People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population

There is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current g...

Full description

Saved in:

Bibliographic Details
Published in:	European journal of human genetics : EJHG 2012-02, Vol.20 (2), p.203-210
Main Authors:	WINNEY, Bruce, BOUMERTIT, Abdelhamid, TONKS, Susan, XIAOFENG YANG, CHESHIRE, James, LONGLEY, Paul, MATEOS, Pablo, GROOM, Alexandra, RELTON, Caroline, TIM BISHOP, D, BLACK, Kathryn, NORTHWOOD, Emma, DAY, Tammy, PARKINSON, Louise, FRAYLING, Timothy M, STEELE, Anna, SAMPSON, Julian R, KING, Turi, DIXON, Ron, MIDDLETON, Derek, JENNINGS, Barbara, BOWDEN, Rory, DONNELLY, Peter, DAVISON, Dan, BODMER, Walter, ECHETA, Chikodi, EVSEEVA, Irina, HUTNIK, Katarzyna, LESLIE, Stephen, NICODEMUS, Kristin, ROYRVIK, Ellen C
Format:	Article
Language:	eng
Subjects:	Adolescent Adult Aged Aged, 80 and over Alleles Biological and medical sciences Birth Chromosomes College campuses Epidemiology Female Fundamental and applied biological sciences. Psychology Gene Frequency General aspects. Genetic counseling Genetics Genetics of eukaryotes. Biological and molecular evolution Genetics, Population Genomes Genotype Genotypes Genotyping Haplotypes Hospitals Humans Immigration Immunology Life Sciences Male Medical genetics Medical sciences Medicine Middle Aged Molecular and cellular biology Names Population Population - genetics Population structure Population studies Provenance Rural areas Studies United Kingdom Young Adult
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	There is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to have a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. In this study, we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK-control population that can be used as a resource by the research community, as well as providing a fine-scale genetic information on the British population. So far, some 4000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3 km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1057 samples demonstrates the value of these samples for investigating a fine-scale population structure within the UK, and shows how this can be enhanced by the use of surnames.
ISSN:	1018-4813 1476-5438