Dynamic Contrast-Enhanced MRI Parameters and Normalized ADC Values Could Aid Differentiation of Skull Base Osteomyelitis from Nasopharyngeal Cancer

The skull base osteomyelitis sometimes can be difficult to distinguish from nasopharyngeal cancer. This study aimed to investigate the differences between skull base osteomyelitis and nasopharyngeal cancer using dynamic contrast-enhanced MR imaging and normalized ADC values. This study included 8 an...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2023-01, Vol.44 (1), p.74-78
Main Authors: Baba, A, Kurokawa, R, Kurokawa, M, Ota, Y, Srinivasan, A
Format: Article
Language:English
Subjects:
Contrast Media
Diffusion Magnetic Resonance Imaging - methods
Fellows' Journal Club
Functional
Head & Neck
Humans
Magnetic Resonance Imaging - methods
Nasopharyngeal Carcinoma - diagnostic imaging
Nasopharyngeal Neoplasms - diagnostic imaging
Osteomyelitis - diagnostic imaging
Retrospective Studies
Skull Base - diagnostic imaging
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Summary:The skull base osteomyelitis sometimes can be difficult to distinguish from nasopharyngeal cancer. This study aimed to investigate the differences between skull base osteomyelitis and nasopharyngeal cancer using dynamic contrast-enhanced MR imaging and normalized ADC values. This study included 8 and 12 patients with skull base osteomyelitis and nasopharyngeal cancer, respectively, who underwent dynamic contrast-enhanced MR imaging and DWI before primary treatment. Quantitative dynamic contrast-enhanced MR imaging parameters and ADC values of the ROIs were analyzed. Normalized ADC parameters were calculated by dividing the ROIs of the lesion by that of the spinal cord. The rate transfer constant between extravascular extracellular space and blood plasma per minute (Kep) was significantly lower in patients with skull base osteomyelitis than in those with nasopharyngeal cancer (median, 0.43 versus 0.57; = .04). The optimal cutoff value of Kep was 0.48 (area under the curve, 0.78; 95% CI, 0.55-1). The normalized mean ADC was significantly higher in patients with skull base osteomyelitis than in those with nasopharyngeal cancer (median, 1.90 versus 0.87;
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.A7740