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Hair growth promotion effect of cedrol cream and its dermatopharmacokinetics
Topical use of cedrol ethanol has been reported to have a beneficial effect on hair loss. However, the use of cedrol has been limited by application-related issues, such as poor water solubility and volatile features. Therefore, the present study developed a cream formulation of cedrol and evaluated...
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| Published in: | RSC advances 2018-12, Vol.8 (73), p.4217-42178 |
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| creator | Zhang, Yan Wang, Jie-wen Qu, Fan-zhi Zhang, Yu-meng Su, Guang-yue Zhao, Yu-qing |
| description | Topical use of cedrol ethanol has been reported to have a beneficial effect on hair loss. However, the use of cedrol has been limited by application-related issues, such as poor water solubility and volatile features. Therefore, the present study developed a cream formulation of cedrol and evaluated various physicochemical parameters of the prepared cream. The optimized cedrol cream was selected after orthogonal tests and determined further. The dermatopharmacokinetics were studied to investigate the absorption difference between cedrol cream and cedrol ethanol after dermal application, and the concentrations of cedrol in skin were analysed by the gas chromatography-mass spectrometry (GC-MS) method. By comparison, the area under the curve (AUC
0-24 h
) of cedrol cream was almost three times higher than that of cedrol ethanol. Moreover, this study was undertaken to evaluate the hair growth promoting efficacy of cedrol cream in C57BL/6 mice and Wistar rats. Macroscopic assessment and alopecia score showed that C57BL/6 mice treated with cedrol cream showed a faster production of pigmentation and a higher score at different growth stages than other groups. The hair length of the cedrol cream-treated group was much longer than those of the cedrol ethanol and minoxidil groups. Histological analyses indicated that in the cedrol ethanol group, most follicles of the C57BL/6 mice were in the catagen phase, whereas nearly 83% of hair follicles in the cedrol cream group remained in the anagen phase. Taken together, our data strongly suggest that the cream formulation of cedrol has a stronger hair growth promotion effect, gave no irritation and was safe for topical administration.
Topical use of cedrol ethanol has been reported to have a beneficial effect on hair loss. |
| doi_str_mv | 10.1039/c8ra08667b |
| format | article |
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0-24 h
) of cedrol cream was almost three times higher than that of cedrol ethanol. Moreover, this study was undertaken to evaluate the hair growth promoting efficacy of cedrol cream in C57BL/6 mice and Wistar rats. Macroscopic assessment and alopecia score showed that C57BL/6 mice treated with cedrol cream showed a faster production of pigmentation and a higher score at different growth stages than other groups. The hair length of the cedrol cream-treated group was much longer than those of the cedrol ethanol and minoxidil groups. Histological analyses indicated that in the cedrol ethanol group, most follicles of the C57BL/6 mice were in the catagen phase, whereas nearly 83% of hair follicles in the cedrol cream group remained in the anagen phase. Taken together, our data strongly suggest that the cream formulation of cedrol has a stronger hair growth promotion effect, gave no irritation and was safe for topical administration.
Topical use of cedrol ethanol has been reported to have a beneficial effect on hair loss.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/c8ra08667b</identifier><identifier>PMID: 35558774</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Chemistry ; Cream ; Ethanol ; Gas chromatography ; Hair ; Hair loss ; Irritation ; Mass spectrometry ; Mice ; Promotion</subject><ispartof>RSC advances, 2018-12, Vol.8 (73), p.4217-42178</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2018</rights><rights>This journal is © The Royal Society of Chemistry 2018 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-8719b464742d56f3aca9f11f8b4745a2e7ec2a54ca1980d1229ca02f4d0c63403</citedby><cites>FETCH-LOGICAL-c495t-8719b464742d56f3aca9f11f8b4745a2e7ec2a54ca1980d1229ca02f4d0c63403</cites><orcidid>0000-0002-8704-2136</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092075/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092075/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35558774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Wang, Jie-wen</creatorcontrib><creatorcontrib>Qu, Fan-zhi</creatorcontrib><creatorcontrib>Zhang, Yu-meng</creatorcontrib><creatorcontrib>Su, Guang-yue</creatorcontrib><creatorcontrib>Zhao, Yu-qing</creatorcontrib><title>Hair growth promotion effect of cedrol cream and its dermatopharmacokinetics</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>Topical use of cedrol ethanol has been reported to have a beneficial effect on hair loss. However, the use of cedrol has been limited by application-related issues, such as poor water solubility and volatile features. Therefore, the present study developed a cream formulation of cedrol and evaluated various physicochemical parameters of the prepared cream. The optimized cedrol cream was selected after orthogonal tests and determined further. The dermatopharmacokinetics were studied to investigate the absorption difference between cedrol cream and cedrol ethanol after dermal application, and the concentrations of cedrol in skin were analysed by the gas chromatography-mass spectrometry (GC-MS) method. By comparison, the area under the curve (AUC
0-24 h
) of cedrol cream was almost three times higher than that of cedrol ethanol. Moreover, this study was undertaken to evaluate the hair growth promoting efficacy of cedrol cream in C57BL/6 mice and Wistar rats. Macroscopic assessment and alopecia score showed that C57BL/6 mice treated with cedrol cream showed a faster production of pigmentation and a higher score at different growth stages than other groups. The hair length of the cedrol cream-treated group was much longer than those of the cedrol ethanol and minoxidil groups. Histological analyses indicated that in the cedrol ethanol group, most follicles of the C57BL/6 mice were in the catagen phase, whereas nearly 83% of hair follicles in the cedrol cream group remained in the anagen phase. Taken together, our data strongly suggest that the cream formulation of cedrol has a stronger hair growth promotion effect, gave no irritation and was safe for topical administration.
