Randomised trial of early diet in preterm babies and later intelligence quotient

abstract Objectives: To determine whether perinatal nutrition influences cognitive function at 7 1/2 - 8 years in children born preterm. Design: Randomised, blinded nutritional intervention trial. Blinded follow up at 7 1/2 - 8 years. Setting: Intervention phase in two neonatal units; follow up in a...

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Bibliographic Details
Published in:	BMJ 1998-11, Vol.317 (7171), p.1481-1487
Main Authors:	Lucas, A, Morley, R, Cole, T J
Format:	Article
Language:	eng
Subjects:	Babies Biological and medical sciences Breast Feeding Breast milk Cerebral palsy Cerebral Palsy - psychology Child Child Development Child nutrition Children Clinical trials Cohort Studies Diet Dietary Supplements Experimentation Female Follow-Up Studies General and cellular metabolism. Vitamins Humans Infant Infant Food - analysis Infant Nutritional Physiological Phenomena Infant, Newborn Infant, Premature Infants Intelligence Intelligence quotient Male Malnutrition Medical sciences Nutrition Pharmacology. Drug treatments Sex Distribution
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Summary:	abstract Objectives: To determine whether perinatal nutrition influences cognitive function at 7 1/2 - 8 years in children born preterm. Design: Randomised, blinded nutritional intervention trial. Blinded follow up at 7 1/2 - 8 years. Setting: Intervention phase in two neonatal units; follow up in a clinic or school setting. Subjects: 424 preterm infants who weighed under 1850 g at birth; 360 of those who survived were tested at 7 1/2 - 8 years. Interventions: Standard infant formula versus nutrient enriched preterm formula randomly assigned as sole diet (trial A) or supplements to maternal milk (trial B) fed for a mean of 1 month. Main outcome measures: Intelligence quotient (IQ) at 7 1/2 - 8 years with abbreviated Weschler intelligence scale for children (revised). Results: There was a major sex difference in the impact of diet. At 7 1/2 - 8 years boys previously fed standard versus preterm formula as sole diet had a 12.2 point disadvantage (95% confidence interval 3.7 to 20.6; P
ISSN:	0959-8138 0959-8146 1468-5833 1756-1833