Discordant orthostatic reflex renin-angiotensin and sympathoneural responses in premenopausal exercising-hypoestrogenic women

Discordant orthostatic reflex renin-angiotensin and sympathoneural responses in premenopausal exercising-hypoestrogenic women

Our prior observations in normotensive postmenopausal women stimulated the hypotheses that compared with eumenorrheic women, active hypoestrogenic premenopausal women with functional hypothalamic amenorrhea would demonstrate attenuated reflex renin-angiotensin-aldosterone system responses to an orth...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2015-05, Vol.65 (5), p.1089-1095
Main Authors: O'Donnell, Emma, Goodman, Jack M, Mak, Susanna, Murai, Hisayoshi, Morris, Beverley L, Floras, John S, Harvey, Paula J
Format: Article
Language:eng
Subjects:
Adolescent
Adult
Aldosterone - blood
Angiotensin II - blood
Blood Pressure - physiology
Estrogens - blood
Estrogens - deficiency
Exercise - physiology
Female
Follow-Up Studies
Humans
Posture - physiology
Premenopause - physiology
Reference Values
Reflex - physiology
Renin - blood
Renin-Angiotensin System - physiology
Sympathetic Nervous System - physiology
Young Adult
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Summary:Our prior observations in normotensive postmenopausal women stimulated the hypotheses that compared with eumenorrheic women, active hypoestrogenic premenopausal women with functional hypothalamic amenorrhea would demonstrate attenuated reflex renin-angiotensin-aldosterone system responses to an orthostatic challenge, whereas to defend blood pressure reflex increases in muscle, sympathetic nerve activity would be augmented. To test these hypotheses, we assessed, in recreationally active women, 12 with amenorrhea (ExFHA; aged 25 ± 1 years; body mass index 20.7 ± 0.7 kg/m(2); mean ± SEM) and 17 with eumenorrhea (ExOv; 24 ± 1 years; 20.9 ± 0.5 kg/m(2)), blood pressure, heart rate, plasma renin, angiotensin II, aldosterone, and muscle sympathetic nerve activity at supine rest and during graded lower body negative pressure (-10, -20, and -40 mm Hg). At baseline, heart rate and systolic blood pressure were lower (P0.05). In response to graded lower body negative pressure, heart rate increased (P
ISSN:0194-911X
1524-4563