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Prognostic significance of hsa_circ_0048122 to predict liver metastasis in early‐stage colorectal cancer
Background Liver metastasis is the primary cause of lethal colorectal cancer (CRC). The predominant risk of poor patient prognosis in early‐stage CRC emerges as metachronous liver metastasis. This necessitates the search for potential biomarkers for this metastasis to assess treatment outcomes and p...
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| Published in: | Journal of clinical laboratory analysis 2022-08, Vol.36 (8), p.e24577-n/a |
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| creator | Fang, Qian Ni, Chuandou Cai, Zhun Li, Wangyong Xie, Jianjin |
| description | Background
Liver metastasis is the primary cause of lethal colorectal cancer (CRC). The predominant risk of poor patient prognosis in early‐stage CRC emerges as metachronous liver metastasis. This necessitates the search for potential biomarkers for this metastasis to assess treatment outcomes and provide targeted therapy.
Methods
The role of hsa_circ_0048122 in predicting liver metastasis in CRC was probed in this work. This retrospective and multi‐center investigation entailed exploration and identification stages with 158 and 176 patients. While RT‐qPCR was employed to scrutinize hsa_circ_0048122 expression, Kaplan–Meier survival, and multivariate analyses were used to probe its prognostic impact in early‐stage CRC and stage IV CRC cases, respectively.
Results
A strong correlation between liver metastases and hsa_circ_0048122 expression in stage IV CRC patients with a high hsa_circ_0048122 profile indicated a poor overall survival. Likewise, a high expression level of hsa_circ_0048122 appears as a potential predictor of liver metastases in patients' initial stages.
Conclusions
Predicting liver metastasis can be plausibly facilitated using Hsa_circ_0048122 as a biomarker in early‐stage CRC cases.
Figure 1. Profiling of circRNAs from the CRCLM patients. (A) Volcano plot of differentially expressed genes in GEO datasets GSE147597. (B) Mean‐difference plot in GEO datasets GSE147597. (C) Venn diagram analysis of differentially expressed genes. (D) Hsa_circ_0048122 is upregulated in NSCLC compared to adjacent normal tissues. |
| doi_str_mv | 10.1002/jcla.24577 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9396183</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2705224986</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4257-d7e817e4f649f6afb5063b9aced63c9b15217a94a78cc9fe443d63088ac3388c3</originalsourceid><addsrcrecordid>eNp9kc1qVEEQhRsxmEl04xM0uBHhJv13-2cjhEGNMqALXTc9NXUnPfTcHrvvJMzOR_AZfRI7mSDoQigoqPPVoYpDyEvOLjhj4nIDKVwI1RvzhMw4c7YTVvRPyYxZazrLuDwlZ7VuGGPWcf2MnMreOMGUnJHNl5LXY65TBFrjeoxDhDAC0jzQmxo8xAKeMWW5EHTKdFdwFWGiKd5ioVucQm0VK40jxVDS4dePn22yRgo55YIwhUQfHMtzcjKEVPHFYz8n396_-zq_7hafP3ycXy06UKI33cqg5QbVoJUbdBiWPdNy6QLgSktwS94LboJTwVgAN6BSsgnt1QBSWgvynLw9-u72yy2uAMephOR3JW5DOfgcov9bGeONX-db76TT3Mpm8PrRoOTve6yT38YKmFIYMe-rF9r2ShmhWUNf_YNu8r6M7T0vDOuFUM7qRr05UlByrQWHP8dw5u8j9PcR-ocIG8yP8F1MePgP6T_NF1fHnd8HBJ7u</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2705224986</pqid></control><display><type>article</type><title>Prognostic significance of hsa_circ_0048122 to predict liver metastasis in early‐stage colorectal cancer</title><source>Open Access: Wiley-Blackwell Open Access Journals</source><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Fang, Qian ; Ni, Chuandou ; Cai, Zhun ; Li, Wangyong ; Xie, Jianjin</creator><creatorcontrib>Fang, Qian ; Ni, Chuandou ; Cai, Zhun ; Li, Wangyong ; Xie, Jianjin</creatorcontrib><description>Background
Liver metastasis is the primary cause of lethal colorectal cancer (CRC). The predominant risk of poor patient prognosis in early‐stage CRC emerges as metachronous liver metastasis. This necessitates the search for potential biomarkers for this metastasis to assess treatment outcomes and provide targeted therapy.
Methods
The role of hsa_circ_0048122 in predicting liver metastasis in CRC was probed in this work. This retrospective and multi‐center investigation entailed exploration and identification stages with 158 and 176 patients. While RT‐qPCR was employed to scrutinize hsa_circ_0048122 expression, Kaplan–Meier survival, and multivariate analyses were used to probe its prognostic impact in early‐stage CRC and stage IV CRC cases, respectively.
