Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China

Background Coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS‐CoV‐2. Methods Electronic medical records includ...

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Bibliographic Details
Published in:	Allergy 2020-07, Vol.75 (7), p.1730-1741
Main Authors:	Zhang, Jin-jin, Dong, Xiang, Cao, Yi-yuan, Yuan, Ya-dong, Yang, Yi-bin, Yan, You-qin, Akdis, Cezmi A., Gao, Ya-dong
Format:	Article
Language:	eng
Subjects:	Adult Aged Aged, 80 and over Allergic diseases allergy Asthma Betacoronavirus - genetics C-Reactive Protein - analysis China - epidemiology Chronic obstructive pulmonary disease Community-Acquired Infections Comorbidity Coronavirus Infections - blood Coronavirus Infections - epidemiology Coronavirus Infections - physiopathology Coronavirus Infections - virology Coronaviruses Cough COVID-19 Demography Diabetes mellitus Diabetes Mellitus - epidemiology Electronic medical records Eosinopenia eosinophil Eosinophils Female Fever Hospitalization Humans Hypersensitivity Hypertension - epidemiology Infections Laboratories Leukocytes (eosinophilic) Lung diseases Lymphocytes Lymphopenia Male Middle Aged Obstructive lung disease Pandemics Patients Pneumonia, Viral - blood Pneumonia, Viral - epidemiology Pneumonia, Viral - physiopathology Pneumonia, Viral - virology Procalcitonin risk factor Risk Factors SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Urticaria
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Summary:	Background Coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS‐CoV‐2. Methods Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID‐19 patients, with confirmed result of SARS‐CoV‐2 viral infection, were extracted and analyzed. Results An approximately 1:1 ratio of male (50.7%) and female COVID‐19 patients was found, with an overall median age of 57.0 years. All patients were community‐acquired cases. Fever (91.7%), cough (75.0%), fatigue (75.0%), and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. Drug hypersensitivity (11.4%) and urticaria (1.4%) were self‐reported by several patients. Asthma or other allergic diseases were not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) patients and current smokers (1.4%) were rare. Bilateral ground‐glass or patchy opacity (89.6%) was the most common sign of radiological finding. Lymphopenia (75.4%) and eosinopenia (52.9%) were observed in most patients. Blood eosinophil counts correlate positively with lymphocyte counts in severe (r = .486, P
ISSN:	0105-4538 1398-9995