Loading…
CD36 – A novel molecular target in the neurovascular unit
CD36 is an integral membrane protein primarily known for its function as a fatty acid transporter, yet also playing other biological roles from lipid metabolism to inflammation modulation. These pleiotropic effects are explained by the existence of multiple different ligands and the extensive distri...
Saved in:
| Published in: | The European journal of neuroscience 2021-04, Vol.53 (8), p.2500-2510 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4437-82373b7a938393e48284ccb551f3a57c1395130385e7766b3ef0face83d68483 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4437-82373b7a938393e48284ccb551f3a57c1395130385e7766b3ef0face83d68483 |
| container_end_page | 2510 |
| container_issue | 8 |
| container_start_page | 2500 |
| container_title | The European journal of neuroscience |
| container_volume | 53 |
| creator | Ioghen, Octavian Chițoiu, Leona Gherghiceanu, Mihaela Ceafalan, Laura Cristina Hinescu, Mihail Eugen Majewska, Ania |
| description | CD36 is an integral membrane protein primarily known for its function as a fatty acid transporter, yet also playing other biological roles from lipid metabolism to inflammation modulation. These pleiotropic effects are explained by the existence of multiple different ligands and the extensive distribution in numerous cell types. Moreover, the receptor is related to various pathologies and it may prove to be a good target for prospective therapeutic strategies. In the neurovascular unit (NVU), CD36 is expressed in cells like microglia, microvascular endothelial cells, astrocytes and neurons. In the normal brain, CD36 was proven to be involved in phagocytosis of apoptotic cells, oro‐sensory detection of dietary lipids, and fatty acid transport across the blood brain barrier (BBB). CD36 was also acknowledged as a potentially important player in central nervous system (CNS) disorders, such as Alzheimer Disease‐associated vascular dysfunction and oxidative stress and the neuroinflammatory response in stroke. Despite continuous efforts, the therapeutic arsenal for such diseases is still scarce and there is an increasing interest in discovering new molecular targets for more specific therapeutic approaches. In this review, we summarize the role of CD36 in the normal function of the NVU and in several CNS disorders, focusing on the dysregulation of the NVU and the potential therapeutic modulation.
CD36 is an integral membrane protein primarily known as a fatty acids transporter, yet also involved in lipid metabolism and inflammation. These pleiotropic effects are explained by its multiple ligands and its extensive distribution on numerous cell types. As CD36 participates both to the normal function and dysregulation of the neurovascular unit in several central nervous system disorders, it might prove to be a good target for prospective therapeutic strategies. |
| doi_str_mv | 10.1111/ejn.15147 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8247892</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2487744762</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4437-82373b7a938393e48284ccb551f3a57c1395130385e7766b3ef0face83d68483</originalsourceid><addsrcrecordid>eNp1kctKHEEUhouQkJmoC18gNGRjFq1VferWBAQZLzGIbmbhrqgpTzs99FSZqu4Rd76Db-iT2No6aCBncxbn4-M__IRsM7rL-tnDhd9lgnH1iYwZlzQvhdSfyZiWAnLN5OWIfEtpQSnVkouvZAQgJBWSjcmvySHI7PH-ITvIfFhhky1Dg65rbMxaG6-xzWqftXPMPHYxrGwabp2v203ypbJNwq3XvUGmx0fTye_87OLkdHJwljvOQeW6AAUzZUvQUAJyXWju3EwIVoEVyjEoBQMKWqBSUs4AK1pZhxqupOYaNsj-oL3pZku8cujbaBtzE-uljXcm2Np8vPh6bq7DyuiCK10WvWDnVRDD3w5Ta5Z1ctg01mPokim4VopzJZ_RH_-gi9BF339nCsG0VIxS1VM_B8rFkFLEah2GUfPciOkbMS-N9Oz39-nX5FsFPbA3ALd1g3f_N5mjP-eD8gnMBZPa</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2518671007</pqid></control><display><type>article</type><title>CD36 – A novel molecular target in the neurovascular unit</title><source>Wiley-Blackwell Journals</source><creator>Ioghen, Octavian ; Chițoiu, Leona ; Gherghiceanu, Mihaela ; Ceafalan, Laura Cristina ; Hinescu, Mihail Eugen ; Majewska, Ania</creator><contributor>Majewska, Ania</contributor><creatorcontrib>Ioghen, Octavian ; Chițoiu, Leona ; Gherghiceanu, Mihaela ; Ceafalan, Laura Cristina ; Hinescu, Mihail Eugen ; Majewska, Ania ; Majewska, Ania</creatorcontrib><description>CD36 is an integral membrane protein primarily known for its function as a fatty acid transporter, yet also playing other biological roles from lipid metabolism to inflammation modulation. These pleiotropic effects are explained by the existence of multiple different ligands and the extensive distribution in numerous cell types. Moreover, the receptor is related to various pathologies and it may prove to be