Estradiol Induces Discordant Angiotensin and Blood Pressure Responses to Orthostasis in Healthy Postmenopausal Women

Postmenopausal estrogen replacement therapy (ERT) is reported to increase angiotensin II under resting conditions. To determine the implications of this increase for cardiovascular regulation during simulated orthostasis, blood pressure (BP), heart rate (HR), renin, angiotensinogen, angiotensin II,...

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Bibliographic Details
Published in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2005-03, Vol.45 (3), p.399-405
Main Authors:	Harvey, Paula J, Morris, Beverley L, Miller, Judith A, Floras, John S
Format:	Article
Language:	eng
Subjects:	Aldosterone - blood Angiotensin II - blood Angiotensinogen - blood Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - physiology Cardiology. Vascular system Case-Control Studies Clinical manifestations. Epidemiology. Investigative techniques. Etiology Estradiol - adverse effects Female Hemodynamics Hormones. Endocrine system Humans Lower Body Negative Pressure Medical sciences Middle Aged Pharmacology. Drug treatments Postmenopause Posture - physiology Renin - blood Renin-Angiotensin System
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Summary:	Postmenopausal estrogen replacement therapy (ERT) is reported to increase angiotensin II under resting conditions. To determine the implications of this increase for cardiovascular regulation during simulated orthostasis, blood pressure (BP), heart rate (HR), renin, angiotensinogen, angiotensin II, and aldosterone were measured at rest and during lower body negative pressure (LBNP; −10, −20, and −40 mm Hg). We studied 13 normotensive postmenopausal women (54±2 [mean±SE] years) before and after 1 month of oral estradiol 2 mg daily, and 14 premenopausal women. LBNP activated the renin-angiotensin system acutely in premenopausal but not postmenopausal women. Resting renin and aldosterone were unaffected by estradiol, whereas angiotensinogen (P
ISSN:	0194-911X 1524-4563