MO529: The Differential Effect of Third Generation Intravenous Iron Preparations (Ferric Carboxymaltose, Ferric Derisomaltose) on Patient Related Outcome Measures in Patients With Non-Dialysis Dependent CKD and Iron Deficiency Anaemia
Abstract BACKGROUND AND AIMS A frequent complication of chronic kidney disease (CKD) is iron deficiency anaemia. This affects not only patient mortality, morbidity and disease progression, but also quality of life. Patient-related outcome measures and functional status are important measures of asse...
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| Published in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2022-05, Vol.37 (Supplement_3) |
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| Main Authors: | , |
| Format: | Article |
| Language: | eng |
| Online Access: | Get full text |
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| Summary: | Abstract
BACKGROUND AND AIMS
A frequent complication of chronic kidney disease (CKD) is iron deficiency anaemia. This affects not only patient mortality, morbidity and disease progression, but also quality of life. Patient-related outcome measures and functional status are important measures of assessment in modern research. Evidence from patients with heart failure have demonstrated that treatment of iron deficiency leads to improved functional status, whilst in observational studies in non-dialysis dependent CKD (ND-CKD) iron replenishment has led to improvement in quality of life. As newer intravenous (IV) iron products [e.g. ferric carboxymaltose (FCM) and ferric derisomaltose (FDI)] are now in use, allowing efficacious and quick iron supplementation, a differential effect on phosphate has been noted. Phosphate is a key element involved in energy production and mitochondrial function. Therefore, the comparative effect between such compounds needs to be explored.
METHOD
The exploratory single-center double-blinded randomized controlled trial ‘Iron and Phosphaturia—ExplorIRON-CKD’ assessed the differential effects of FCM and FDI on fibroblast growth factor 23 and phosphate. Non-dialysis patients with CKD and iron deficiency with/without anaemia defined as serum ferritin |
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| ISSN: | 0931-0509 1460-2385 |