a good target for prospective therapeutic strategies. In the neurovascular unit (NVU), CD36 is expressed in cells like microglia, microvascular endothelial cells, astrocytes and neurons. In the normal brain, CD36 was proven to be involved in phagocytosis of apoptotic cells, oro‐sensory detection of dietary lipids, and fatty acid transport across the blood brain barrier (BBB). CD36 was also acknowledged as a potentially important player in central nervous system (CNS) disorders, such as Alzheimer Disease‐associated vascular dysfunction and oxidative stress and the neuroinflammatory response in stroke. Despite continuous efforts, the therapeutic arsenal for such diseases is still scarce and there is an increasing interest in discovering new molecular targets for more specific therapeutic approaches. In this review, we summarize the role of CD36 in the normal function of the NVU and in several CNS disorders, focusing on the dysregulation of the NVU and the potential therapeutic modulation.
CD36 is an integral membrane protein primarily known as a fatty acids transporter, yet also involved in lipid metabolism and inflammation. These pleiotropic effects are explained by its multiple ligands and its extensive distribution on numerous cell types. As CD36 participates both to the normal function and dysregulation of the neurovascular unit in several central nervous system disorders, it might prove to be a good target for prospective therapeutic strategies.</description><identifier>ISSN: 0953-816X</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/ejn.15147</identifier><identifier>PMID: 33560561</identifier><language>eng</language><publisher>France: Wiley Subscription Services, Inc</publisher><subject>Alzheimer Disease ; Alzheimer's disease ; Apoptosis ; Astrocytes ; Blood-brain barrier ; CD36 ; CD36 antigen ; Central nervous system ; Endothelial cells ; Fatty acids ; Inflammation ; Lipid metabolism ; Membrane proteins ; Microglia ; Microvasculature ; Molecular and Synaptic Mechanisms ; Neurodegenerative diseases ; neuroinflammation ; neurovascular unit ; Oxidative stress ; Phagocytosis ; Review ; stroke ; vascular dysfunction</subject><ispartof>The European journal of neuroscience, 2021-04, Vol.53 (8), p.2500-2510</ispartof><rights>2021 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4437-82373b7a938393e48284ccb551f3a57c1395130385e7766b3ef0face83d68483</citedby><cites>FETCH-LOGICAL-c4437-82373b7a938393e48284ccb551f3a57c1395130385e7766b3ef0face83d68483</cites><orcidid>0000-0003-4952-9186</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fejn.15147$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fejn.15147$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,315,786,790,891,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33560561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Majewska, Ania</contributor><creatorcontrib>Ioghen, Octavian</creatorcontrib><creatorcontrib>Chițoiu, Leona</creatorcontrib><creatorcontrib>Gherghiceanu, Mihaela</creatorcontrib><creatorcontrib>Ceafalan, Laura Cristina</creatorcontrib><creatorcontrib>Hinescu, Mihail Eugen</creatorcontrib><creatorcontrib>Majewska, Ania</creatorcontrib><title>CD36 – A novel molecular target in the neurovascular unit</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>CD36 is an integral membrane protein primarily known for its function as a fatty acid transporter, yet also playing other biological roles from lipid metabolism to inflammation modulation. These pleiotropic effects are explained by the existence of multiple different ligands and the extensive distribution in numerous cell types. Moreover, the receptor is related to various pathologies and it may prove to be a good target for prospective therapeutic strategies. In the neurovascular unit (NVU), CD36 is expressed in cells like microglia, microvascular endothelial cells, astrocytes and neurons. In the normal brain, CD36 was proven to be involved in phagocytosis of apoptotic cells, oro‐sensory detection of dietary lipids, and fatty acid transport across the blood brain barrier (BBB). CD36 was also acknowledged as a potentially important player in central nervous system (CNS) disorders, such as Alzheimer Disease‐associated vascular dysfunction and oxidative stress and the neuroinflammatory response in stroke. Despite continuous efforts, the therapeutic arsenal for such diseases is still scarce and there is an increasing interest in discovering new molecular targets for more specific therapeutic approaches. In this review, we summarize the role of CD36 in the normal function of the NVU and in several CNS disorders, focusing on the dysregulation of the NVU and the potential therapeutic modulation.
