Hemodynamic parameters obtained by transthoracic echocardiography and right heart catheterization： a comparative study in patients with pulmonary hypertension

Background Hemodynamic evaluation is crucial for the management of patients with pulmonary hypertention. Clinicians often prefer a rapid and non-invasive method. This study aimed to examine the feasibility of transthoracic echocardiography for the measurements of hemodynamic parameters in patients w...

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Published in:Chinese medical journal 2011-06, Vol.124 (12), p.1796-1801
Main Authors: Tian, Zhuang, Liu, Yong-Tai, Fang, Quan, Ni, Chao, Chen, Tai-Bo, Fang, Li-Gang, Gao, Peng, Jiang, Xiu-Chun, Li, Meng-Tao, Zeng, Xiao-Feng
Format: Article
Language:English
Subjects:
Adolescent
Adult
Cardiac Catheterization
Cardiac Output
Echocardiography
Female
Hemodynamics
Humans
Hypertension, Pulmonary - physiopathology
Male
Middle Aged
PASP
Prospective Studies
Pulmonary Wedge Pressure
动力学参数
导管
患者
检查
肺动脉高压
血流动力学
超声心动图
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container_issue 12
container_start_page 1796
container_title Chinese medical journal
container_volume 124
creator Tian, Zhuang
Liu, Yong-Tai
Fang, Quan
Ni, Chao
Chen, Tai-Bo
Fang, Li-Gang
Gao, Peng
Jiang, Xiu-Chun
Li, Meng-Tao
Zeng, Xiao-Feng
description Background Hemodynamic evaluation is crucial for the management of patients with pulmonary hypertention. Clinicians often prefer a rapid and non-invasive method. This study aimed to examine the feasibility of transthoracic echocardiography for the measurements of hemodynamic parameters in patients with pulmonary hypertension. Methods A prospective single-center study was conducted among 42 patients with pulmonary hypertension caused by different diseases. Transthoracic echocardiography and right-heart catheterization were performed within 24 hours. Pulmonary artery systolic, diastolic and mean pressure （PASP, PADP and PAMP）, cardiac output （CO）, and pulmonary capillary wedge pressure （PCWP） were measured by both methods. A linear correlation and a Bland-Altman analysis were performed to compare the two groups of hemodynamic parameters. Results A good correlation was found between invasive and non-invasive measurements for PASP （r=0.96）, PADP （r=0.85）, PAMP （r=0.88）, CO （r=0.82）, and PCWP （r=0.81）. Further agreement analysis done by the Bland-Altman method showed that bias and a 95% confidence interval for PASP, PADP, and CO were clinically acceptable while great discrepancies existed for PAMP and PCWP. Conclusions The non-invasive measurements by PASP, PADP, and CO in patients with pulmonary hypertension correlate well with the invasive determinations. Transthoracic echocardiography （TTE） was inappropriate for estimating PCWP and PAMP.
doi_str_mv 10.3760/cma.j.issn.0366-6999.2011.12.007
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Clinicians often prefer a rapid and non-invasive method. This study aimed to examine the feasibility of transthoracic echocardiography for the measurements of hemodynamic parameters in patients with pulmonary hypertension. Methods A prospective single-center study was conducted among 42 patients with pulmonary hypertension caused by different diseases. Transthoracic echocardiography and right-heart catheterization were performed within 24 hours. Pulmonary artery systolic, diastolic and mean pressure （PASP, PADP and PAMP）, cardiac output （CO）, and pulmonary capillary wedge pressure （PCWP） were measured by both methods. A linear correlation and a Bland-Altman analysis were performed to compare the two groups of hemodynamic parameters. Results A good correlation was found between invasive and non-invasive measurements for PASP （r=0.96）, PADP （r=0.85）, PAMP （r=0.88）, CO （r=0.82）, and PCWP （r=0.81）. Further agreement analysis done by the Bland-Altman method showed that bias and a 95% confidence interval for PASP, PADP, and CO were clinically acceptable while great discrepancies existed for PAMP and PCWP. Conclusions The non-invasive measurements by PASP, PADP, and CO in patients with pulmonary hypertension correlate well with the invasive determinations. Transthoracic echocardiography （TTE） was inappropriate for estimating PCWP and PAMP.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.3760/cma.j.issn.0366-6999.2011.12.007</identifier><identifier>PMID: 21740835</identifier><language>eng</language><publisher>China: Department of Cardiology,Peking Union Medical College Hospital, Beijing 100730, China%Department of Rheumatology ,Peking Union Medical College Hospital, Beijing 100730, China</publisher><subject>Adolescent ; Adult ; Cardiac Catheterization ; Cardiac Output ; Echocardiography ; Female ; Hemodynamics ; Humans ; Hypertension, Pulmonary - physiopathology ; Male ; Middle Aged ; PASP ; Prospective Studies ; Pulmonary Wedge Pressure ; 动力学参数 ; 导管 ; 患者 ; 检查 ; 肺动脉高压 ; 血流动力学 ; 超声心动图</subject><ispartof>Chinese medical journal, 2011-06, Vol.124 (12), p.1796-1801</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21740835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tian, Zhuang</creatorcontrib><creatorcontrib>Liu, Yong-Tai</creatorcontrib><creatorcontrib>Fang, Quan</creatorcontrib><creatorcontrib>Ni, Chao</creatorcontrib><creatorcontrib>Chen, Tai-Bo</creatorcontrib><creatorcontrib>Fang, Li-Gang</creatorcontrib><creatorcontrib>Gao, Peng</creatorcontrib><creatorcontrib>Jiang, Xiu-Chun</creatorcontrib><creatorcontrib>Li, Meng-Tao</creatorcontrib><creatorcontrib>Zeng, Xiao-Feng</creatorcontrib><title>Hemodynamic