Synthesis of 2,3-Diyne-1,4-naphthoquinone Derivatives and Evaluation of Cytotoxic Activity against Tumor Cell Lines

A series of 2,3-diyne-1,4-naphthoquinone derivatives was synthesized from 2,3-dibromo1,4-naphthoquinone and various functionalized terminal alkynes using palladium-catalyzed Sonogashira cross-coupling reaction. The diynes were evaluated as potential cytotoxic agents against three tumor cell lines: h...

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Published in:Journal of the Brazilian Chemical Society 2013-09, Vol.24 (9), p.1420-1426
Main Authors: Silva, Mauro G., Camara, Celso A., Silva, Tania M. S., Feitosa, Anderson C. S., Meira, Assuero S., Pessoa, Cláudia
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Language:eng ; por
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CHEMISTRY, MULTIDISCIPLINARY
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container_issue 9
container_start_page 1420
container_title Journal of the Brazilian Chemical Society
container_volume 24
creator Silva, Mauro G.
Camara, Celso A.
Silva, Tania M. S.
Feitosa, Anderson C. S.
Meira, Assuero S.
Pessoa, Cláudia
description A series of 2,3-diyne-1,4-naphthoquinone derivatives was synthesized from 2,3-dibromo1,4-naphthoquinone and various functionalized terminal alkynes using palladium-catalyzed Sonogashira cross-coupling reaction. The diynes were evaluated as potential cytotoxic agents against three tumor cell lines: human ovarian adenocarcinoma (OVCAR-8), human metastatic prostate cancer (PC-3M) and human bronchoalveolar lung carcinoma (NCI-H358M), presenting, in general, satisfactory results for inhibition of cell growth.
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title Synthesis of 2,3-Diyne-1,4-naphthoquinone Derivatives and Evaluation of Cytotoxic Activity against Tumor Cell Lines
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