Controlling the Release of bFGF from Silk Fibroin Membrane

Since neurotrophic factor is easy to degrade and aggregate, it usually has a short half-life in vitro. To overcome this shortage, neurotrophic factor has been combined with the silk fibroin （SF） membrane to realize less degradation, optimal loading efficiency, sustained release, and good adsorption....

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Bibliographic Details
Published in:Biomedical and environmental sciences 2014-12, Vol.27 (12), p.973-977
Main Authors: JI, Ya Wei, KONG, Yan, ZHAO, Ya Hong, WANG, Ya Ling, ZHAO, Jing, ZHANG, Lu Zhong, YANG, Yu Min
Format: Article
Language:English
Subjects:
Animals
bFGF
Cell Culture Techniques
Fibroblast Growth Factor 2 - chemistry
Fibroins - chemistry
PC12 Cells
Rats
丝素膜
丝素蛋白
半衰期
持续释放
控制
神经营养因子
装载效率
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Summary:Since neurotrophic factor is easy to degrade and aggregate, it usually has a short half-life in vitro. To overcome this shortage, neurotrophic factor has been combined with the silk fibroin （SF） membrane to realize less degradation, optimal loading efficiency, sustained release, and good adsorption.
ISSN:0895-3988
2214-0190
DOI:10.3967/bes2014.139