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From binge eating to binge drinking: A new and robust paradigm for assessing binge ethanol self‐administration in male rats
Animal models of alcohol (ethanol) self‐administration are crucial to dissect the neurobiological mechanisms underlying alcohol dependence, yet only a few of these induce pharmacologically relevant levels of alcohol consumption and rarely the alcohol self‐administration co‐occurs with other addictiv...
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| Published in: | Addiction biology 2022-03, Vol.27 (2), p.e13153-n/a |
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| creator | Ruiz‐Leyva, Leandro Vázquez‐Ágredos, Ana Jiménez‐García, Ana M. López‐Guarnido, Olga Pla, Antonio Pautassi, Ricardo Marcos Morón Henche, Ignacio Cendán, Cruz Miguel |
| description | Animal models of alcohol (ethanol) self‐administration are crucial to dissect the neurobiological mechanisms underlying alcohol dependence, yet only a few of these induce pharmacologically relevant levels of alcohol consumption and rarely the alcohol self‐administration co‐occurs with other addictive behaviours. The present study aims to validate a novel model of voluntary ethanol consumption in male Wistar rats, in which ethanol access follows a binge eating experience. Over 10 sessions, Wistar rats were exposed to binge or control eating (i.e., the ingestion of 11.66 and 0.97 kcal/3 min, respectively, derived from a highly palatable food), immediately followed by two‐bottle choice intake tests (2%, 6%, 10% or 14% w/w ethanol vs. water). Rats exposed to binge eating drank significantly more 6% or 10% (w/w) ethanol than control peers, reaching up to 6.3 gEtOH/kg. Rats stimulated with 2%, 6%, 10% or 14% ethanol after binge eating, but not those given those ethanol concentrations after control eating, exhibited significant within‐group increases in ethanol drinking. This ethanol consumption was not altered by quinine adulteration (up to 0.1 g/L), and it was blocked by naltrexone (10 mg/kg), administered immediately before binge eating. Blood ethanol levels significantly correlated with ethanol consumption; and the more ethanol consumed, the greater the distance travelled in an open field test conducted after the two‐bottle choice test. Altogether, this self‐administration model seems a valid and robust alternative with remarkable potential for research on different stages of the alcohol addiction and, particularly, to assess interactions between alcohol consumption and others addictive‐like behaviours.
This study validated a novel model of voluntary ethanol consumption in male Wistar rats, in which ethanol access follows a binge eating experience. Rats stimulated with 2%, 6%, 10% or 14% ethanol immediately after binge eating, but not those given those ethanol concentrations after control eating, exhibited significant within‐group increases in ethanol drinking. This ethanol consumption was not altered by quinine adulteration (up to 0.1 g/L), and it was blocked by naltrexone (10 mg/kg), administered immediately before binge eating. |
| doi_str_mv | 10.1111/adb.13153 |
| format | article |
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This study validated a novel model of voluntary ethanol consumption in male Wistar rats, in which ethanol access follows a binge eating experience. Rats stimulated with 2%, 6%, 10% or 14% ethanol immediately after binge eating, but not those given those ethanol concentrations after control eating, exhibited significant within‐group increases in ethanol drinking. This ethanol consumption was not altered by quinine adulteration (up to 0.1 g/L), and it was blocked by naltrexone (10 mg/kg), administered immediately before binge eating.