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Vagal sensory neurons drive mucous cell metaplasia
Airway sensory neuron-produced Substance P heightens allergy-induced goblet cell hyperplasia and hypersecretion of Muc5AC, electrically silencing these overreactive neurons reduced these components of lung type 2 allergic inflammatory response.
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| Published in: | Journal of allergy and clinical immunology 2020-06, Vol.145 (6), p.1693-1696.e4 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c455t-9188d59aab705054ce6feeb8b502b570524187b09443c33facd014237ba5feeb3 |
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| cites | cdi_FETCH-LOGICAL-c455t-9188d59aab705054ce6feeb8b502b570524187b09443c33facd014237ba5feeb3 |
| container_end_page | 1696.e4 |
| container_issue | 6 |
| container_start_page | 1693 |
| container_title | Journal of allergy and clinical immunology |
| container_volume | 145 |
| creator | Talbot, Sébastien Doyle, Benjamin Huang, Junwei Wang, Jo-Chiao Ahmadi, Maryam Roberson, David P. Yekkirala, Ajay Foster, Simmie L. Browne, Liam E. Bean, Bruce P. Levy, Bruce D. Woolf, Clifford J. |
| description | Airway sensory neuron-produced Substance P heightens allergy-induced goblet cell hyperplasia and hypersecretion of Muc5AC, electrically silencing these overreactive neurons reduced these components of lung type 2 allergic inflammatory response. |
| doi_str_mv | 10.1016/j.jaci.2020.01.003 |
| format | article |
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| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 2020-06, Vol.145 (6), p.1693-1696.e4 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8603302 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Animals Female Immunity, Innate - physiology Inflammation - pathology Lung - pathology Male Metaplasia - pathology Metaplasia - physiopathology Mice Mice, Inbred C57BL Mucus - physiology Sensory Receptor Cells - physiology Vagus Nerve - physiology |
| title | Vagal sensory neurons drive mucous cell metaplasia |
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