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Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?
The precise mechanistic action of acetaminophen (ACT; paracetamol) remains debated. ACT’s analgesic and antipyretic actions are attributed to cyclooxygenase (COX) inhibition preventing prostaglandin (PG) synthesis. Two COX isoforms (COX1/2) share 60% sequence structure, yet their functions vary. COX...
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Main Authors: | , , , |
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Format: | Default Article |
Published: |
2021
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Subjects: | |
Online Access: | https://hdl.handle.net/2134/16577489.v1 |
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