Height, adiposity and hormonal cardiovascular risk markers in childhood: how to partition the associations?

Obesity is associated with rapid growth during childhood. There is uncertainty over how to adjust for body size, when using adiposity as a proxy for cardiovascular risk. We studied associations of height, body composition (by dual-energy X-ray absorptiometry) and cardiovascular risk markers (insulin...

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Bibliographic Details
Published in:	International Journal of Obesity 2014-07, Vol.38 (7), p.930-935
Main Authors:	WELLS, J. C. K, COLE, T. J
Format:	Article
Language:	eng
Subjects:	Absorptiometry, Photon Adipose Tissue - metabolism Adiposity Adjustment Age Biological and medical sciences Biological markers Biomarkers - metabolism Body composition Body Mass Index Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - prevention & control Child Children Children & youth Childrens health Complications and side effects Cross-Sectional Studies Diseases Epidemiology Female General aspects Humans Insulin Resistance Investigations Leptin - metabolism Male Medical sciences Metabolic diseases Metabolism Nutrition research Nutritional status Obesity Obesity in children Original Pediatric Obesity - epidemiology Pediatric Obesity - metabolism Pediatric Obesity - prevention & control Pediatrics Puberty Risk Factors
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Summary:	Obesity is associated with rapid growth during childhood. There is uncertainty over how to adjust for body size, when using adiposity as a proxy for cardiovascular risk. We studied associations of height, body composition (by dual-energy X-ray absorptiometry) and cardiovascular risk markers (insulin resistance (IR), leptin) in children. Using partial correlations in 172 children aged 7-12 years, we investigated associations of (a) fat mass with IR or leptin, adjusting for height or lean mass, and (b) height or lean mass with IR or leptin, adjusting for fat mass. Analyses were conducted both cross-sectionally at each age, and for changes between 7 and 12 years. Height, fat mass, lean mass, IR and leptin were all inter-correlated at all ages. Although fat mass was strongly associated with IR and leptin, height was independently negatively associated with leptin (whole sample, adjusting for age: boys r=-0.12, girls r=-0.13; P
ISSN:	0307-0565 1476-5497