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Molecular targets of psychedelic‐induced plasticity
Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the prospect of a psychedelic drug becoming again an approved treatment, much of these efforts have been oriented toward exploring the relationship between the actual psychedelic effects...
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| Published in: | Journal of neurochemistry 2022-07, Vol.162 (1), p.80-88 |
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| container_title | Journal of neurochemistry |
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| creator | Jaster, Alaina M. Fuente Revenga, Mario González‐Maeso, Javier |
| description | Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the prospect of a psychedelic drug becoming again an approved treatment, much of these efforts have been oriented toward exploring the relationship between the actual psychedelic effects and those manifestations of therapeutic interest. Considering the central role of the serotonin 5‐HT2A receptor in the distinct effects of psychedelics in human psyche, neuropharmacology sits at the center of this debate and exploratory continuum. Here we discuss some of the most recent findings in human studies and contextualize them considering previous preclinical models studying phenomena related to synaptic plasticity. A special emphasis is placed on knowledge gaps, challenges, and limitations to evaluate the underpinnings of psychedelics’ potential antidepressant action.
Tryptamine psilocin activates both serotonin 5‐HT1A and 5‐HT2A receptors, contributing to hallucinogenic‐like behavior, but the role of the 5‐HT1A in structural plasticity remains unknown. Phenethylamine DOI is more selective for 5‐HT2 receptors, with higher affinity to 5‐HT2AR, which contributes to both structural plasticity and hallucinogenic‐like behavior. Ergoline LSD activates dopamine D2 receptors as well as 5‐HT1A and 5‐HT2A receptors, which leads to hallucinogenic‐like behavior, but it is unknown how LSD’s polypharmacology influences synaptic structural plasticity. |
| doi_str_mv | 10.1111/jnc.15536 |
| format | article |
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Tryptamine psilocin activates both serotonin 5‐HT1A and 5‐HT2A receptors, contributing to hallucinogenic‐like behavior, but the role of the 5‐HT1A in structural plasticity remains unknown. Phenethylamine DOI is more selective for 5‐HT2 receptors, with higher affinity to 5‐HT2AR, which contributes to both structural plasticity and hallucinogenic‐like behavior. Ergoline LSD activates dopamine D2 receptors as well as 5‐HT1A and 5‐HT2A receptors, which leads to hallucinogenic‐like behavior, but it is unknown how LSD’s polypharmacology influences synaptic structural plasticity.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/jnc.15536</identifier><identifier>PMID: 34741320</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>5‐HT2A receptor ; Antidepressants ; GPCR ; hallucinogens ; LSD ; Plasticity ; Psychedelic drugs ; psychedelics ; Serotonin ; Synaptic plasticity</subject><ispartof>Journal of neurochemistry, 2022-07, Vol.162 (1), p.80-88</ispartof><rights>2021 International Society for Neurochemistry</rights><rights>2021 International Society for Neurochemistry.</rights><rights>Copyright © 2022 International Society for Neurochemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4436-cb0f11d6d25e0654171095c255c9873ed20ac5a077ac3ed4d175646074bd6f9a3</citedby><cites>FETCH-LOGICAL-c4436-cb0f11d6d25e0654171095c255c9873ed20ac5a077ac3ed4d175646074bd6f9a3</cites><orcidid>0000-0003-3105-3204</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjnc.15536$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjnc.15536$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,786,790,891,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34741320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jaster, Alaina M.</creatorcontrib><creatorcontrib>Fuente Revenga, Mario</creatorcontrib><creatorcontrib>González‐Maeso, Javier</creatorcontrib><title>Molecular targets of psychedelic‐induced plasticity</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the prospect of a psychedelic drug becoming again an approved treatment, much of these efforts have been oriented toward exploring the relationship between the actual psychedelic effects and those manifestations of therapeutic interest. Considering the central role of the serotonin 5‐HT2A receptor in the distinct effects of psychedelics in human psyche, neuropharmacology sits at the center of this debate and exploratory continuum. Here we discuss some of the most recent findings in human studies and contextualize them considering previous preclinical models studying phenomena related to synaptic plasticity. A special emphasis is placed on knowledge gaps, challenges, and limitations to evaluate the underpinnings of psychedelics’ potential antidepressant action.
