Indomethacin‐responsive headaches—A narrative review

Background Indomethacin is a nonsteroidal anti‐inflammatory drug whose mechanism of action in certain types of headache disorders remains unknown. The so‐called indomethacin‐responsive headache disorders consist of a group of conditions with a very different presentation that have a particularly goo...

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Bibliographic Details
Published in:	Headache 2021-05, Vol.61 (5), p.700-714
Main Authors:	Villar‐Martínez, Maria Dolores, Moreno‐Ajona, David, Chan, Calvin, Goadsby, Peter J.
Format:	Article
Language:	eng
Subjects:	Blood flow Blood pressure Cerebral blood flow Cough Disorders Headache Headaches hemicrania continua Indomethacin Inflammation Intracranial pressure Literature reviews Migraine paroxysmal hemicrania Pharmacodynamics Pharmacokinetics Pharmacology
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Summary:	Background Indomethacin is a nonsteroidal anti‐inflammatory drug whose mechanism of action in certain types of headache disorders remains unknown. The so‐called indomethacin‐responsive headache disorders consist of a group of conditions with a very different presentation that have a particularly good response to indomethacin. The response is so distinct as to be used in the definition of two: hemicrania continua and paroxysmal hemicrania. Methods This is a narrative literature review. PubMed and the Cochrane databases were used for the literature search. Results We review the main pharmacokinetic and pharmacodynamics properties of indomethacin useful for daily practice. The proposed mechanisms of action of indomethacin in the responsive headache disorders, including its effect on cerebral blood flow and intracranial pressure, with special attention to nitrergic mechanisms, are covered. The current evidence for its use in primary headache disorders, such as some trigeminal autonomic cephalalgias, cough, hypnic, exertional or sexual headache, and migraine will be covered, as well as its indication for secondary headaches, such as those of posttraumatic origin. Conclusion Increasing understanding of the mechanism(s) of action of indomethacin will enhance our understanding of the complex pathophysiology that might be shared by indomethacin‐sensitive headache disorders.
ISSN:	0017-8748 1526-4610