Loading…
Different Course of SARS-CoV-2 Infection in Two Adolescents With Other Immunosuppressive Factors
Even after two years of the Coronavirus Disease 2019 (COVID-19) pandemic, despite known risk factors, we are still unable to predict the severity of the infection in specific patients. Due to the contradictory data, the protective role of immunosuppression in preventing the severe course of the infe...
Saved in:
| Published in: | Curēus (Palo Alto, CA) CA), 2022-02, Vol.14 (2), p.e22710 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c309t-34532538ed99166c0274d7fa6b99540de817c008dba6c76cba3a49d479624fc83 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c309t-34532538ed99166c0274d7fa6b99540de817c008dba6c76cba3a49d479624fc83 |
| container_end_page | |
| container_issue | 2 |
| container_start_page | e22710 |
| container_title | Curēus (Palo Alto, CA) |
| container_volume | 14 |
| creator | Kuczborska, Karolina Buda, Piotr Książyk, Janusz B |
| description | Even after two years of the Coronavirus Disease 2019 (COVID-19) pandemic, despite known risk factors, we are still unable to predict the severity of the infection in specific patients. Due to the contradictory data, the protective role of immunosuppression in preventing the severe course of the infection remains uncertain. Therefore, we want to discuss the influence of several immunosuppressive factors on the COVID-19 pattern in children, based on two case reports regarding 17-year-old boys with other immunosuppressive factors and a completely different course of the disease. The first patient suffered from AIDS, syphilis and primary central nervous system B-cell lymphoma, treated with radiotherapy. He experienced a light path of the infection, presenting only periodically appearing cough with no X-ray inflammatory changes. Nevertheless, due to the risk of severe COVID-19 and transient hypoxia, remdesivir was administered. He remained in a generally good condition and his follow-up did not reveal any noticeable complications. The second patient was characterised by Down syndrome, obesity, polyarteritis nodosa and chronic immunosuppressive therapy. He developed massive pneumonia, required treatment in the intensive care unit with the use of mechanical ventilation, remdesivir and anakinra. Despite the initial improvement of his general condition, including the degree of lung involvement and respiratory function, he developed an intracerebral haemorrhage, leading to brain herniation and ultimately death. In conclusion, HIV infection, oncological and immunosuppressive treatment do not seem to predispose to the severe course of COVID-19, whereas Down syndrome and obesity do. |
| doi_str_mv | 10.7759/cureus.22710 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8967115</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2657631488</sourcerecordid><originalsourceid>FETCH-LOGICAL-c309t-34532538ed99166c0274d7fa6b99540de817c008dba6c76cba3a49d479624fc83</originalsourceid><addsrcrecordid>eNpVkc1PwkAQxTdGIwS5eTabeLW4H-1-XEwIipKQkAjqcV22WymBbt1tMf73FkGCp5lk3rx5mR8Alxj1OE_kram9rUOPEI7RCWgTzEQksIhPj_oW6IawRAhhxAni6By0aEIFw5y3wft9nmXW26KCA1f7YKHL4LT_PI0G7jUicFRk1lS5K2BewNmXg_3UrWwwzUKAb3m1gJNqYT0crdd14UJdlt6GkG8sHGpTOR8uwFmmV8F297UDXoYPs8FTNJ48jgb9cWQoklVE44SSJpVNpcSMGUR4nPJMs7mUSYxSKzA3CIl0rpnhzMw11bFMYy4ZiTMjaAfc7XzLer626Tag1ytV-nyt_bdyOlf_J0W-UB9uo4RkHOOkMbjeG3j3WdtQqWXzkKLJrAhLOKM4FtszNzuV8S4Eb7PDBYzUFonaIVG_SBr51XGqg_gPAP0B6PWItw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2657631488</pqid></control><display><type>article</type><title>Different Course of SARS-CoV-2 Infection in Two Adolescents With Other Immunosuppressive Factors</title><source>PubMed Central</source><source>Coronavirus Research Database</source><creator>Kuczborska, Karolina ; Buda, Piotr ; Książyk, Janusz B</creator><creatorcontrib>Kuczborska, Karolina ; Buda, Piotr ; Książyk, Janusz B</creatorcontrib><description>Even after two years of the Coronavirus Disease 2019 (COVID-19) pandemic, despite