Reduced Blood Coagulation on Roll-to-Roll, Shrink-Induced Superhydrophobic Plastics

The unique antiwetting properties of superhydrophobic (SH) surfaces prevent the adhesion of water and bodily fluids, including blood, urine, and saliva. While typical manufacturable approaches to create SH surfaces rely on chemical and structural modifications, such approaches are expensive, require...

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Published in:Advanced healthcare materials 2016-03, Vol.5 (5), p.593-601
Main Authors: Nokes, Jolie M., Liedert, Ralph, Kim, Monica Y., Siddiqui, Ali, Chu, Michael, Lee, Eugene K., Khine, Michelle
Format: Article
Language:English
Subjects:
Adhesion
Anticoagulants
anticoagulation
biomaterial
Blood
blood clotting
Blood coagulation
Blood Coagulation - drug effects
Clotting
Contact angle
Humans
Hydrophobic and Hydrophilic Interactions
Medical
Plastics - pharmacology
roll-to-roll manufacturing
Saliva
superhydrophobic
Surface Properties
Volatilization
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cited_by cdi_FETCH-LOGICAL-c6427-2a8a30bc0f08b3e8fc0840e199406f6f6bca16b6a5c8e61a0b54d827da9197173
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container_end_page 601
container_issue 5
container_start_page 593
container_title Advanced healthcare materials
container_volume 5
creator Nokes, Jolie M.
Liedert, Ralph
Kim, Monica Y.
Siddiqui, Ali
Chu, Michael
Lee, Eugene K.
Khine, Michelle
description The unique antiwetting properties of superhydrophobic (SH) surfaces prevent the adhesion of water and bodily fluids, including blood, urine, and saliva. While typical manufacturable approaches to create SH surfaces rely on chemical and structural modifications, such approaches are expensive, require postprocessing, and are often not biocompatible. By contrast, it is demonstrated that purely structural SH features are easily formed using high throughput roll‐to‐roll (R2R) manufacturing by shrinking a prestressed thermoplastic with a thin, stiff layer of silver and calcium. These features are subsequently embossed into any commercially available and Food and Drug Administration (FDA)‐approved plastic. The R2R SH surfaces have contact angles >150° and contact angle hysteresis 4200× reduction of blood residue area compared to the nonstructured controls of the same material. In addition, blood clotting is reduced >5× using whole blood directly from the patient. Furthermore, these surfaces can be easily configured into 3D shapes, as demonstrated with SH tubes. With the simple scale‐up production and the eliminated need for anticoagulants to prevent clotting, the proposed conformable SH surfaces can be impactful for a wide range of medical tools, including catheters and microfluidic channels. Superhydrophobic surfaces are achieved in a roll‐to‐roll platform by purely structural modification with no need for postprocessing. The biocompatible superhydrophobic hard plastic prevents water, blood, urine, and saliva from adhering to the surface, and blood slides off with no residue. Blood coagulation is significantly reduced on the superhydrophobic surface compared to flat, and superhydrophobic tubes are easily configured for medical applications.
