Evaluate the effects of long-term valproic acid treatment on metabolic profiles in newly diagnosed or untreated female epileptic patients: A prospective study

Highlights • Valproic acid therapy should be used very cautionally in female epileptic patients who have higher BMI before therapy. • VPA therapy induces hypoadiponectinemia which correlates negatively with insulin resistance. • VPA-induced weight gain seems to be appetite-related rather than metabo...

Full description

Saved in:

Bibliographic Details
Published in:	Seizure (London, England) England), 2017-05, Vol.48, p.15-21
Main Authors:	Sidhu, Harpreet Singh, Srinivas, R, Sadhotra, Akshay
Format:	Article
Language:	eng
Subjects:	Adiponectin Adiponectin - blood Adiponectin - deficiency Adolescent Adult Anticonvulsants - adverse effects Anticonvulsants - therapeutic use Blood Glucose - analysis Body Mass Index Cholesterol - blood Cholesterol, HDL - blood Epilepsy - drug therapy Epilepsy - metabolism Female Humans Insulin Resistance Lamotrigine Metabolism, Inborn Errors - chemically induced Neurology Prospective Studies Sodium valproate Triazines - adverse effects Triazines - therapeutic use Triglycerides - blood Valproic Acid - adverse effects Valproic Acid - therapeutic use Weight Gain - drug effects Young Adult
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Highlights • Valproic acid therapy should be used very cautionally in female epileptic patients who have higher BMI before therapy. • VPA therapy induces hypoadiponectinemia which correlates negatively with insulin resistance. • VPA-induced weight gain seems to be appetite-related rather than metabolic.
ISSN:	1059-1311 1532-2688