known risk factors, we are still unable to predict the severity of the infection in specific patients. Due to the contradictory data, the protective role of immunosuppression in preventing the severe course of the infection remains uncertain. Therefore, we want to discuss the influence of several immunosuppressive factors on the COVID-19 pattern in children, based on two case reports regarding 17-year-old boys with other immunosuppressive factors and a completely different course of the disease. The first patient suffered from AIDS, syphilis and primary central nervous system B-cell lymphoma, treated with radiotherapy. He experienced a light path of the infection, presenting only periodically appearing cough with no X-ray inflammatory changes. Nevertheless, due to the risk of severe COVID-19 and transient hypoxia, remdesivir was administered. He remained in a generally good condition and his follow-up did not reveal any noticeable complications. The second patient was characterised by Down syndrome, obesity, polyarteritis nodosa and chronic immunosuppressive therapy. He developed massive pneumonia, required treatment in the intensive care unit with the use of mechanical ventilation, remdesivir and anakinra. Despite the initial improvement of his general condition, including the degree of lung involvement and respiratory function, he developed an intracerebral haemorrhage, leading to brain herniation and ultimately death. In conclusion, HIV infection, oncological and immunosuppressive treatment do not seem to predispose to the severe course of COVID-19, whereas Down syndrome and obesity do.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.22710</identifier><identifier>PMID: 35386177</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Allergy/Immunology ; Antiviral drugs ; Case reports ; Chemotherapy ; Chronic illnesses ; Coronaviruses ; COVID-19 vaccines ; Down syndrome ; Dyspnea ; Fever ; HIV ; Hospitalization ; Human immunodeficiency virus ; Infections ; Infectious Disease ; Leukopenia ; Lymphoma ; Mortality ; Oxygen saturation ; Oxygen therapy ; Pandemics ; Patients ; Pediatrics ; Pneumonia ; Radiation therapy ; Severe acute respiratory syndrome coronavirus 2 ; Syphilis ; Teenagers ; Tomography ; Ventilators</subject><ispartof>Curēus (Palo Alto, CA), 2022-02, Vol.14 (2), p.e22710</ispartof><rights>Copyright © 2022, Kuczborska et al.</rights><rights>Copyright © 2022, Kuczborska et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022, Kuczborska et al. 2022 Kuczborska et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-34532538ed99166c0274d7fa6b99540de817c008dba6c76cba3a49d479624fc83</citedby><cites>FETCH-LOGICAL-c309t-34532538ed99166c0274d7fa6b99540de817c008dba6c76cba3a49d479624fc83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2657631488/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2657631488?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,38551,43930,53827,53829,74769</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35386177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuczborska, Karolina</creatorcontrib><creatorcontrib>Buda, Piotr</creatorcontrib><creatorcontrib>Książyk, Janusz B</creatorcontrib><title>Different Course of SARS-CoV-2 Infection in Two Adolescents With Other Immunosuppressive Factors</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Even after two years of the Coronavirus Disease 2019 (COVID-19) pandemic, despite known risk factors, we are still unable to predict the severity of the infection in specific patients. Due to the contradictory data, the protective role of immunosuppression in preventing the severe course of the infection remains uncertain. Therefore, we want to discuss the influence of several immunosuppressive factors on the COVID-19 pattern in children, based on two case reports regarding 17-year-old boys with other immunosuppressive factors and a completely different course of the disease. The first patient suffered from AIDS, syphilis