Topical use of cedrol ethanol has been reported to have a beneficial effect on hair loss.</description><subject>Chemistry</subject><subject>Cream</subject><subject>Ethanol</subject><subject>Gas chromatography</subject><subject>Hair</subject><subject>Hair loss</subject><subject>Irritation</subject><subject>Mass spectrometry</subject><subject>Mice</subject><subject>Promotion</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kd9LHDEQx4NUVNQX35WUvohwNskm2eSlYI9WhQOh1Ocwl0286O5mTXIt_e_d69nzx0PnZYaZD9-Z4YvQESXnlFT6s1UJiJKynm-hPUa4nDAi9YdX9S46zPmejCEFZZLuoN1KCKHqmu-h2RWEhO9S_F0WeEixiyXEHjvvnS04emxdk2KLbXLQYegbHErGjUsdlDgsYMw2PoTelWDzAdr20GZ3-Jz30e33bz-nV5PZzeX19GI2sVyLMlE11XMuec1ZI6SvwIL2lHo1H1sCmKudZSC4BaoVaShj2gJhnjfEyoqTah99WesOy3nnGuv6kqA1QwodpD8mQjBvJ31YmLv4y2iiGanFKHD6LJDi49LlYrqQrWtb6F1cZsOk5IooQle7Pr1D7-My9eN7hlGheEWoWAmerSmbYs7J-c0xlJiVT2aqflz89enrCJ-8Pn-D_nNlBD6ugZTtZvpitBkaPzLH_2OqJ7lPoxs</recordid><startdate>20181218</startdate><enddate>20181218</enddate><creator>Zhang, Yan</creator><creator>Wang, Jie-wen</creator><creator>Qu, Fan-zhi</creator><creator>Zhang, Yu-meng</creator><creator>Su, Guang-yue</creator><creator>Zhao, Yu-qing</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8704-2136</orcidid></search><sort><creationdate>20181218</creationdate><title>Hair growth promotion effect of cedrol cream and its dermatopharmacokinetics</title><author>Zhang, Yan ; Wang, Jie-wen ; Qu, Fan-zhi ; Zhang, Yu-meng ; Su, Guang-yue ; Zhao, Yu-qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-8719b464742d56f3aca9f11f8b4745a2e7ec2a54ca1980d1229ca02f4d0c63403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Chemistry</topic><topic>Cream</topic><topic>Ethanol</topic><topic>Gas chromatography</topic><topic>Hair</topic><topic>Hair loss</topic><topic>Irritation</topic><topic>Mass spectrometry</topic><topic>Mice</topic><topic>Promotion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Wang, Jie-wen</creatorcontrib><creatorcontrib>Qu, Fan-zhi</creatorcontrib><creatorcontrib>Zhang, Yu-meng</creatorcontrib><creatorcontrib>Su, Guang-yue</creatorcontrib><creatorcontrib>Zhao, Yu-qing</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yan</au><au>Wang, Jie-wen</au><au>Qu, Fan-zhi</au><au>Zhang, Yu-meng</au><au>Su, Guang-yue</au><au>Zhao, Yu-qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hair growth promotion effect of cedrol cream and its dermatopharmacokinetics</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2018-12-18</date><risdate>2018</risdate><volume>8</volume><issue>73</issue><spage>4217</spage><epage>42178</epage><pages>4217-42178</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Topical use of cedrol ethanol has been reported to have a beneficial effect on hair loss. However, the use of cedrol has been limited by application-related issues, such as poor water solubility and volatile features. Therefore, the present study developed a cream formulation of cedrol and evaluated various physicochemical parameters of the prepared cream. The optimized cedrol cream was selected after orthogonal tests and determined further. The dermatopharmacokinetics were studied to investigate the absorption difference between cedrol cream and cedrol ethanol after dermal application, and the concentrations of cedrol in skin were analysed by the gas chromatography-mass spectrometry (GC-MS) method. By comparison, the area under the curve (AUC
0-24 h
) of cedrol cream was almost three times higher than that of cedrol ethanol. Moreover, this study was undertaken to evaluate the hair growth promoting efficacy of cedrol cream in C57BL/6 mice and Wistar rats. Macroscopic assessment and alopecia score showed that C57BL/6 mice treated with cedrol cream showed a faster production of pigmentation and a higher score at different growth stages than other groups. The hair length of the cedrol cream-treated group was much longer than those of the cedrol ethanol and minoxidil groups. Histological analyses indicated that in the cedrol ethanol group, most follicles of the C57BL/6 mice were in the catagen phase, whereas nearly 83% of hair follicles in the cedrol cream group remained in the anagen phase. Taken together, our data strongly suggest that the cream formulation of cedrol has a stronger hair growth promotion effect, gave no irritation and was safe for topical administration.
Topical use of cedrol ethanol has been reported to have a beneficial effect on hair loss.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35558774</pmid><doi>10.1039/c8ra08667b</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8704-2136</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | PubMed Central |
| subjects | Chemistry Cream Ethanol Gas chromatography Hair Hair loss Irritation Mass spectrometry Mice Promotion |
| title | Hair growth promotion effect of cedrol cream and its dermatopharmacokinetics |
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