres. In the present thesis, electrospinning technology is used to fabricate polycaprolactone (PCL) scaffolds intended to replicate the anisotropic structure of the AF. [Continues.]
format	Default Thesis
author	Andrea Fotticchia
author_facet	Andrea Fotticchia
author_sort	Andrea Fotticchia (7204088)
title	Design and development of anisotropic laminate scaffolds of electrospun polycaprolactone for annulus fibrosus tissue engineering applications
title_short	Design and development of anisotropic laminate scaffolds of electrospun polycaprolactone for annulus fibrosus tissue engineering applications
title_full	Design and development of anisotropic laminate scaffolds of electrospun polycaprolactone for annulus fibrosus tissue engineering applications
title_fullStr	Design and development of anisotropic laminate scaffolds of electrospun polycaprolactone for annulus fibrosus tissue engineering applications
title_full_unstemmed	Design and development of anisotropic laminate scaffolds of electrospun polycaprolactone for annulus fibrosus tissue engineering applications
title_sort	design and development of anisotropic laminate scaffolds of electrospun polycaprolactone for annulus fibrosus tissue engineering applications
publishDate	2016
url	https://hdl.handle.net/2134/21407
_version_	1797736382934810624

Design and development of anisotropic laminate scaffolds of electrospun polycaprolactone for annulus fibrosus tissue engineering applications

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