Results
A strong correlation between liver metastases and hsa_circ_0048122 expression in stage IV CRC patients with a high hsa_circ_0048122 profile indicated a poor overall survival. Likewise, a high expression level of hsa_circ_0048122 appears as a potential predictor of liver metastases in patients' initial stages.
Conclusions
Predicting liver metastasis can be plausibly facilitated using Hsa_circ_0048122 as a biomarker in early‐stage CRC cases.
Figure 1. Profiling of circRNAs from the CRCLM patients. (A) Volcano plot of differentially expressed genes in GEO datasets GSE147597. (B) Mean‐difference plot in GEO datasets GSE147597. (C) Venn diagram analysis of differentially expressed genes. (D) Hsa_circ_0048122 is upregulated in NSCLC compared to adjacent normal tissues.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.24577</identifier><identifier>PMID: 35792043</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>biomarker ; Biomarkers ; Clinical outcomes ; Colorectal cancer ; Colorectal carcinoma ; Datasets ; Gene expression ; hsa_circ_0048122 ; Liver ; Liver cancer ; liver metastasis ; Medical prognosis ; Metastases ; Metastasis ; Patients ; Regression analysis ; Survival ; Survival analysis ; therapy</subject><ispartof>Journal of clinical laboratory analysis, 2022-08, Vol.36 (8), p.e24577-n/a</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC.</rights><rights>2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4257-d7e817e4f649f6afb5063b9aced63c9b15217a94a78cc9fe443d63088ac3388c3</citedby><cites>FETCH-LOGICAL-c4257-d7e817e4f649f6afb5063b9aced63c9b15217a94a78cc9fe443d63088ac3388c3</cites><orcidid>0000-0002-5366-5036</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2705224986/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2705224986?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,11589,25783,27957,27958,37047,37048,44625,46087,46511,53827,53829,75483</link.rule.ids></links><search><creatorcontrib>Fang, Qian</creatorcontrib><creatorcontrib>Ni, Chuandou</creatorcontrib><creatorcontrib>Cai, Zhun</creatorcontrib><creatorcontrib>Li, Wangyong</creatorcontrib><creatorcontrib>Xie, Jianjin</creatorcontrib><title>Prognostic significance of hsa_circ_0048122 to predict liver metastasis in early‐stage colorectal cancer</title><title>Journal of clinical laboratory analysis</title><description>Background
Liver metastasis is the primary cause of lethal colorectal cancer (CRC). The predominant risk of poor patient prognosis in early‐stage CRC emerges as metachronous liver metastasis. This necessitates the search for potential biomarkers for this metastasis to assess treatment outcomes and provide targeted therapy.
Methods
The role of hsa_circ_0048122 in predicting liver metastasis in CRC was probed in this work. This retrospective and multi‐center investigation entailed exploration and identification stages with 158 and 176 patients. While RT‐qPCR was employed to scrutinize hsa_circ_0048122 expression, Kaplan–Meier survival, and multivariate analyses were used to probe its prognostic impact in early‐stage CRC and stage IV CRC cases, respectively.
Results
A strong correlation between liver metastases and hsa_circ_0048122 expression in stage IV CRC patients with a high hsa_circ_0048122 profile indicated a poor overall survival. Likewise, a high expression level of hsa_circ_0048122 appears as a potential predictor of liver metastases in patients' initial stages.
Conclusions
Predicting liver metastasis can be plausibly facilitated using Hsa_circ_0048122 as a biomarker in early‐stage CRC cases.
