COVID-19 and Cardiovascular Disease: From Bench to Bedside

A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can infect the heart, vascu...

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Bibliographic Details
Published in:Circulation research 2021-04, Vol.128 (8), p.1214-1236
Main Authors: Chung, Mina K, Zidar, David A, Bristow, Michael R, Cameron, Scott J, Chan, Timothy, Harding, 3rd, Clifford V, Kwon, Deborah H, Singh, Tamanna, Tilton, John C, Tsai, Emily J, Tucker, Nathan R, Barnard, John, Loscalzo, Joseph
Format: Article
Language:English
Subjects:
Angiotensin-Converting Enzyme 2 - metabolism
Biomarkers - metabolism
Cardiomyopathies - virology
Cardiovascular Diseases - virology
COVID-19 - complications
COVID-19 - epidemiology
COVID-19 - therapy
COVID-19 - virology
Gene Expression
Humans
Immune System - physiology
Myocardium - enzymology
Myocytes, Cardiac - enzymology
Myocytes, Cardiac - virology
Neuropilin-1 - metabolism
Platelet Activation
Renin-Angiotensin System - physiology
Return to Sport
Review
Risk Factors
RNA, Messenger - metabolism
SARS-CoV-2 - physiology
SARS-CoV-2 - ultrastructure
Spike Glycoprotein, Coronavirus - metabolism
Troponin - metabolism
Ventricular Remodeling
Virus Attachment
Virus Internalization - drug effects
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Summary:A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can infect the heart, vascular tissues, and circulating cells through ACE2 (angiotensin-converting enzyme 2), the host cell receptor for the viral spike protein. Acute cardiac injury is a common extrapulmonary manifestation of COVID-19 with potential chronic consequences. This update provides a review of the clinical manifestations of cardiovascular involvement, potential direct SARS-CoV-2 and indirect immune response mechanisms impacting the cardiovascular system, and implications for the management of patients after recovery from acute COVID-19 infection.
ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.121.317997