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A Functional Polymorphism in HIF-3α Is Related to an Increased Risk of Ischemic Stroke
Hypoxia-inducible factor-3α ( HIF-3α ), a member of HIF family, can mediate adaptive responses to low oxygen and ischemia. It is believed that HIF plays crucial roles in stroke-related diseases. However, there are no reports on the association between HIF-3α genetic variants and ischemic stroke (IS)...
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Published in: | Journal of molecular neuroscience 2021-05, Vol.71 (5), p.1061-1069 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Hypoxia-inducible factor-3α (
HIF-3α
), a member of HIF family, can mediate adaptive responses to low oxygen and ischemia. It is believed that HIF plays crucial roles in stroke-related diseases. However, there are no reports on the association between HIF-3α genetic variants and ischemic stroke (IS) susceptibility. Therefore, we examined the association between
HIF-
3α gene polymorphisms (rs3826795, rs2235095, and rs3764609) and IS risk. The study population included 302 controls and 310 patients with ischemic stroke. Three polymorphisms in
HIF-
3α (rs3826795, rs2235095, and rs3764609) were genotyped using SNPscan technique. Our study showed a strong association of rs3826795 in HIF-3α with the risk of IS. The genotype and allele frequencies were shown to differ between the two groups. The rs3826795 in an intron of
HIF-3α
was related to a prominent increased IS risk (AA vs GG adjusted odd ratio [OR], 2.21; 95% confidence intervals [95% CI], 1.10–4.44;
P
= 0.03; AA vs AG/GG OR = 1.74, 95% CI, 1.02–2.97,
P
= 0.04; A vs G OR = 1.48, 95% CI, 1.05–2.07,
P
= 0.02). Logistic regression analysis suggested that rs3826795 posed a risk factor for IS in addition to common factors. Furthermore, when compared to controls, increased levels of homocysteic acid and level of non-esterified fatty acid were found in the cases (
P
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ISSN: | 0895-8696 1559-1166 |
DOI: | 10.1007/s12031-020-01728-z |