Characteristics of Intracranial Group A Streptococcal Infections in US Children, 1997-2014

Few data on intracranial group A Streptococcus (GAS) infection in children are available. Here, we describe the demographic, clinical, and diagnostic characteristics of 91 children with intracranial GAS infection. Cases of intracranial GAS infection in persons ≤18 years of age reported between 1997...

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Bibliographic Details
Published in:Journal of the Pediatric Infectious Diseases Society 2020-02, Vol.9 (1), p.30-35
Main Authors: Link-Gelles, Ruth, Toews, Karrie-Ann, Schaffner, William, Edwards, Kathryn M, Wright, Carolyn, Beall, Bernard, Barnes, Brenda, Jewell, Brenda, Harrison, Lee H, Kirley, Pam D, Lorentzson, Lauren, Aragon, Deborah, Petit, Susan, Bareta, Joseph, Spina, Nancy L, Cieslak, Paul R, Van Beneden, Chris
Format: Article
Language:English
Subjects:
Adolescent
Age Distribution
Brain Diseases - epidemiology
Brain Diseases - microbiology
Brain Diseases - mortality
Central Nervous System Bacterial Infections - epidemiology
Central Nervous System Bacterial Infections - microbiology
Central Nervous System Bacterial Infections - mortality
Child
Child, Preschool
Female
Humans
Incidence
Infant
Male
Mastoiditis - complications
Mastoiditis - microbiology
Meningitis, Bacterial - epidemiology
Meningitis, Bacterial - mortality
Otitis Media - complications
Otitis Media - microbiology
Risk Factors
Shock, Septic - etiology
Sinusitis - complications
Sinusitis - microbiology
Streptococcal Infections - complications
Streptococcal Infections - epidemiology
Streptococcal Infections - mortality
Streptococcus pyogenes - isolation & purification
United States - epidemiology
Ventriculoperitoneal Shunt
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Summary:Few data on intracranial group A Streptococcus (GAS) infection in children are available. Here, we describe the demographic, clinical, and diagnostic characteristics of 91 children with intracranial GAS infection. Cases of intracranial GAS infection in persons ≤18 years of age reported between 1997 and 2014 were identified by the Centers for Disease Control and Prevention's population- and laboratory-based Active Bacterial Core surveillance (ABCs) system. Medical charts were abstracted using a active, standardized case report form. All available isolates were emm typed. US census data were used to calculate rates. ABCs identified 2596 children with invasive GAS infection over an 18-year period; 91 (3.5%) had an intracranial infection. Intracranial infections were most frequent during the winter months and among children aged
ISSN:2048-7193
2048-7207
DOI:10.1093/jpids/piy108