Tryptamine psilocin activates both serotonin 5‐HT1A and 5‐HT2A receptors, contributing to hallucinogenic‐like behavior, but the role of the 5‐HT1A in structural plasticity remains unknown. Phenethylamine DOI is more selective for 5‐HT2 receptors, with higher affinity to 5‐HT2AR, which contributes to both structural plasticity and hallucinogenic‐like behavior. Ergoline LSD activates dopamine D2 receptors as well as 5‐HT1A and 5‐HT2A receptors, which leads to hallucinogenic‐like behavior, but it is unknown how LSD’s polypharmacology influences synaptic structural plasticity.</description><subject>5‐HT2A receptor</subject><subject>Antidepressants</subject><subject>GPCR</subject><subject>hallucinogens</subject><subject>LSD</subject><subject>Plasticity</subject><subject>Psychedelic drugs</subject><subject>psychedelics</subject><subject>Serotonin</subject><subject>Synaptic plasticity</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kLtOwzAUhi0EoqUw8AIoEhNDWt-dLEio4qoCC8yWazttqpAEOwFl4xF4Rp4EQ0oFA16OrPPpO79-AA4RHKPwJqtSjxFjhG-BIaICxRSxdBsMIcQ4JpDiAdjzfgUh4pSjXTAgVFBEMBwCdlsVVreFclGj3MI2PqqyqPadXlpji1x_vL3npWm1NVFdKN_kOm-6fbCTqcLbg_UcgceL84fpVTy7v7yens1iTSnhsZ7DDCHDDWYWckaRQDBlGjOm00QQazBUmikohNLhRw0SLCSEgs4Nz1JFRuC099bt_MkabcvGqULWLn9SrpOVyuXfTZkv5aJ6kSnkSUJQEByvBa56bq1v5KpqXRkyS8wTzBKBkzRQJz2lXeW9s9nmAoLyq2EZGpbfDQf26HekDflTaQAmPfCaF7b73yRv7qa98hPj_YYX</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Jaster, Alaina M.</creator><creator>Fuente Revenga, Mario</creator><creator>González‐Maeso, Javier</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3105-3204</orcidid></search><sort><creationdate>202207</creationdate><title>Molecular targets of psychedelic‐induced plasticity</title><author>Jaster, Alaina M. ; Fuente Revenga, Mario ; González‐Maeso, Javier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4436-cb0f11d6d25e0654171095c255c9873ed20ac5a077ac3ed4d175646074bd6f9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>5‐HT2A receptor</topic><topic>Antidepressants</topic><topic>GPCR</topic><topic>hallucinogens</topic><topic>LSD</topic><topic>Plasticity</topic><topic>Psychedelic drugs</topic><topic>psychedelics</topic><topic>Serotonin</topic><topic>Synaptic plasticity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jaster, Alaina M.</creatorcontrib><creatorcontrib>Fuente Revenga, Mario</creatorcontrib><creatorcontrib>González‐Maeso, Javier</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jaster, Alaina M.</au><au>Fuente Revenga, Mario</au><au>González‐Maeso, Javier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular targets of psychedelic‐induced plasticity</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>2022-07</date><risdate>2022</risdate><volume>162</volume><issue>1</issue><spage>80</spage><epage>88</epage><pages>80-88</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><notes>Psychedelics and Neurochemistry</notes><notes>This Review is part of the special issue</notes><notes>.</notes><notes>A.M.J., M.d.l.F.R., and J.G.-M. reviewed the literature and wrote the manuscript.</notes><notes>AUTHORS’ CONTRIBUTIONS</notes><abstract>Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the prospect of a psychedelic drug becoming again an approved treatment, much of these efforts have been oriented toward exploring the relationship between the actual psychedelic effects and those manifestations of therapeutic interest. Considering the central role of the serotonin 5‐HT2A receptor in the distinct effects of psychedelics in human psyche, neuropharmacology sits at the center of this debate and exploratory continuum. Here we discuss some of the most recent findings in human studies and contextualize them considering previous preclinical models studying phenomena related to synaptic plasticity. A special emphasis is placed on knowledge gaps, challenges, and limitations to evaluate the underpinnings of psychedelics’ potential antidepressant action.
Tryptamine psilocin activates both serotonin 5‐HT1A and 5‐HT2A receptors, contributing to hallucinogenic‐like behavior, but the role of the 5‐HT1A in structural plasticity remains unknown. Phenethylamine DOI is more selective for 5‐HT2 receptors, with higher affinity to 5‐HT2AR, which contributes to both structural plasticity and hallucinogenic‐like behavior. Ergoline LSD activates dopamine D2 receptors as well as 5‐HT1A and 5‐HT2A receptors, which leads to hallucinogenic‐like behavior, but it is unknown how LSD’s polypharmacology influences synaptic structural plasticity.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>34741320</pmid><doi>10.1111/jnc.15536</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3105-3204</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3042 |
| ispartof | Journal of neurochemistry, 2022-07, Vol.162 (1), p.80-88 |
| issn | 0022-3042 1471-4159 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9068831 |
| source | Wiley; Full-Text Journals in Chemistry (Open access) |
| subjects | 5‐HT2A receptor Antidepressants GPCR hallucinogens LSD Plasticity Psychedelic drugs psychedelics Serotonin Synaptic plasticity |
| title | Molecular targets of psychedelic‐induced plasticity |
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