Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming

Biodegradable poly(ε-caprolactone) (PCL) drug-carrier nanoparticles (NPs) were produced by rapid membrane micromixing combined with nanoprecipitation in a stirred cell employing novel membrane dispersion. The organic phase composed of 0.1−0.6 wt% PCL dissolved in tetrahydrofuran was injected into th...

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Main Authors:	Rahimah Othman, Goran Vladisavljevic, Hamed Shahmohamadi, Zoltan Nagy, Richard Holdich
Format:	Default Article
Published:	2016
Subjects:	Chemical engineering not elsewhere classified Membrane dispersion cell Computational fluid dynamics Nanoprecipitation Biodegradable polycaprolactone nanoparticles Microfabricated membrane Micromixing Chemical Engineering not elsewhere classified
Online Access:	https://hdl.handle.net/2134/21935
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id	rr-article-9241892
record_format	Figshare
spelling	rr-article-92418922016-01-01T00:00:00Z Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming Rahimah Othman (1254912) Goran Vladisavljevic (1253448) Hamed Shahmohamadi (1259757) Zoltan Nagy (1254105) Richard Holdich (1253271) Chemical engineering not elsewhere classified Membrane dispersion cell Computational fluid dynamics Nanoprecipitation Biodegradable polycaprolactone nanoparticles Microfabricated membrane Micromixing Chemical Engineering not elsewhere classified Biodegradable poly(ε-caprolactone) (PCL) drug-carrier nanoparticles (NPs) were produced by rapid membrane micromixing combined with nanoprecipitation in a stirred cell employing novel membrane dispersion. The organic phase composed of 0.1−0.6 wt% PCL dissolved in tetrahydrofuran was injected into the aqueous phase (Mili-Q water or 0.2−1 wt% poly(vinyl alcohol) using two microfabricated membranes with different pore morphologies and spatial pore arrangements: ringed stainless steel membrane of reduced (annular) operating area with a square array of cylindrical laser-drilled pores and electroformed nickel membrane of full operating area with a hexagonal array of conical, funnel-shaped pores. The size of the NPs was precisely controlled over a range of 159−394 nm by changing the aqueous-to-organic volumetric ratio, stirring rate, transmembrane flux, the polymer content in the organic phase, membrane type and pore size. The smallest and most uniform particles with a Z-average of 159 nm and a polydispersity index of 0.107±0.014 were obtained using a 10 μm pore-sized stainless steel membrane at the transmembrane flux of 140 L m-2 h-1, a stirring rate of 1,300 rpm, and an aqueous-to-organic phase volume ratio of 10 using 1 g L-1 PCL in the organic phase. The particle size decreased by increasing the stirring rate and the aqueous-to-organic volumetric ratio, and by decreasing the polymer concentration in the aqueous phase and the transmembrane flux. The existence of the peak shear stress within a transitional radius and a rapid decline of the shear stress away from the membrane surface were revealed by numerical modelling. 2016-01-01T00:00:00Z Text Journal contribution 2134/21935 https://figshare.com/articles/journal_contribution/Formation_of_size-tuneable_biodegradable_polymeric_nanoparticles_by_solvent_displacement_method_using_micro-engineered_membranes_fabricated_by_laser_drilling_and_electroforming/9241892 CC BY-NC-ND 4.0
institution	Loughborough University
collection	Figshare
topic	Chemical engineering not elsewhere classified Membrane dispersion cell Computational fluid dynamics Nanoprecipitation Biodegradable polycaprolactone nanoparticles Microfabricated membrane Micromixing Chemical Engineering not elsewhere classified
spellingShingle	Chemical engineering not elsewhere classified Membrane dispersion cell Computational fluid dynamics Nanoprecipitation Biodegradable polycaprolactone nanoparticles Microfabricated membrane Micromixing Chemical Engineering not elsewhere classified Rahimah Othman Goran Vladisavljevic Hamed Shahmohamadi Zoltan Nagy Richard Holdich Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming
description	Biodegradable poly(ε-caprolactone) (PCL) drug-carrier nanoparticles (NPs) were produced by rapid membrane micromixing combined with nanoprecipitation in a stirred cell employing novel membrane dispersion. The organic phase composed of 0.1−0.6 wt% PCL dissolved in tetrahydrofuran was injected into the aqueous phase (Mili-Q water or 0.2−1 wt% poly(vinyl alcohol) using two microfabricated membranes with different pore morphologies and spatial pore arrangements: ringed stainless steel membrane of reduced (annular) operating area with a square array of cylindrical laser-drilled pores and electroformed nickel membrane of full operating area with a hexagonal array of conical, funnel-shaped pores. The size of the NPs was precisely controlled over a range of 159−394 nm by changing the aqueous-to-organic volumetric ratio, stirring rate, transmembrane flux, the polymer content in the organic phase, membrane type and pore size. The smallest and most uniform particles with a Z-average of 159 nm and a polydispersity index of 0.107±0.014 were obtained using a 10 μm pore-sized stainless steel membrane at the transmembrane flux of 140 L m-2 h-1, a stirring rate of 1,300 rpm, and an aqueous-to-organic phase volume ratio of 10 using 1 g L-1 PCL in the organic phase. The particle size decreased by increasing the stirring rate and the aqueous-to-organic volumetric ratio, and by decreasing the polymer concentration in the aqueous phase and the transmembrane flux. The existence of the peak shear stress within a transitional radius and a rapid decline of the shear stress away from the membrane surface were revealed by numerical modelling.
format	Default Article
author	Rahimah Othman Goran Vladisavljevic Hamed Shahmohamadi Zoltan Nagy Richard Holdich
author_facet	Rahimah Othman Goran Vladisavljevic Hamed Shahmohamadi Zoltan Nagy Richard Holdich
author_sort	Rahimah Othman (1254912)
title	Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming
title_short	Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming
title_full	Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming
title_fullStr	Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming
title_full_unstemmed	Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming
title_sort	formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming
publishDate	2016
url	https://hdl.handle.net/2134/21935
_version_	1797736283780415488

Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming

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