Electrogenic glucose absorption in untreated and treated coeliac disease

Using a method for measuring changes in transmural potential difference across the human jejunum in vivo, the operational kinetic parameters of 'Apparent Km' and PD max for the active electrogenic component of glucose absorption were estimated in a group of healthy volunteers and in patien...

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Bibliographic Details
Published in:	Gut 1976-06, Vol.17 (6), p.444-449
Main Authors:	Read, N W, Levin, R J, Holdsworth, C D
Format:	Article
Language:	eng
Subjects:	Celiac Disease - diet therapy Celiac Disease - metabolism Electrophysiology Female Glucose - metabolism Glutens Humans Intestinal Absorption Jejunum - metabolism Male
Online Access:	Get full text
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Summary:	Using a method for measuring changes in transmural potential difference across the human jejunum in vivo, the operational kinetic parameters of 'Apparent Km' and PD max for the active electrogenic component of glucose absorption were estimated in a group of healthy volunteers and in patients with coeliac disease. Both the 'Apparent Km' (17+/2mM; mean +/SEM) and the PD max (8.6+/0.7 mV) in nine patients with untreated coeliac disease were significantly lower (p less than 0.005) than in the control group ('Apparent Km' = 74+/5mM; PD max 12.8+/0.9mV, n=20). Treatment of five coeliac patients by gluten withdrawal for less than three months increased significantly the values of both the "Apparent Km (35+/6mM) and the TPD max (11.4+/1.2mV). Treatment of five patients for more than six months caused a further increase in the values of both kinetic parameters ('Apparent Km' = 108+/13mM; PD max =15.6+/2.7mV) to levels which exceeded those in healthy subjects. The possible interpretations of the differences in the kinetic characteristics of electrogenic glucose transport between coeliac patients and healthy subjects are discussed.
ISSN:	0017-5749 1468-3288