and primary central nervous system B-cell lymphoma, treated with radiotherapy. He experienced a light path of the infection, presenting only periodically appearing cough with no X-ray inflammatory changes. Nevertheless, due to the risk of severe COVID-19 and transient hypoxia, remdesivir was administered. He remained in a generally good condition and his follow-up did not reveal any noticeable complications. The second patient was characterised by Down syndrome, obesity, polyarteritis nodosa and chronic immunosuppressive therapy. He developed massive pneumonia, required treatment in the intensive care unit with the use of mechanical ventilation, remdesivir and anakinra. Despite the initial improvement of his general condition, including the degree of lung involvement and respiratory function, he developed an intracerebral haemorrhage, leading to brain herniation and ultimately death. In conclusion, HIV infection, oncological and immunosuppressive treatment do not seem to predispose to the severe course of COVID-19, whereas Down syndrome and obesity do.</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>Allergy/Immunology</subject><subject>Antiviral drugs</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Chronic illnesses</subject><subject>Coronaviruses</subject><subject>COVID-19 vaccines</subject><subject>Down syndrome</subject><subject>Dyspnea</subject><subject>Fever</subject><subject>HIV</subject><subject>Hospitalization</subject><subject>Human immunodeficiency virus</subject><subject>Infections</subject><subject>Infectious Disease</subject><subject>Leukopenia</subject><subject>Lymphoma</subject><subject>Mortality</subject><subject>Oxygen saturation</subject><subject>Oxygen therapy</subject><subject>Pandemics</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Pneumonia</subject><subject>Radiation therapy</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Syphilis</subject><subject>Teenagers</subject><subject>Tomography</subject><subject>Ventilators</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><sourceid>PIMPY</sourceid><recordid>eNpVkc1PwkAQxTdGIwS5eTabeLW4H-1-XEwIipKQkAjqcV22WymBbt1tMf73FkGCp5lk3rx5mR8Alxj1OE_kram9rUOPEI7RCWgTzEQksIhPj_oW6IawRAhhxAni6By0aEIFw5y3wft9nmXW26KCA1f7YKHL4LT_PI0G7jUicFRk1lS5K2BewNmXg_3UrWwwzUKAb3m1gJNqYT0crdd14UJdlt6GkG8sHGpTOR8uwFmmV8F297UDXoYPs8FTNJ48jgb9cWQoklVE44SSJpVNpcSMGUR4nPJMs7mUSYxSKzA3CIl0rpnhzMw11bFMYy4ZiTMjaAfc7XzLer626Tag1ytV-nyt_bdyOlf_J0W-UB9uo4RkHOOkMbjeG3j3WdtQqWXzkKLJrAhLOKM4FtszNzuV8S4Eb7PDBYzUFonaIVG_SBr51XGqg_gPAP0B6PWItw</recordid><startdate>20220228</startdate><enddate>20220228</enddate><creator>Kuczborska, Karolina</creator><creator>Buda, Piotr</creator><creator>Książyk, Janusz B</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20220228</creationdate><title>Different Course of SARS-CoV-2 Infection in Two Adolescents With Other Immunosuppressive Factors</title><author>Kuczborska, Karolina ; Buda, Piotr ; Książyk, Janusz B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-34532538ed99166c0274d7fa6b99540de817c008dba6c76cba3a49d479624fc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>AIDS</topic><topic>Allergy/Immunology</topic><topic>Antiviral drugs</topic><topic>Case reports</topic><topic>Chemotherapy</topic><topic>Chronic illnesses</topic><topic>Coronaviruses</topic><topic>COVID-19 vaccines</topic><topic>Down syndrome</topic><topic>Dyspnea</topic><topic>Fever</topic><topic>HIV</topic><topic>Hospitalization</topic><topic>Human immunodeficiency virus</topic><topic>Infections</topic><topic>Infectious Disease</topic><topic>Leukopenia</topic><topic>Lymphoma</topic><topic>Mortality</topic><topic>Oxygen saturation</topic><topic>Oxygen therapy</topic><topic>Pandemics</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Pneumonia</topic><topic>Radiation therapy</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Syphilis</topic><topic>Teenagers</topic><topic>Tomography</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuczborska, Karolina</creatorcontrib><creatorcontrib>Buda, Piotr</creatorcontrib><creatorcontrib>Książyk, Janusz