doi_str_mv 10.1002/adhm.201500697
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While typical manufacturable approaches to create SH surfaces rely on chemical and structural modifications, such approaches are expensive, require postprocessing, and are often not biocompatible. By contrast, it is demonstrated that purely structural SH features are easily formed using high throughput roll‐to‐roll (R2R) manufacturing by shrinking a prestressed thermoplastic with a thin, stiff layer of silver and calcium. These features are subsequently embossed into any commercially available and Food and Drug Administration (FDA)‐approved plastic. The R2R SH surfaces have contact angles &gt;150° and contact angle hysteresis &lt;10°. Importantly, the surfaces minimize blood adhesion, leading to reduced blood coagulation without the need for anticoagulants. SH surfaces have &gt;4200× reduction of blood residue area compared to the nonstructured controls of the same material. In addition, blood clotting is reduced &gt;5× using whole blood directly from the patient. Furthermore, these surfaces can be easily configured into 3D shapes, as demonstrated with SH tubes. With the simple scale‐up production and the eliminated need for anticoagulants to prevent clotting, the proposed conformable SH surfaces can be impactful for a wide range of medical tools, including catheters and microfluidic channels. Superhydrophobic surfaces are achieved in a roll‐to‐roll platform by purely structural modification with no need for postprocessing. The biocompatible superhydrophobic hard plastic prevents water, blood, urine, and saliva from adhering to the surface, and blood slides off with no residue. 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Healthcare Mater</addtitle><description>The unique antiwetting properties of superhydrophobic (SH) surfaces prevent the adhesion of water and bodily fluids, including blood, urine, and saliva. While typical manufacturable approaches to create SH surfaces rely on chemical and structural modifications, such approaches are expensive, require postprocessing, and are often not biocompatible. By contrast, it is demonstrated that purely structural SH features are easily formed using high throughput roll‐to‐roll (R2R) manufacturing by shrinking a prestressed thermoplastic with a thin, stiff layer of silver and calcium. These features are subsequently embossed into any commercially available and Food and Drug Administration (FDA)‐approved plastic. The R2R SH surfaces have contact angles &gt;150° and contact angle hysteresis &lt;10°. Importantly, the surfaces minimize blood adhesion, leading to reduced blood coagulation without the need for anticoagulants. 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Healthcare Mater</addtitle><date>2016-03-09</date><risdate>2016</risdate><volume>5</volume><issue>5</issue><spage>593</spage><epage>601</epage><pages>593-601</pages><issn>2192-2640</issn><eissn>2192-2659</eissn><notes>ark:/67375/WNG-T7LWKQVQ-4</notes><notes>VTT Technical Research Centre of Finland</notes><notes>istex:0E715886969BD4ABBEBA3FCE1E9D3D614A07E6C0</notes><notes>Summer Undergraduate Research Program</notes><notes>National Institute of Health (NIH) Director's New Innovator Award - No. OD007283-01</notes><notes>ArticleID:ADHM201500697</notes><notes>industrial members of the Center for Advanced Design and Manufacturing of Integrated Microfluidics - No. IIP-1362165</notes><notes>National Science Foundation</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The unique antiwetting properties of superhydrophobic (SH) surfaces prevent the adhesion of water and bodily fluids, including blood, urine, and saliva. While typical manufacturable approaches to create SH surfaces rely on chemical and structural modifications, such approaches are expensive, require postprocessing, and are often not biocompatible. By contrast, it is demonstrated that purely structural SH features are easily formed using high throughput roll‐to‐roll (R2R) manufacturing by shrinking a prestressed thermoplastic with a thin, stiff layer of silver and calcium. These features are subsequently embossed into any commercially available and Food and Drug Administration (FDA)‐approved plastic. The R2R SH surfaces have contact angles &gt;150° and contact angle hysteresis &lt;10°. Importantly, the surfaces minimize blood adhesion, leading to reduced blood coagulation without the need for anticoagulants. SH surfaces have &gt;4200× reduction of blood residue area compared to the nonstructured controls of the same material. In addition, blood clotting is reduced &gt;5× using whole blood directly from the patient. Furthermore, these surfaces can be easily configured into 3D shapes, as demonstrated with SH tubes. With the simple scale‐up production and the eliminated need for anticoagulants to prevent clotting, the proposed conformable SH surfaces can be impactful for a wide range of medical tools, including catheters and microfluidic channels. Superhydrophobic surfaces are achieved in a roll‐to‐roll platform by purely structural modification with no need for postprocessing. The biocompatible superhydrophobic hard plastic prevents water, blood, urine, and saliva from adhering to the surface, and blood slides off with no residue. Blood coagulation is significantly reduced on the superhydrophobic surface compared to flat, and superhydrophobic tubes are easily configured for medical applications.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>26784916</pmid><doi>10.1002/adhm.201500697</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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source Wiley Online Library
subjects Adhesion
Anticoagulants
anticoagulation
biomaterial
Blood
blood clotting
Blood coagulation
Blood Coagulation - drug effects
Clotting
Contact angle
Humans
Hydrophobic and Hydrophilic Interactions
Medical
Plastics - pharmacology
roll-to-roll manufacturing
Saliva
superhydrophobic
Surface Properties
Volatilization
title Reduced Blood Coagulation on Roll-to-Roll, Shrink-Induced Superhydrophobic Plastics
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