Residues within the transmembrane domain of the glucagon-like peptide-1 receptor involved in ligand binding and receptor activation: modelling the ligand-bound receptor

The C-terminal regions of glucagon-like peptide-1 (GLP-1) bind to the N terminus of the GLP-1 receptor (GLP-1R), facilitating interaction of the ligand N terminus with the receptor transmembrane domain. In contrast, the agonist exendin-4 relies less on the transmembrane domain, and truncated antagon...

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Bibliographic Details
Main Authors: Karen Coopman, R. Wallis, G. Robb, A.J.H. Brown, Graeme F. Wilkinson, D. Timms, Gary B. Willars
Format: Default Article
Published: 2011
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Online Access:https://hdl.handle.net/2134/14779
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