</description><identifier>ISSN: 1355-6215</identifier><identifier>EISSN: 1369-1600</identifier><identifier>DOI: 10.1111/adb.13153</identifier><identifier>PMID: 35229947</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Addictions ; Addictive behaviors ; Alcohol ; Alcohol Drinking ; Alcohol use ; Animal models ; Animals ; binge drinking ; Binge Drinking - drug therapy ; Binge eating ; Binge-Eating Disorder ; Drinking behavior ; Drug addiction ; Drug dependence ; Eating disorders ; Ethanol ; Male ; Naltrexone ; Open-field behavior ; Original ; Quinine ; Rats ; Rats, Wistar ; Rodents ; Self Administration</subject><ispartof>Addiction biology, 2022-03, Vol.27 (2), p.e13153-n/a</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.</rights><rights>2022 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4433-ef105fa5cacd0c063896d3372e28718979924925dc341fe70862fb7ea221af73</citedby><cites>FETCH-LOGICAL-c4433-ef105fa5cacd0c063896d3372e28718979924925dc341fe70862fb7ea221af73</cites><orcidid>0000-0001-8865-4903 ; 0000-0001-6229-9122 ; 0000-0002-1387-5602 ; 0000-0001-6400-3436 ; 0000-0002-4953-3161 ; 0000-0003-1876-2321 ; 0000-0001-5431-4513</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fadb.13153$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fadb.13153$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,315,786,790,891,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35229947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruiz‐Leyva, Leandro</creatorcontrib><creatorcontrib>Vázquez‐Ágredos, Ana</creatorcontrib><creatorcontrib>Jiménez‐García, Ana M.</creatorcontrib><creatorcontrib>López‐Guarnido, Olga</creatorcontrib><creatorcontrib>Pla, Antonio</creatorcontrib><creatorcontrib>Pautassi, Ricardo Marcos</creatorcontrib><creatorcontrib>Morón Henche, Ignacio</creatorcontrib><creatorcontrib>Cendán, Cruz Miguel</creatorcontrib><title>From binge eating to binge drinking: A new and robust paradigm for assessing binge ethanol self‐administration in male rats</title><title>Addiction biology</title><addtitle>Addict Biol</addtitle><description>Animal models of alcohol (ethanol) self‐administration are crucial to dissect the neurobiological mechanisms underlying alcohol dependence, yet only a few of these induce pharmacologically relevant levels of alcohol consumption and rarely the alcohol self‐administration co‐occurs with other addictive behaviours. The present study aims to validate a novel model of voluntary ethanol consumption in male Wistar rats, in which ethanol access follows a binge eating experience. Over 10 sessions, Wistar rats were exposed to binge or control eating (i.e., the ingestion of 11.66 and 0.97 kcal/3 min, respectively, derived from a highly palatable food), immediately followed by two‐bottle choice intake tests (2%, 6%, 10% or 14% w/w ethanol vs. water). Rats exposed to binge eating drank significantly more 6% or 10% (w/w) ethanol than control peers, reaching up to 6.3 gEtOH/kg. Rats stimulated with 2%, 6%, 10% or 14% ethanol after binge eating, but not those given those ethanol concentrations after control eating, exhibited significant within‐group increases in ethanol drinking. This ethanol consumption was not altered by quinine adulteration (up to 0.1 g/L), and it was blocked by naltrexone (10 mg/kg), administered immediately before binge eating. Blood ethanol levels significantly correlated with ethanol consumption; and the more ethanol consumed, the greater the distance travelled in an open field test conducted after the two‐bottle choice test. Altogether, this self‐administration model seems a valid and robust alternative with remarkable potential for research on different stages of the alcohol addiction and, particularly, to assess interactions between alcohol consumption and others addictive‐like behaviours.
