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Cervical dystonia: clinical and therapeutic features in 85 patients
We studied patients with cervical dystonia (CD) to determine clinical features and response to botulinum toxin A (BoNT/A). Patients were submitted to clinical, laboratory and neuroimaging evaluation. BoNT/A was injected locally in 81 patients using electromyographic guidance. Four patients who had h...
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Published in: | Arquivos de neuro-psiquiatria 2008-03, Vol.66 (1), p.15-21 |
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creator | Camargo, Carlos Henrique F Teive, Hélio A G Becker, Nilson Baran, Maria Helena Herdoíza Scola, Rosana Hermínia Werneck, Lineu César |
description | We studied patients with cervical dystonia (CD) to determine clinical features and response to botulinum toxin A (BoNT/A). Patients were submitted to clinical, laboratory and neuroimaging evaluation. BoNT/A was injected locally in 81 patients using electromyographic guidance. Four patients who had had previous treatment were considered to be in remission. The average ages at onset of focal dystonia and segmental dystonia were greater than for generalized dystonia (p |
doi_str_mv | 10.1590/s0004-282x2008000100005 |
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Patients were submitted to clinical, laboratory and neuroimaging evaluation. BoNT/A was injected locally in 81 patients using electromyographic guidance. Four patients who had had previous treatment were considered to be in remission. The average ages at onset of focal dystonia and segmental dystonia were greater than for generalized dystonia (p<0.0003). The severity of the abnormal head-neck movements were more severe among the patients with generalized dystonia (p<0.001). Pain in the cervical area was noted in 59 patients. It was not possible to determine the etiology of the disease in 62.3% of patients. Tardive dystonia was the most common secondary etiology. A major improvement in the motor symptoms of CD and pain was observed in patients following treatment with BoNT/A. The tardive dystonia subgroup did not respond to the treatment. Dysphagia was observed in 2.35% of the patients.</description><identifier>ISSN: 0004-282X</identifier><identifier>ISSN: 1678-4227</identifier><identifier>EISSN: 1678-4227</identifier><identifier>EISSN: 0004-282X</identifier><identifier>DOI: 10.1590/s0004-282x2008000100005</identifier><identifier>PMID: 18392407</identifier><language>eng ; por</language><publisher>Brazil: Academia Brasileira de Neurologia - ABNEURO</publisher><subject>Adolescent ; Adult ; Aged ; Botulinum Toxins, Type A - adverse effects ; Botulinum Toxins, Type A - therapeutic use ; Child ; Child, Preschool ; Electromyography ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neuromuscular Agents - adverse effects ; Neuromuscular Agents - therapeutic use ; NEUROSCIENCES ; Pain Measurement ; PSYCHIATRY ; Severity of Illness Index ; Torticollis - drug therapy ; Treatment Outcome ; Young Adult</subject><ispartof>Arquivos de neuro-psiquiatria, 2008-03, Vol.66 (1), p.15-21</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-48ec8d2a5fe15ff18992a6db246ababcf72a58bc20737fb69fcad6b3496f72aa3</citedby><cites>FETCH-LOGICAL-c496t-48ec8d2a5fe15ff18992a6db246ababcf72a58bc20737fb69fcad6b3496f72aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,24178,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18392407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Camargo, Carlos Henrique F</creatorcontrib><creatorcontrib>Teive, Hélio A G</creatorcontrib><creatorcontrib>Becker, Nilson</creatorcontrib><creatorcontrib>Baran, Maria Helena Herdoíza</creatorcontrib><creatorcontrib>Scola, Rosana Hermínia</creatorcontrib><creatorcontrib>Werneck, Lineu César</creatorcontrib><title>Cervical dystonia: clinical and therapeutic features in 85 patients</title><title>Arquivos de neuro-psiquiatria</title><addtitle>Arq Neuropsiquiatr</addtitle><description>We studied patients with cervical dystonia (CD) to determine clinical features and response to botulinum toxin A (BoNT/A). Patients were submitted to clinical, laboratory and neuroimaging evaluation. BoNT/A was injected locally in 81 patients using electromyographic guidance. Four patients who had had previous treatment were considered to be in remission. The average ages at onset of focal dystonia and segmental dystonia were greater than for generalized dystonia (p<0.0003). The severity of the abnormal head-neck movements were more severe among the patients with generalized dystonia (p<0.001). Pain in the cervical area was noted in 59 patients. It was not possible to determine the etiology of the disease in 62.3% of patients. Tardive dystonia was the most common secondary etiology. A major improvement in the motor symptoms of CD and pain was observed in patients following treatment with BoNT/A. The tardive dystonia subgroup did not respond to the treatment. Dysphagia was observed in 2.35% of the patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Botulinum Toxins, Type A - adverse effects</subject><subject>Botulinum Toxins, Type A - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Electromyography</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuromuscular Agents - adverse effects</subject><subject>Neuromuscular Agents - therapeutic use</subject><subject>NEUROSCIENCES</subject><subject>Pain Measurement</subject><subject>PSYCHIATRY</subject><subject>Severity of Illness Index</subject><subject>Torticollis - drug therapy</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0004-282X</issn><issn>1678-4227</issn><issn>1678-4227</issn><issn>0004-282X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9UE1LxDAQDaK46-pf0J68dU3SjyTepPgFggcVvIVpmmCWbluTVNx_b-quiBcPwzAz783jPYTOCF6SQuALjzHOU8rpJ8WYx4HEwsUempOS8TSnlO2j-Q_odYaOvF9hTHMh2CGaEZ4JmmM2R1Wl3YdV0CbNxoe-s3CZqNZ23yvomiS8aQeDHoNVidEQRqd9YruEF8kAweou-GN0YKD1-mTXF-jl5vq5uksfHm_vq6uHVOWiDGnOteINhcJoUhhDuBAUyqameQk11MqweOO1ophlzNSlMAqass4ieTpBtkDL7V-vrG57uepH10VB-TQZlZPRP2lEwvmWMLj-fdQ-yLX1SrctdLofvaQRyHHJIpBtgcr13jtt5ODsGtxGEiynwP-RON1JjPVaN7-8XcLZF8Nbecs</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Camargo, Carlos Henrique F</creator><creator>Teive, Hélio A G</creator><creator>Becker, Nilson</creator><creator>Baran, Maria Helena Herdoíza</creator><creator>Scola, Rosana Hermínia</creator><creator>Werneck, Lineu César</creator><general>Academia Brasileira de Neurologia - ABNEURO</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>GPN</scope></search><sort><creationdate>20080301</creationdate><title>Cervical dystonia: clinical and therapeutic features in 85 patients</title><author>Camargo, Carlos Henrique F ; Teive, Hélio A G ; Becker, Nilson ; Baran, Maria Helena Herdoíza ; Scola, Rosana Hermínia ; Werneck, Lineu César</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-48ec8d2a5fe15ff18992a6db246ababcf72a58bc20737fb69fcad6b3496f72aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; por</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Botulinum Toxins, Type A - adverse effects</topic><topic>Botulinum Toxins, Type A - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Electromyography</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuromuscular Agents - adverse effects</topic><topic>Neuromuscular Agents - therapeutic use</topic><topic>NEUROSCIENCES</topic><topic>Pain Measurement</topic><topic>PSYCHIATRY</topic><topic>Severity of Illness Index</topic><topic>Torticollis - drug therapy</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Camargo, Carlos Henrique F</creatorcontrib><creatorcontrib>Teive, Hélio A G</creatorcontrib><creatorcontrib>Becker, Nilson</creatorcontrib><creatorcontrib>Baran, Maria Helena Herdoíza</creatorcontrib><creatorcontrib>Scola, Rosana Hermínia</creatorcontrib><creatorcontrib>Werneck, Lineu César</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>SciELO</collection><jtitle>Arquivos de neuro-psiquiatria</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Camargo, Carlos Henrique F</au><au>Teive, Hélio A G</au><au>Becker, Nilson</au><au>Baran, Maria Helena Herdoíza</au><au>Scola, Rosana Hermínia</au><au>Werneck, Lineu César</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cervical dystonia: clinical and therapeutic features in 85 patients</atitle><jtitle>Arquivos de neuro-psiquiatria</jtitle><addtitle>Arq Neuropsiquiatr</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>66</volume><issue>1</issue><spage>15</spage><epage>21</epage><pages>15-21</pages><issn>0004-282X</issn><issn>1678-4227</issn><eissn>1678-4227</eissn><eissn>0004-282X</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>We studied patients with cervical dystonia (CD) to determine clinical features and response to botulinum toxin A (BoNT/A). Patients were submitted to clinical, laboratory and neuroimaging evaluation. BoNT/A was injected locally in 81 patients using electromyographic guidance. Four patients who had had previous treatment were considered to be in remission. The average ages at onset of focal dystonia and segmental dystonia were greater than for generalized dystonia (p<0.0003). The severity of the abnormal head-neck movements were more severe among the patients with generalized dystonia (p<0.001). Pain in the cervical area was noted in 59 patients. It was not possible to determine the etiology of the disease in 62.3% of patients. Tardive dystonia was the most common secondary etiology. A major improvement in the motor symptoms of CD and pain was observed in patients following treatment with BoNT/A. The tardive dystonia subgroup did not respond to the treatment. Dysphagia was observed in 2.35% of the patients.</abstract><cop>Brazil</cop><pub>Academia Brasileira de Neurologia - ABNEURO</pub><pmid>18392407</pmid><doi>10.1590/s0004-282x2008000100005</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Aged Botulinum Toxins, Type A - adverse effects Botulinum Toxins, Type A - therapeutic use Child Child, Preschool Electromyography Female Follow-Up Studies Humans Male Middle Aged Neuromuscular Agents - adverse effects Neuromuscular Agents - therapeutic use NEUROSCIENCES Pain Measurement PSYCHIATRY Severity of Illness Index Torticollis - drug therapy Treatment Outcome Young Adult |
title | Cervical dystonia: clinical and therapeutic features in 85 patients |
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