MicroRT—Small animal conformal irradiator

A novel small animal conformal radiation therapy system has been designed and prototyped: MicroRT. The microRT system integrates multimodality imaging, radiation treatment planning, and conformal radiation therapy that utilizes a clinical I 192 r isotope high dose rate source as the radiation source...

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Bibliographic Details
Published in:Medical physics (Lancaster) 2007-12, Vol.34 (12), p.4706-4716
Main Authors: Stojadinovic, S., Low, D. A., Hope, A. J., Vicic, M., Deasy, J. O., Cui, J., Khullar, D., Parikh, P. J., Malinowski, K. T., Izaguirre, E. W., Mutic, S., Grigsby, P. W.
Format: Article
Language:English
Subjects:
ACCURACY
Algorithms
ANIMALS
BEAM POSITION
cancer
COLLIMATORS
Computed tomography
Computer Simulation
Computer software
Conformal radiation therapy
Diseases
dosimetry
IRIDIUM 192
Iridium Radioisotopes - therapeutic use
MAGNETIC RESONANCE
Medical imaging
Medical treatment planning
Mice
microradiation therapy
microRT
microRTP
MONTE CARLO METHOD
Monte Carlo methods
NEOPLASMS
PLANNING
POSITRON COMPUTED TOMOGRAPHY
positron emission tomography
Positron emission tomography (PET)
Radiation Dosage
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIATION SOURCES
radiation therapy
Radiation therapy equipment
Radioisotope Teletherapy
RADIOLOGY AND NUCLEAR MEDICINE
RADIOTHERAPY
Radiotherapy sources
Radiotherapy, Conformal - instrumentation
small animal irradiation
TUNGSTEN
Water
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Summary:A novel small animal conformal radiation therapy system has been designed and prototyped: MicroRT. The microRT system integrates multimodality imaging, radiation treatment planning, and conformal radiation therapy that utilizes a clinical I 192 r isotope high dose rate source as the radiation source (teletherapy). A multiparameter dose calculation algorithm based on Monte Carlo dose distribution simulations is used to efficiently and accurately calculate doses for treatment planning purposes. A series of precisely machined tungsten collimators mounted onto a cylindrical collimator assembly is used to provide the radiation beam portals. The current design allows a source-to-target distance range of 1–8 cm at four beam angles: 0 ° (beam oriented down), 90 ° , 180 ° , and 270 ° . The animal is anesthetized and placed in an immobilization device with built-in fiducial markers and scanned using a computed tomography, magnetic resonance, or positron emission tomography scanner prior to irradiation. Treatment plans using up to four beam orientations are created utilizing a custom treatment planning system—microRTP. A three-axis computer-controlled stage that supports and accurately positions the animals is programmed to place the animal relative to the radiation beams according to the microRTP plan. The microRT system positioning accuracy was found to be submillimeter. The radiation source is guided through one of four catheter channels and placed in line with the tungsten collimators to deliver the conformal radiation treatment. The microRT hardware specifications, the accuracy of the treatment planning and positioning systems, and some typical procedures for radiobiological experiments that can be performed with the microRT device are presented.
ISSN:0094-2405
2473-4209
DOI:10.1118/1.2799887