CD36 is an integral membrane protein primarily known as a fatty acids transporter, yet also involved in lipid metabolism and inflammation. These pleiotropic effects are explained by its multiple ligands and its extensive distribution on numerous cell types. As CD36 participates both to the normal function and dysregulation of the neurovascular unit in several central nervous system disorders, it might prove to be a good target for prospective therapeutic strategies.</description><subject>Alzheimer Disease</subject><subject>Alzheimer's disease</subject><subject>Apoptosis</subject><subject>Astrocytes</subject><subject>Blood-brain barrier</subject><subject>CD36</subject><subject>CD36 antigen</subject><subject>Central nervous system</subject><subject>Endothelial cells</subject><subject>Fatty acids</subject><subject>Inflammation</subject><subject>Lipid metabolism</subject><subject>Membrane proteins</subject><subject>Microglia</subject><subject>Microvasculature</subject><subject>Molecular and Synaptic Mechanisms</subject><subject>Neurodegenerative diseases</subject><subject>neuroinflammation</subject><subject>neurovascular unit</subject><subject>Oxidative stress</subject><subject>Phagocytosis</subject><subject>Review</subject><subject>stroke</subject><subject>vascular dysfunction</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1kctKHEEUhouQkJmoC18gNGRjFq1VferWBAQZLzGIbmbhrqgpTzs99FSZqu4Rd76Db-iT2No6aCBncxbn4-M__IRsM7rL-tnDhd9lgnH1iYwZlzQvhdSfyZiWAnLN5OWIfEtpQSnVkouvZAQgJBWSjcmvySHI7PH-ITvIfFhhky1Dg65rbMxaG6-xzWqftXPMPHYxrGwabp2v203ypbJNwq3XvUGmx0fTye_87OLkdHJwljvOQeW6AAUzZUvQUAJyXWju3EwIVoEVyjEoBQMKWqBSUs4AK1pZhxqupOYaNsj-oL3pZku8cujbaBtzE-uljXcm2Np8vPh6bq7DyuiCK10WvWDnVRDD3w5Ta5Z1ctg01mPokim4VopzJZ_RH_-gi9BF339nCsG0VIxS1VM_B8rFkFLEah2GUfPciOkbMS-N9Oz39-nX5FsFPbA3ALd1g3f_N5mjP-eD8gnMBZPa</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Ioghen, Octavian</creator><creator>Chițoiu, Leona</creator><creator>Gherghiceanu, Mihaela</creator><creator>Ceafalan, Laura Cristina</creator><creator>Hinescu, Mihail Eugen</creator><creator>Majewska, Ania</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4952-9186</orcidid></search><sort><creationdate>202104</creationdate><title>CD36 – A novel molecular target in the neurovascular unit</title><author>Ioghen, Octavian ; Chițoiu, Leona ; Gherghiceanu, Mihaela ; Ceafalan, Laura Cristina ; Hinescu, Mihail Eugen ; Majewska, Ania</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4437-82373b7a938393e48284ccb551f3a57c1395130385e7766b3ef0face83d68483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alzheimer Disease</topic><topic>Alzheimer's disease</topic><topic>Apoptosis</topic><topic>Astrocytes</topic><topic>Blood-brain barrier</topic><topic>CD36</topic><topic>CD36 antigen</topic><topic>Central nervous system</topic><topic>Endothelial cells</topic><topic>Fatty acids</topic><topic>Inflammation</topic><topic>Lipid metabolism</topic><topic>Membrane proteins</topic><topic>Microglia</topic><topic>Microvasculature</topic><topic>Molecular and Synaptic Mechanisms</topic><topic>Neurodegenerative diseases</topic><topic>neuroinflammation</topic><topic>neurovascular unit</topic><topic>Oxidative stress</topic><topic>Phagocytosis</topic><topic>Review</topic><topic>stroke</topic><topic>vascular dysfunction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ioghen, Octavian</creatorcontrib><creatorcontrib>Chițoiu, Leona</creatorcontrib><creatorcontrib>Gherghiceanu, Mihaela</creatorcontrib><creatorcontrib>Ceafalan, Laura Cristina</creatorcontrib><creatorcontrib>Hinescu, Mihail Eugen</creatorcontrib><creatorcontrib>Majewska, Ania</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ioghen, Octavian</au><au>Chițoiu, Leona</au><au>Gherghiceanu, Mihaela</au><au>Ceafalan, Laura Cristina</au><au>Hinescu, Mihail Eugen</au><au>Majewska, Ania</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD36 – A novel molecular target in the neurovascular unit</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2021-04</date><risdate>2021</risdate><volume>53</volume><issue>8</issue><spage>2500</spage><epage>2510</epage><pages>2500-2510</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-1</notes><notes>These authors contributed equally to this work.