B</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuczborska, Karolina</au><au>Buda, Piotr</au><au>Książyk, Janusz B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different Course of SARS-CoV-2 Infection in Two Adolescents With Other Immunosuppressive Factors</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2022-02-28</date><risdate>2022</risdate><volume>14</volume><issue>2</issue><spage>e22710</spage><pages>e22710-</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Even after two years of the Coronavirus Disease 2019 (COVID-19) pandemic, despite known risk factors, we are still unable to predict the severity of the infection in specific patients. Due to the contradictory data, the protective role of immunosuppression in preventing the severe course of the infection remains uncertain. Therefore, we want to discuss the influence of several immunosuppressive factors on the COVID-19 pattern in children, based on two case reports regarding 17-year-old boys with other immunosuppressive factors and a completely different course of the disease. The first patient suffered from AIDS, syphilis and primary central nervous system B-cell lymphoma, treated with radiotherapy. He experienced a light path of the infection, presenting only periodically appearing cough with no X-ray inflammatory changes. Nevertheless, due to the risk of severe COVID-19 and transient hypoxia, remdesivir was administered. He remained in a generally good condition and his follow-up did not reveal any noticeable complications. The second patient was characterised by Down syndrome, obesity, polyarteritis nodosa and chronic immunosuppressive therapy. He developed massive pneumonia, required treatment in the intensive care unit with the use of mechanical ventilation, remdesivir and anakinra. Despite the initial improvement of his general condition, including the degree of lung involvement and respiratory function, he developed an intracerebral haemorrhage, leading to brain herniation and ultimately death. In conclusion, HIV infection, oncological and immunosuppressive treatment do not seem to predispose to the severe course of COVID-19, whereas Down syndrome and obesity do.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>35386177</pmid><doi>10.7759/cureus.22710</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2168-8184 |
| ispartof | Curēus (Palo Alto, CA), 2022-02, Vol.14 (2), p.e22710 |
| issn | 2168-8184 2168-8184 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8967115 |
| source | PubMed Central; Coronavirus Research Database |
| subjects | Acquired immune deficiency syndrome AIDS Allergy/Immunology Antiviral drugs Case reports Chemotherapy Chronic illnesses Coronaviruses COVID-19 vaccines Down syndrome Dyspnea Fever HIV Hospitalization Human immunodeficiency virus Infections Infectious Disease Leukopenia Lymphoma Mortality Oxygen saturation Oxygen therapy Pandemics Patients Pediatrics Pneumonia Radiation therapy Severe acute respiratory syndrome coronavirus 2 Syphilis Teenagers Tomography Ventilators |
| title | Different Course of SARS-CoV-2 Infection in Two Adolescents With Other Immunosuppressive Factors |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T12%3A42%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Different%20Course%20of%20SARS-CoV-2%20Infection%20in%20Two%20Adolescents%20With%20Other%20Immunosuppressive%20Factors&rft.jtitle=Cur%C4%93us%20(Palo%20Alto,%20CA)&rft.au=Kuczborska,%20Karolina&rft.date=2022-02-28&rft.volume=14&rft.issue=2&rft.spage=e22710&rft.pages=e22710-&rft.issn=2168-8184&rft.eissn=2168-8184&rft_id=info:doi/10.7759/cureus.22710&rft_dat=%3Cproquest_pubme%3E2657631488%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c309t-34532538ed99166c0274d7fa6b99540de817c008dba6c76cba3a49d479624fc83%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2657631488&rft_id=info:pmid/35386177&rfr_iscdi=true |