A long nozzle for intra-nasal drug delivery by pMDI: prediction of spray velocity and droplet size

Intra-nasal drug delivery via nasal pressurized metered-dose inhalers (nasal-pMDI) is very successful in delivering treatment of conditions of the anterior regions of the human nasal cavity, such as rhinitis and sinusitis [1]. Intranasal drug delivery has also been postulated as a potential techniqu...

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Main Authors:	Barzin Gavtash, Hendrik Versteeg, Ben Myatt, Andy Cooper, Edward Long, Christopher Blatchford
Format:	Default Conference proceeding
Published:	2021
Subjects:	Pressurized Metered Dose Inhaler Intra-Nasal Drug Delivery Mathematical Modelling Digital Particle Image Velocimetry Laser Diffraction
Online Access:	https://hdl.handle.net/2134/19665465.v1
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id	rr-article-19665465
record_format	Figshare
spelling	rr-article-196654652021-05-04T00:00:00Z A long nozzle for intra-nasal drug delivery by pMDI: prediction of spray velocity and droplet size Barzin Gavtash (7200587) Hendrik Versteeg (1248945) Ben Myatt (12494617) Andy Cooper (7151621) Edward Long (1253967) Christopher Blatchford (12494618) Pressurized Metered Dose Inhaler Intra-Nasal Drug Delivery Mathematical Modelling Digital Particle Image Velocimetry Laser Diffraction <p>Intra-nasal drug delivery via nasal pressurized metered-dose inhalers (nasal-pMDI) is very successful in delivering treatment of conditions of the anterior regions of the human nasal cavity, such as rhinitis and sinusitis [1]. Intranasal drug delivery has also been postulated as a potential technique to treat central nervous system (CNS) diseases by delivering CNS-active drugs to the olfactory region – positioned at the upper region of the nasal cavity [1]. Our in-house in-vitro data suggest that the olfactory region can be targeted more accurately by extending the nasal pMDI nozzle length. Such nozzle length extension can potentially impact spray characteristics such as velocity, which directly determines the deposition efficiency [2]. In this work we report the development of a modeling tool validated by particle image velocimetry (PIV) and laser diffraction (LD) measurements, to predict the velocity and droplet size delivered from a long nozzle solution pMDI.</p> 2021-05-04T00:00:00Z Text Conference contribution 2134/19665465.v1 https://figshare.com/articles/conference_contribution/A_long_nozzle_for_intra-nasal_drug_delivery_by_pMDI_prediction_of_spray_velocity_and_droplet_size/19665465 CC BY-NC-ND 4.0
institution	Loughborough University
collection	Figshare
topic	Pressurized Metered Dose Inhaler Intra-Nasal Drug Delivery Mathematical Modelling Digital Particle Image Velocimetry Laser Diffraction
spellingShingle	Pressurized Metered Dose Inhaler Intra-Nasal Drug Delivery Mathematical Modelling Digital Particle Image Velocimetry Laser Diffraction Barzin Gavtash Hendrik Versteeg Ben Myatt Andy Cooper Edward Long Christopher Blatchford A long nozzle for intra-nasal drug delivery by pMDI: prediction of spray velocity and droplet size
description	Intra-nasal drug delivery via nasal pressurized metered-dose inhalers (nasal-pMDI) is very successful in delivering treatment of conditions of the anterior regions of the human nasal cavity, such as rhinitis and sinusitis [1]. Intranasal drug delivery has also been postulated as a potential technique to treat central nervous system (CNS) diseases by delivering CNS-active drugs to the olfactory region – positioned at the upper region of the nasal cavity [1]. Our in-house in-vitro data suggest that the olfactory region can be targeted more accurately by extending the nasal pMDI nozzle length. Such nozzle length extension can potentially impact spray characteristics such as velocity, which directly determines the deposition efficiency [2]. In this work we report the development of a modeling tool validated by particle image velocimetry (PIV) and laser diffraction (LD) measurements, to predict the velocity and droplet size delivered from a long nozzle solution pMDI.
format	Default Conference proceeding
author	Barzin Gavtash Hendrik Versteeg Ben Myatt Andy Cooper Edward Long Christopher Blatchford
author_facet	Barzin Gavtash Hendrik Versteeg Ben Myatt Andy Cooper Edward Long Christopher Blatchford
author_sort	Barzin Gavtash (7200587)
title	A long nozzle for intra-nasal drug delivery by pMDI: prediction of spray velocity and droplet size
title_short	A long nozzle for intra-nasal drug delivery by pMDI: prediction of spray velocity and droplet size
title_full	A long nozzle for intra-nasal drug delivery by pMDI: prediction of spray velocity and droplet size
title_fullStr	A long nozzle for intra-nasal drug delivery by pMDI: prediction of spray velocity and droplet size
title_full_unstemmed	A long nozzle for intra-nasal drug delivery by pMDI: prediction of spray velocity and droplet size
title_sort	long nozzle for intra-nasal drug delivery by pmdi: prediction of spray velocity and droplet size
publishDate	2021
url	https://hdl.handle.net/2134/19665465.v1
_version_	1797094806124494848

A long nozzle for intra-nasal drug delivery by pMDI: prediction of spray velocity and droplet size

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