Figure 1. Profiling of circRNAs from the CRCLM patients. (A) Volcano plot of differentially expressed genes in GEO datasets GSE147597. (B) Mean‐difference plot in GEO datasets GSE147597. (C) Venn diagram analysis of differentially expressed genes. (D) Hsa_circ_0048122 is upregulated in NSCLC compared to adjacent normal tissues.</description><subject>biomarker</subject><subject>Biomarkers</subject><subject>Clinical outcomes</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Datasets</subject><subject>Gene expression</subject><subject>hsa_circ_0048122</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>liver metastasis</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Patients</subject><subject>Regression analysis</subject><subject>Survival</subject><subject>Survival analysis</subject><subject>therapy</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>PIMPY</sourceid><recordid>eNp9kc1qVEEQhRsxmEl04xM0uBHhJv13-2cjhEGNMqALXTc9NXUnPfTcHrvvJMzOR_AZfRI7mSDoQigoqPPVoYpDyEvOLjhj4nIDKVwI1RvzhMw4c7YTVvRPyYxZazrLuDwlZ7VuGGPWcf2MnMreOMGUnJHNl5LXY65TBFrjeoxDhDAC0jzQmxo8xAKeMWW5EHTKdFdwFWGiKd5ioVucQm0VK40jxVDS4dePn22yRgo55YIwhUQfHMtzcjKEVPHFYz8n396_-zq_7hafP3ycXy06UKI33cqg5QbVoJUbdBiWPdNy6QLgSktwS94LboJTwVgAN6BSsgnt1QBSWgvynLw9-u72yy2uAMephOR3JW5DOfgcov9bGeONX-db76TT3Mpm8PrRoOTve6yT38YKmFIYMe-rF9r2ShmhWUNf_YNu8r6M7T0vDOuFUM7qRr05UlByrQWHP8dw5u8j9PcR-ocIG8yP8F1MePgP6T_NF1fHnd8HBJ7u</recordid><startdate>202208</startdate><enddate>202208</enddate><creator>Fang, Qian</creator><creator>Ni, Chuandou</creator><creator>Cai, Zhun</creator><creator>Li, Wangyong</creator><creator>Xie, Jianjin</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5366-5036</orcidid></search><sort><creationdate>202208</creationdate><title>Prognostic significance of hsa_circ_0048122 to predict liver metastasis in early‐stage colorectal cancer</title><author>Fang, Qian ; Ni, Chuandou ; Cai, Zhun ; Li, Wangyong ; Xie, Jianjin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4257-d7e817e4f649f6afb5063b9aced63c9b15217a94a78cc9fe443d63088ac3388c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>biomarker</topic><topic>Biomarkers</topic><topic>Clinical outcomes</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Datasets</topic><topic>Gene expression</topic><topic>hsa_circ_0048122</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>liver metastasis</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Patients</topic><topic>Regression analysis</topic><topic>Survival</topic><topic>Survival analysis</topic><topic>therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fang, Qian</creatorcontrib><creatorcontrib>Ni, Chuandou</creatorcontrib><creatorcontrib>Cai, Zhun</creatorcontrib><creatorcontrib>Li, Wangyong</creatorcontrib><creatorcontrib>Xie, Jianjin</creatorcontrib><collection>Open Access: Wiley-Blackwell Open Access Journals</collection><collection>Wiley Online Library</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fang, Qian</au><au>Ni, Chuandou</au><au>Cai, Zhun</au><au>Li, Wangyong</au><au>Xie, Jianjin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of hsa_circ_0048122 to predict liver metastasis in early‐stage colorectal cancer</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><date>2022-08</date><risdate>2022</risdate><volume>36</volume><issue>8</issue><spage>e24577</spage><epage>n/a</epage><pages>e24577-n/a</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Background
Liver metastasis is the primary cause of lethal colorectal cancer (CRC). The predominant risk of poor patient prognosis in early‐stage CRC emerges as metachronous liver metastasis. This necessitates the search for potential biomarkers for this metastasis to assess treatment outcomes and provide targeted therapy.
Methods
The role of hsa_circ_0048122 in predicting liver metastasis in CRC was probed in this work. This retrospective and multi‐center investigation entailed exploration and identification stages with 158 and 176 patients. While RT‐qPCR was employed to scrutinize hsa_circ_0048122 expression, Kaplan–Meier survival, and multivariate analyses were used to probe its prognostic impact in early‐stage CRC and stage IV CRC cases, respectively.
Results
A strong correlation between liver metastases and hsa_circ_0048122 expression in stage IV CRC patients with a high hsa_circ_0048122 profile indicated a poor overall survival. Likewise, a high expression level of hsa_circ_0048122 appears as a potential predictor of liver metastases in patients' initial stages.
Conclusions
Predicting liver metastasis can be plausibly facilitated using Hsa_circ_0048122 as a biomarker in early‐stage CRC cases.
Figure 1. Profiling of circRNAs from the CRCLM patients. (A) Volcano plot of differentially expressed genes in GEO datasets GSE147597. (B) Mean‐difference plot in GEO datasets GSE147597. (C) Venn diagram analysis of differentially expressed genes. (D) Hsa_circ_0048122 is upregulated in NSCLC compared to adjacent normal tissues.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>35792043</pmid><doi>10.1002/jcla.24577</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5366-5036</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Open Access: Wiley-Blackwell Open Access Journals; Publicly Available Content Database; PubMed Central |
| subjects | biomarker Biomarkers Clinical outcomes Colorectal cancer Colorectal carcinoma Datasets Gene expression hsa_circ_0048122 Liver Liver cancer liver metastasis Medical prognosis Metastases Metastasis Patients Regression analysis Survival Survival analysis therapy |
| title | Prognostic significance of hsa_circ_0048122 to predict liver metastasis in early‐stage colorectal cancer |
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