</notes><abstract>CD36 is an integral membrane protein primarily known for its function as a fatty acid transporter, yet also playing other biological roles from lipid metabolism to inflammation modulation. These pleiotropic effects are explained by the existence of multiple different ligands and the extensive distribution in numerous cell types. Moreover, the receptor is related to various pathologies and it may prove to be a good target for prospective therapeutic strategies. In the neurovascular unit (NVU), CD36 is expressed in cells like microglia, microvascular endothelial cells, astrocytes and neurons. In the normal brain, CD36 was proven to be involved in phagocytosis of apoptotic cells, oro‐sensory detection of dietary lipids, and fatty acid transport across the blood brain barrier (BBB). CD36 was also acknowledged as a potentially important player in central nervous system (CNS) disorders, such as Alzheimer Disease‐associated vascular dysfunction and oxidative stress and the neuroinflammatory response in stroke. Despite continuous efforts, the therapeutic arsenal for such diseases is still scarce and there is an increasing interest in discovering new molecular targets for more specific therapeutic approaches. In this review, we summarize the role of CD36 in the normal function of the NVU and in several CNS disorders, focusing on the dysregulation of the NVU and the potential therapeutic modulation.
CD36 is an integral membrane protein primarily known as a fatty acids transporter, yet also involved in lipid metabolism and inflammation. These pleiotropic effects are explained by its multiple ligands and its extensive distribution on numerous cell types. As CD36 participates both to the normal function and dysregulation of the neurovascular unit in several central nervous system disorders, it might prove to be a good target for prospective therapeutic strategies.</abstract><cop>France</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33560561</pmid><doi>10.1111/ejn.15147</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-4952-9186</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0953-816X |
| ispartof | The European journal of neuroscience, 2021-04, Vol.53 (8), p.2500-2510 |
| issn | 0953-816X 1460-9568 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8247892 |
| source | Wiley-Blackwell Journals |
| subjects | Alzheimer Disease Alzheimer's disease Apoptosis Astrocytes Blood-brain barrier CD36 CD36 antigen Central nervous system Endothelial cells Fatty acids Inflammation Lipid metabolism Membrane proteins Microglia Microvasculature Molecular and Synaptic Mechanisms Neurodegenerative diseases neuroinflammation neurovascular unit Oxidative stress Phagocytosis Review stroke vascular dysfunction |
| title | CD36 – A novel molecular target in the neurovascular unit |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T10%3A57%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CD36%20%E2%80%93%20A%20novel%20molecular%20target%20in%20the%20neurovascular%20unit&rft.jtitle=The%20European%20journal%20of%20neuroscience&rft.au=Ioghen,%20Octavian&rft.date=2021-04&rft.volume=53&rft.issue=8&rft.spage=2500&rft.epage=2510&rft.pages=2500-2510&rft.issn=0953-816X&rft.eissn=1460-9568&rft_id=info:doi/10.1111/ejn.15147&rft_dat=%3Cproquest_pubme%3E2487744762%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4437-82373b7a938393e48284ccb551f3a57c1395130385e7766b3ef0face83d68483%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2518671007&rft_id=info:pmid/33560561&rfr_iscdi=true |