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Reliable Callosal Measurement: Population Normative Data Confirm Sex-Related Differences
Corpus callosal cross-sectional area (CCA) may be a clinical indicator of disease progression, but factors influencing callosal morphology in healthy subjects must be determined before comparisons can be made in patients. We sought to define a reliable and easily repeatable method for CCA measuremen...
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| Published in: | American journal of neuroradiology : AJNR 2003-03, Vol.24 (3), p.410-418 |
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| container_title | American journal of neuroradiology : AJNR |
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| creator | Mitchell, Tejal N Free, Samantha L Merschhemke, Martin Lemieux, Louis Sisodiya, Sanjay M Shorvon, Simon D |
| description | Corpus callosal cross-sectional area (CCA) may be a clinical indicator of disease progression, but factors influencing callosal morphology in healthy subjects must be determined before comparisons can be made in patients. We sought to define a reliable and easily repeatable method for CCA measurement and to examine the effects of sex, age, handedness, and cerebral volume.
Neurologically healthy volunteers (age range, 14-68 years; mean age, 32.6 years +/- 12.3 [SD]; 44 men, 56 women; 87 right handed) underwent conventional MR imaging. Data were reoriented in the image space to account for intersubject variations in head position before the midsagittal plane was defined by using midpoints of the anterior commissure (AC), posterior commissure (PC), and interhemispheric fissure (IF). Midsagittal CCA and total cerebral volume were measured and correlated with sex, age, and handedness.
The mean CCA was 6.27 cm(2) +/- 0.90. Women had a larger CCA proportional to cerebral volume (6.16 x 10(-3) cm(-1) vs 5.78 x 10(-3) cm(-1) in men; P =.02). The percentage difference for the CCA-cerebral volume from the group mean was +2.6% in women and -3.6% in men. Only a small linear relationship of CCA with cerebral volume was noted (r(2) = 0.15), and CCA was not significantly correlated with age or handedness.
To our knowledge, this is the largest study of callosal area in a community-based sample of control subjects; such subjects provide controls for future studies. Our findings provide anatomic evidence of sex differences in interhemispheric connectivity. Much CCA variability is independent of cerebral volume. |
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Neurologically healthy volunteers (age range, 14-68 years; mean age, 32.6 years +/- 12.3 [SD]; 44 men, 56 women; 87 right handed) underwent conventional MR imaging. Data were reoriented in the image space to account for intersubject variations in head position before the midsagittal plane was defined by using midpoints of the anterior commissure (AC), posterior commissure (PC), and interhemispheric fissure (IF). Midsagittal CCA and total cerebral volume were measured and correlated with sex, age, and handedness.
The mean CCA was 6.27 cm(2) +/- 0.90. Women had a larger CCA proportional to cerebral volume (6.16 x 10(-3) cm(-1) vs 5.78 x 10(-3) cm(-1) in men; P =.02). The percentage difference for the CCA-cerebral volume from the group mean was +2.6% in women and -3.6% in men. Only a small linear relationship of CCA with cerebral volume was noted (r(2) = 0.15), and CCA was not significantly correlated with age or handedness.
To our knowledge, this is the largest study of callosal area in a community-based sample of control subjects; such subjects provide controls for future studies. Our findings provide anatomic evidence of sex differences in interhemispheric connectivity. Much CCA variability is independent of cerebral volume.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>PMID: 12637291</identifier><identifier>CODEN: AAJNDL</identifier><language>eng</language><publisher>Oak Brook, IL: Am Soc Neuroradiology</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Brain ; Corpus Callosum - anatomy & histology ; Dominance, Cerebral - physiology ; Female ; Humans ; Image Interpretation, Computer-Assisted ; Imaging, Three-Dimensional - methods ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; Nervous system ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Reference Values ; Reproducibility of Results ; Sex Characteristics</subject><ispartof>American journal of neuroradiology : AJNR, 2003-03, Vol.24 (3), p.410-418</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright © American Society of Neuroradiology 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973608/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973608/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,53827,53829</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14663494$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12637291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitchell, Tejal N</creatorcontrib><creatorcontrib>Free, Samantha L</creatorcontrib><creatorcontrib>Merschhemke, Martin</creatorcontrib><creatorcontrib>Lemieux, Louis</creatorcontrib><creatorcontrib>Sisodiya, Sanjay M</creatorcontrib><creatorcontrib>Shorvon, Simon D</creatorcontrib><title>Reliable Callosal Measurement: Population Normative Data Confirm Sex-Related Differences</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>Corpus callosal cross-sectional area (CCA) may be a clinical indicator of disease progression, but factors influencing callosal morphology in healthy subjects must be determined before comparisons can be made in patients. We sought to define a reliable and easily repeatable method for CCA measurement and to examine the effects of sex, age, handedness, and cerebral volume.
Neurologically healthy volunteers (age range, 14-68 years; mean age, 32.6 years +/- 12.3 [SD]; 44 men, 56 women; 87 right handed) underwent conventional MR imaging. Data were reoriented in the image space to account for intersubject variations in head position before the midsagittal plane was defined by using midpoints of the anterior commissure (AC), posterior commissure (PC), and interhemispheric fissure (IF). Midsagittal CCA and total cerebral volume were measured and correlated with sex, age, and handedness.
