The Impact of Thyroid Function and TPOAb in the First Trimester on Pregnancy Outcomes: A Retrospective Study in Peking

Abstract Context The impact of mild TSH elevation (2.5–4.08 mIU/L) on pregnancy outcomes is unclear. The treatment strategy for mild TSH elevation is dependent on thyroid peroxidase antibody (TPOAb) status according to the guidelines. Objective To assess the effects of mild thyroid dysfunction combi...

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Bibliographic Details
Published in:	The journal of clinical endocrinology and metabolism 2020-03, Vol.105 (3), p.e368-e380
Main Authors:	Zhang, Yang, Sun, Weijie, Zhu, Sainan, Huang, Youyuan, Huang, Yu, Gao, Ying, Zhang, Junqing, Yang, Huixia, Guo, Xiaohui
Format:	Article
Language:	eng
Subjects:	Diabetes mellitus Iodide peroxidase Miscarriage Pregnancy Thyroid Thyroid gland Thyroid-stimulating hormone Thyroxine
Online Access:	Get full text
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Summary:	Abstract Context The impact of mild TSH elevation (2.5–4.08 mIU/L) on pregnancy outcomes is unclear. The treatment strategy for mild TSH elevation is dependent on thyroid peroxidase antibody (TPOAb) status according to the guidelines. Objective To assess the effects of mild thyroid dysfunction combined with TPOAb status in the first trimester on pregnancy outcomes and the impact of levothyroxine (L-T4) treatment on pregnancy outcomes. Design The study retrospectively evaluated 3562 pregnant women. A total of 3296 untreated women were divided into 4 subgroups: group A: 4.08 < TSH
ISSN:	0021-972X 1945-7197