Enzymatic fluorination of biotin and tetrazine conjugates for pretargeting approaches to positron emission tomography imaging

The use of radiolabelled antibodies and antibody-derived recombinant constructs has shown promise for both imaging and therapeutic use. In this context, the biotin–avidin/streptavidin pairing, along with the inverse-electron-demand Diels–Alder (iEDDA) reaction, have found application in pretargeting...

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Bibliographic Details
Main Authors: Phillip T. Lowe, Sergio Dall'Angelo, Andrew Devine, Matteo Zanda, David O'Hagan
Format: Default Article
Published: 2018
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Online Access:https://hdl.handle.net/2134/36580
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