parameters obtained by transthoracic echocardiography and right heart catheterization： a comparative study in patients with pulmonary hypertension</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Background Hemodynamic evaluation is crucial for the management of patients with pulmonary hypertention. Clinicians often prefer a rapid and non-invasive method. This study aimed to examine the feasibility of transthoracic echocardiography for the measurements of hemodynamic parameters in patients with pulmonary hypertension. Methods A prospective single-center study was conducted among 42 patients with pulmonary hypertension caused by different diseases. Transthoracic echocardiography and right-heart catheterization were performed within 24 hours. Pulmonary artery systolic, diastolic and mean pressure （PASP, PADP and PAMP）, cardiac output （CO）, and pulmonary capillary wedge pressure （PCWP） were measured by both methods. A linear correlation and a Bland-Altman analysis were performed to compare the two groups of hemodynamic parameters. Results A good correlation was found between invasive and non-invasive measurements for PASP （r=0.96）, PADP （r=0.85）, PAMP （r=0.88）, CO （r=0.82）, and PCWP （r=0.81）. Further agreement analysis done by the Bland-Altman method showed that bias and a 95% confidence interval for PASP, PADP, and CO were clinically acceptable while great discrepancies existed for PAMP and PCWP. Conclusions The non-invasive measurements by PASP, PADP, and CO in patients with pulmonary hypertension correlate well with the invasive determinations. 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Clinicians often prefer a rapid and non-invasive method. This study aimed to examine the feasibility of transthoracic echocardiography for the measurements of hemodynamic parameters in patients with pulmonary hypertension. Methods A prospective single-center study was conducted among 42 patients with pulmonary hypertension caused by different diseases. Transthoracic echocardiography and right-heart catheterization were performed within 24 hours. Pulmonary artery systolic, diastolic and mean pressure （PASP, PADP and PAMP）, cardiac output （CO）, and pulmonary capillary wedge pressure （PCWP） were measured by both methods. A linear correlation and a Bland-Altman analysis were performed to compare the two groups of hemodynamic parameters. Results A good correlation was found between invasive and non-invasive measurements for PASP （r=0.96）, PADP （r=0.85）, PAMP （r=0.88）, CO （r=0.82）, and PCWP （r=0.81）. Further agreement analysis done by the Bland-Altman method showed that bias and a 95% confidence interval for PASP, PADP, and CO were clinically acceptable while great discrepancies existed for PAMP and PCWP. Conclusions The non-invasive measurements by PASP, PADP, and CO in patients with pulmonary hypertension correlate well with the invasive determinations. Transthoracic echocardiography （TTE） was inappropriate for estimating PCWP and PAMP.</notes><notes>hemodynamic; pulmonary hypertension; echocardiography; right heart catheterization</notes><notes>11-2154/R</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Background Hemodynamic evaluation is crucial for the management of patients with pulmonary hypertention. Clinicians often prefer a rapid and non-invasive method. This study aimed to examine the feasibility of transthoracic echocardiography for the measurements of hemodynamic parameters in patients with pulmonary hypertension. Methods A prospective single-center study was conducted among 42 patients with pulmonary hypertension caused by different diseases. Transthoracic echocardiography and right-heart catheterization were performed within 24 hours. Pulmonary artery systolic, diastolic and mean pressure （PASP, PADP and PAMP）, cardiac output （CO）, and pulmonary capillary wedge pressure （PCWP） were measured by both methods. A linear correlation and a Bland-Altman analysis were performed to compare the two groups of hemodynamic parameters. Results A good correlation was found between invasive and non-invasive measurements for PASP （r=0.96）, PADP （r=0.85）, PAMP （r=0.88）, CO （r=0.82）, and PCWP （r=0.81）. Further agreement analysis done by the Bland-Altman method showed that bias and a 95% confidence interval for PASP, PADP, and CO were clinically acceptable while great discrepancies existed for PAMP and PCWP. Conclusions The non-invasive measurements by PASP, PADP, and CO in patients with pulmonary hypertension correlate well with the invasive determinations. Transthoracic echocardiography （TTE） was inappropriate for estimating PCWP and PAMP.</abstract><cop>China</cop><pub>Department of Cardiology,Peking Union Medical College Hospital, Beijing 100730, China%Department of Rheumatology ,Peking Union Medical College Hospital, Beijing 100730, China</pub><pmid>21740835</pmid><doi>10.3760/cma.j.issn.0366-6999.2011.12.007</doi><tpages>6</tpages></addata></record>
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source HEAL-Link subscriptions: Lippincott Williams & Wilkins
subjects Adolescent
Adult
Cardiac Catheterization
Cardiac Output
Echocardiography
Female
Hemodynamics
Humans
Hypertension, Pulmonary - physiopathology
Male
Middle Aged
PASP
Prospective Studies
Pulmonary Wedge Pressure
动力学参数
导管
患者
检查
肺动脉高压
血流动力学
超声心动图
title Hemodynamic parameters obtained by transthoracic echocardiography and right heart catheterization： a comparative study in patients with pulmonary hypertension
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