This study validated a novel model of voluntary ethanol consumption in male Wistar rats, in which ethanol access follows a binge eating experience. Rats stimulated with 2%, 6%, 10% or 14% ethanol immediately after binge eating, but not those given those ethanol concentrations after control eating, exhibited significant within‐group increases in ethanol drinking. This ethanol consumption was not altered by quinine adulteration (up to 0.1 g/L), and it was blocked by naltrexone (10 mg/kg), administered immediately before binge eating.</description><subject>Addictions</subject><subject>Addictive behaviors</subject><subject>Alcohol</subject><subject>Alcohol Drinking</subject><subject>Alcohol use</subject><subject>Animal models</subject><subject>Animals</subject><subject>binge drinking</subject><subject>Binge Drinking - drug therapy</subject><subject>Binge eating</subject><subject>Binge-Eating Disorder</subject><subject>Drinking behavior</subject><subject>Drug addiction</subject><subject>Drug dependence</subject><subject>Eating disorders</subject><subject>Ethanol</subject><subject>Male</subject><subject>Naltrexone</subject><subject>Open-field behavior</subject><subject>Original</subject><subject>Quinine</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Self Administration</subject><issn>1355-6215</issn><issn>1369-1600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1kc9qFTEUh4MotlYXvoAE3Ohi2vyZTCYuhGtta6HgpvuQmZzcps4k12TG0oXgI_iMPomZ3muxgtmcc8iXjxN-CL2k5JCWc2Rsd0g5FfwR2qe8URVtCHm89EJUDaNiDz3L-ZoQyqTgT9EeF4wpVct99P00xRF3PqwBg5lKxVPczTb58KV07_AKB7jBJlicYjfnCW9MMtavR-xiwiZnyHl5uvNMVybEAWcY3K8fP40dffB5SkUfA_YBj2YAXMb8HD1xZsjwYlcP0OXpyeXxp-ri89n58eqi6uua8wocJcIZ0Zvekp40vFWN5VwyYK2krZJKsVoxYXteUweStA1znQTDGDVO8gP0fqvdzN0ItodQlhn0JvnRpFsdjdcPb4K_0uv4TSvWilqpInizE6T4dYY86dHnHobBBIhz1qzhdSuIpAv6-h_0Os4plN_dUVyRWizU2y3Vp5hzAne_DCV6yVSXTPVdpoV99ff29-SfEAtwtAVu_AC3_zfp1ccPW-VvKFStHQ</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Ruiz‐Leyva, Leandro</creator><creator>Vázquez‐Ágredos, Ana</creator><creator>Jiménez‐García, Ana M.</creator><creator>López‐Guarnido, Olga</creator><creator>Pla, Antonio</creator><creator>Pautassi, Ricardo Marcos</creator><creator>Morón Henche, Ignacio</creator><creator>Cendán, Cruz Miguel</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8865-4903</orcidid><orcidid>https://orcid.org/0000-0001-6229-9122</orcidid><orcidid>https://orcid.org/0000-0002-1387-5602</orcidid><orcidid>https://orcid.org/0000-0001-6400-3436</orcidid><orcidid>https://orcid.org/0000-0002-4953-3161</orcidid><orcidid>https://orcid.org/0000-0003-1876-2321</orcidid><orcidid>https://orcid.org/0000-0001-5431-4513</orcidid></search><sort><creationdate>202203</creationdate><title>From binge eating to binge drinking: A new and robust paradigm for assessing binge ethanol self‐administration in male rats</title><author>Ruiz‐Leyva, Leandro ; Vázquez‐Ágredos, Ana ; Jiménez‐García, Ana M. ; López‐Guarnido, Olga ; Pla, Antonio ; Pautassi, Ricardo Marcos ; Morón Henche, Ignacio ; Cendán, Cruz Miguel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4433-ef105fa5cacd0c063896d3372e28718979924925dc341fe70862fb7ea221af73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Addictions</topic><topic>Addictive behaviors</topic><topic>Alcohol</topic><topic>Alcohol Drinking</topic><topic>Alcohol use</topic><topic>Animal models</topic><topic>Animals</topic><topic>binge drinking</topic><topic>Binge Drinking - drug therapy</topic><topic>Binge eating</topic><topic>Binge-Eating Disorder</topic><topic>Drinking behavior</topic><topic>Drug addiction</topic><topic>Drug dependence</topic><topic>Eating disorders</topic><topic>Ethanol</topic><topic>Male</topic><topic>Naltrexone</topic><topic>Open-field behavior</topic><topic>Original</topic><topic>Quinine</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Self Administration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruiz‐Leyva, Leandro</creatorcontrib><creatorcontrib>Vázquez‐Ágredos, Ana</creatorcontrib><creatorcontrib>Jiménez‐García, Ana M.</creatorcontrib><creatorcontrib>López‐Guarnido, Olga</creatorcontrib><creatorcontrib>Pla, Antonio</creatorcontrib><creatorcontrib>Pautassi, Ricardo Marcos</creatorcontrib><creatorcontrib>Morón Henche, Ignacio</creatorcontrib><creatorcontrib>Cendán, Cruz Miguel</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>Wiley-Blackwell Backfiles (Open access)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Addiction biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruiz‐Leyva, Leandro</au><au>Vázquez‐Ágredos, Ana</au><au>Jiménez‐García, Ana M.