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Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?

The precise mechanistic action of acetaminophen (ACT; paracetamol) remains debated. ACT’s analgesic and antipyretic actions are attributed to cyclooxygenase (COX) inhibition preventing prostaglandin (PG) synthesis. Two COX isoforms (COX1/2) share 60% sequence structure, yet their functions vary. COX...

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Bibliographic Details
Main Authors: Christopher J Esh, Bryna C. R. Chrismas, Alexis R. Mauger, Lee Taylor
Format: Default Article
Published: 2021
Subjects:
Online Access:https://hdl.handle.net/2134/16577489.v1
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