Photoredox-Catalyzed C–H Functionalization Reactions

Photoredox-Catalyzed C–H Functionalization Reactions

The fields of C–H functionalization and photoredox catalysis have garnered enormous interest and utility in the past several decades. Many different scientific disciplines have relied on C–H functionalization and photoredox strategies including natural product synthesis, drug discovery, radiolabelin...

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Bibliographic Details
Published in:Chemical reviews 2022-01, Vol.122 (2), p.1925-2016
Main Authors: Holmberg-Douglas, Natalie, Nicewicz, David A
Format: Article
Language:eng
Subjects:
Catalysis
Catalysts
Chemical reactions
Chemical synthesis
Fine chemicals
Natural products
Organic Chemicals
Photoredox catalysis
Radiolabelling
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Summary:The fields of C–H functionalization and photoredox catalysis have garnered enormous interest and utility in the past several decades. Many different scientific disciplines have relied on C–H functionalization and photoredox strategies including natural product synthesis, drug discovery, radiolabeling, bioconjugation, materials, and fine chemical synthesis. In this Review, we highlight the use of photoredox catalysis in C–H functionalization reactions. We separate the review into inorganic/organometallic photoredox catalysts and organic-based photoredox catalytic systems. Further subdivision by reaction classeither sp2 or sp3 C–H functionalizationlends perspective and tactical strategies for use of these methods in synthetic applications.
ISSN:0009-2665
1520-6890