</au><au>López‐Guarnido, Olga</au><au>Pla, Antonio</au><au>Pautassi, Ricardo Marcos</au><au>Morón Henche, Ignacio</au><au>Cendán, Cruz Miguel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>From binge eating to binge drinking: A new and robust paradigm for assessing binge ethanol self‐administration in male rats</atitle><jtitle>Addiction biology</jtitle><addtitle>Addict Biol</addtitle><date>2022-03</date><risdate>2022</risdate><volume>27</volume><issue>2</issue><spage>e13153</spage><epage>n/a</epage><pages>e13153-n/a</pages><issn>1355-6215</issn><eissn>1369-1600</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Animal models of alcohol (ethanol) self‐administration are crucial to dissect the neurobiological mechanisms underlying alcohol dependence, yet only a few of these induce pharmacologically relevant levels of alcohol consumption and rarely the alcohol self‐administration co‐occurs with other addictive behaviours. The present study aims to validate a novel model of voluntary ethanol consumption in male Wistar rats, in which ethanol access follows a binge eating experience. Over 10 sessions, Wistar rats were exposed to binge or control eating (i.e., the ingestion of 11.66 and 0.97 kcal/3 min, respectively, derived from a highly palatable food), immediately followed by two‐bottle choice intake tests (2%, 6%, 10% or 14% w/w ethanol vs. water). Rats exposed to binge eating drank significantly more 6% or 10% (w/w) ethanol than control peers, reaching up to 6.3 gEtOH/kg. Rats stimulated with 2%, 6%, 10% or 14% ethanol after binge eating, but not those given those ethanol concentrations after control eating, exhibited significant within‐group increases in ethanol drinking. This ethanol consumption was not altered by quinine adulteration (up to 0.1 g/L), and it was blocked by naltrexone (10 mg/kg), administered immediately before binge eating. Blood ethanol levels significantly correlated with ethanol consumption; and the more ethanol consumed, the greater the distance travelled in an open field test conducted after the two‐bottle choice test. Altogether, this self‐administration model seems a valid and robust alternative with remarkable potential for research on different stages of the alcohol addiction and, particularly, to assess interactions between alcohol consumption and others addictive‐like behaviours.
This study validated a novel model of voluntary ethanol consumption in male Wistar rats, in which ethanol access follows a binge eating experience. Rats stimulated with 2%, 6%, 10% or 14% ethanol immediately after binge eating, but not those given those ethanol concentrations after control eating, exhibited significant within‐group increases in ethanol drinking. This ethanol consumption was not altered by quinine adulteration (up to 0.1 g/L), and it was blocked by naltrexone (10 mg/kg), administered immediately before binge eating.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>35229947</pmid><doi>10.1111/adb.13153</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8865-4903</orcidid><orcidid>https://orcid.org/0000-0001-6229-9122</orcidid><orcidid>https://orcid.org/0000-0002-1387-5602</orcidid><orcidid>https://orcid.org/0000-0001-6400-3436</orcidid><orcidid>https://orcid.org/0000-0002-4953-3161</orcidid><orcidid>https://orcid.org/0000-0003-1876-2321</orcidid><orcidid>https://orcid.org/0000-0001-5431-4513</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Addiction biology, 2022-03, Vol.27 (2), p.e13153-n/a |
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| source | Wiley |
| subjects | Addictions Addictive behaviors Alcohol Alcohol Drinking Alcohol use Animal models Animals binge drinking Binge Drinking - drug therapy Binge eating Binge-Eating Disorder Drinking behavior Drug addiction Drug dependence Eating disorders Ethanol Male Naltrexone Open-field behavior Original Quinine Rats Rats, Wistar Rodents Self Administration |
| title | From binge eating to binge drinking: A new and robust paradigm for assessing binge ethanol self‐administration in male rats |
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