Customisable 3D printed microfluidics for integrated analysis and optimisation

The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spec...

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Main Authors:	Tom Monaghan, Matthew Harding, Russell A. Harris, Ross J. Friel, Steven Christie
Format:	Default Article
Published:	2016
Subjects:	Mechanical engineering not elsewhere classified untagged Mechanical Engineering not elsewhere classified
Online Access:	https://hdl.handle.net/2134/22219
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id	rr-article-9390224
record_format	Figshare
spelling	rr-article-93902242016-07-18T00:00:00Z Customisable 3D printed microfluidics for integrated analysis and optimisation Tom Monaghan (1258749) Matthew Harding (1255161) Russell A. Harris (7150541) Ross J. Friel (7150544) Steven Christie (1256589) Mechanical engineering not elsewhere classified untagged Mechanical Engineering not elsewhere classified The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100–500 μm) means that these devices were capable of handling a wide range of concentrations (9 μM–38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels. 2016-07-18T00:00:00Z Text Journal contribution 2134/22219 https://figshare.com/articles/journal_contribution/Customisable_3D_printed_microfluidics_for_integrated_analysis_and_optimisation/9390224 CC BY-NC-ND 4.0
institution	Loughborough University
collection	Figshare
topic	Mechanical engineering not elsewhere classified untagged Mechanical Engineering not elsewhere classified
spellingShingle	Mechanical engineering not elsewhere classified untagged Mechanical Engineering not elsewhere classified Tom Monaghan Matthew Harding Russell A. Harris Ross J. Friel Steven Christie Customisable 3D printed microfluidics for integrated analysis and optimisation
description	The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100–500 μm) means that these devices were capable of handling a wide range of concentrations (9 μM–38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels.
format	Default Article
author	Tom Monaghan Matthew Harding Russell A. Harris Ross J. Friel Steven Christie
author_facet	Tom Monaghan Matthew Harding Russell A. Harris Ross J. Friel Steven Christie
author_sort	Tom Monaghan (1258749)
title	Customisable 3D printed microfluidics for integrated analysis and optimisation
title_short	Customisable 3D printed microfluidics for integrated analysis and optimisation
title_full	Customisable 3D printed microfluidics for integrated analysis and optimisation
title_fullStr	Customisable 3D printed microfluidics for integrated analysis and optimisation
title_full_unstemmed	Customisable 3D printed microfluidics for integrated analysis and optimisation
title_sort	customisable 3d printed microfluidics for integrated analysis and optimisation
publishDate	2016
url	https://hdl.handle.net/2134/22219
_version_	1796739441614651392

Customisable 3D printed microfluidics for integrated analysis and optimisation

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