The mean CCA was 6.27 cm(2) +/- 0.90. Women had a larger CCA proportional to cerebral volume (6.16 x 10(-3) cm(-1) vs 5.78 x 10(-3) cm(-1) in men; P =.02). The percentage difference for the CCA-cerebral volume from the group mean was +2.6% in women and -3.6% in men. Only a small linear relationship of CCA with cerebral volume was noted (r(2) = 0.15), and CCA was not significantly correlated with age or handedness.
To our knowledge, this is the largest study of callosal area in a community-based sample of control subjects; such subjects provide controls for future studies. Our findings provide anatomic evidence of sex differences in interhemispheric connectivity. Much CCA variability is independent of cerebral volume.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Corpus Callosum - anatomy & histology</subject><subject>Dominance, Cerebral - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Reference Values</subject><subject>Reproducibility of Results</subject><subject>Sex Characteristics</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpVkE1P3DAQhiPUCpaFv4ByobdI_ooTc6iEFiiVoK34kPZmzdpj1pUTb-2Epf-eSN0WepqR5tHzjt69YkYVl5Wq1fJDMSNU1ZWkpD0oDnP-SQipVcP2iwPKJG-YorNieYfBwypguYAQYoZQ3iLkMWGH_XBW_oibMcDgY19-i6mbtmcsL2CAchF751NX3uNLNUlgQFteeOcwYW8wHxUfHYSMx7s5Lx6vLh8W19XN9y9fF-c31ZozNlRGgUPBJCPWylrwxjVgV7StZWu5civXIhVSMMulaA1DI8AYayS00tQtWD4vPv_xbsZVh9ZMXycIepN8B-m3juD1_5fer_VTfNaNargk7ST4tBOk-GvEPOjOZ4MhQI9xzLrhlAjZyAk8eZ_0L-JvmRNwugMgGwguQW98fuOElFwo8cat_dN66xPq3E3lT1qqt9stE5prQQl_BZBljhI</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Mitchell, Tejal N</creator><creator>Free, Samantha L</creator><creator>Merschhemke, Martin</creator><creator>Lemieux, Louis</creator><creator>Sisodiya, Sanjay M</creator><creator>Shorvon, Simon D</creator><general>Am Soc Neuroradiology</general><general>American Society of Neuroradiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20030301</creationdate><title>Reliable Callosal Measurement: Population Normative Data Confirm Sex-Related Differences</title><author>Mitchell, Tejal N ; Free, Samantha L ; Merschhemke, Martin ; Lemieux, Louis ; Sisodiya, Sanjay M ; Shorvon, Simon D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h322t-c9afe42620dd65437f7adb18568d39fbf8e14642d3648c2ec4accdc6a86c58ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Corpus Callosum - anatomy & histology</topic><topic>Dominance, Cerebral - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Reference Values</topic><topic>Reproducibility of Results</topic><topic>Sex Characteristics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitchell, Tejal N</creatorcontrib><creatorcontrib>Free, Samantha L</creatorcontrib><creatorcontrib>Merschhemke, Martin</creatorcontrib><creatorcontrib>Lemieux, Louis</creatorcontrib><creatorcontrib>Sisodiya, Sanjay M</creatorcontrib><creatorcontrib>Shorvon, Simon D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitchell, Tejal N</au><au>Free, Samantha L</au><au>Merschhemke, Martin</au><au>Lemieux, Louis</au><au>Sisodiya, Sanjay M</au><au>Shorvon, Simon D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reliable Callosal Measurement: Population Normative Data Confirm Sex-Related Differences</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>24</volume><issue>3</issue><spage>410</spage><epage>418</epage><pages>410-418</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><coden>AAJNDL</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Corpus callosal cross-sectional area (CCA) may be a clinical indicator of disease progression, but factors influencing callosal morphology in healthy subjects must be determined before comparisons can be made in patients. We sought to define a reliable and easily repeatable method for CCA measurement and to examine the effects of sex, age, handedness, and cerebral volume.
Neurologically healthy volunteers (age range, 14-68 years; mean age, 32.6 years +/- 12.3 [SD]; 44 men, 56 women; 87 right handed) underwent conventional MR imaging. Data were reoriented in the image space to account for intersubject variations in head position before the midsagittal plane was defined by using midpoints of the anterior commissure (AC), posterior commissure (PC), and interhemispheric fissure (IF). Midsagittal CCA and total cerebral volume were measured and correlated with sex, age, and handedness.
The mean CCA was 6.27 cm(2) +/- 0.90. Women had a larger CCA proportional to cerebral volume (6.16 x 10(-3) cm(-1) vs 5.78 x 10(-3) cm(-1) in men; P =.02). The percentage difference for the CCA-cerebral volume from the group mean was +2.6% in women and -3.6% in men. Only a small linear relationship of CCA with cerebral volume was noted (r(2) = 0.15), and CCA was not significantly correlated with age or handedness.
To our knowledge, this is the largest study of callosal area in a community-based sample of control subjects; such subjects provide controls for future studies. Our findings provide anatomic evidence of sex differences in interhemispheric connectivity. Much CCA variability is independent of cerebral volume.</abstract><cop>Oak Brook, IL</cop><pub>Am Soc Neuroradiology</pub><pmid>12637291</pmid><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Brain Corpus Callosum - anatomy & histology Dominance, Cerebral - physiology Female Humans Image Interpretation, Computer-Assisted Imaging, Three-Dimensional - methods Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Nervous system Radiodiagnosis. Nmr imagery. Nmr spectrometry Reference Values Reproducibility of Results Sex Characteristics |
| title | Reliable Callosal Measurement: Population Normative Data Confirm Sex-Related Differences |
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