Effect of curettage and copper wire on rabbit endometrium： a novel rabbit model of endometrial mechanical injury

Background It remains almost a helpless situation for the recurrent implantation failure and pregnancy loss caused by endometrial injury at present. The purpose of this study was to develop a rabbit model of endometrial mechanical injury that could provide a research platform for this difficult clin...

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Published in:Chinese medical journal 2011-06, Vol.124 (11), p.1708-1713
Main Authors: Li, Li, Shi, Jing, Zhang, Qiu-Fang, Yan, Jie, Yan, Li-Ying, Shen, Fei, Qiao, Jie, Feng, Huai-Liang
Format: Article
Language:English
Subjects:
Animals
Copper - adverse effects
Curettage - adverse effects
Disease Models, Animal
Endometrium - injuries
Female
Immunohistochemistry
Rabbits
子宫内膜
家兔
机械性损伤
模型
研究平台
组织学变化
膜损伤
铜线
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container_end_page 1713
container_issue 11
container_start_page 1708
container_title Chinese medical journal
container_volume 124
creator Li, Li
Shi, Jing
Zhang, Qiu-Fang
Yan, Jie
Yan, Li-Ying
Shen, Fei
Qiao, Jie
Feng, Huai-Liang
description Background It remains almost a helpless situation for the recurrent implantation failure and pregnancy loss caused by endometrial injury at present. The purpose of this study was to develop a rabbit model of endometrial mechanical injury that could provide a research platform for this difficult clinical predicament. Methods Three experiments were conducted. Experiment 1： Curettages in both uterus horns and copper wire inserting after curettage （double-injury） in one horn. The histological changes were monitored at 0, 24, 48, 72 hours, as well as in 1 and 2 weeks after operation. Experiment 2： Direct copper wire inserting in one horn and double-injury in other horn. The wires in both horns were removed after 2 weeks.
doi_str_mv 10.3760/cma.j.issn.0366-6999.2011.11.019
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The purpose of this study was to develop a rabbit model of endometrial mechanical injury that could provide a research platform for this difficult clinical predicament. Methods Three experiments were conducted. Experiment 1： Curettages in both uterus horns and copper wire inserting after curettage （double-injury） in one horn. The histological changes were monitored at 0, 24, 48, 72 hours, as well as in 1 and 2 weeks after operation. Experiment 2： Direct copper wire inserting in one horn and double-injury in other horn. 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injury; repair; animal model</notes><notes>Background It remains almost a helpless situation for the recurrent implantation failure and pregnancy loss caused by endometrial injury at present. 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language eng
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source HEAL-Link subscriptions: Lippincott Williams & Wilkins
subjects Animals
Copper - adverse effects
Curettage - adverse effects
Disease Models, Animal
Endometrium - injuries
Female
Immunohistochemistry
Rabbits
子宫内膜
家兔
机械性损伤
模型
研究平台
组织学变化
膜损伤
铜线
title Effect of curettage and copper wire on rabbit endometrium： a novel rabbit model of endometrial mechanical injury
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