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Brachionus rotifers as a model for investigating dietary and metabolic regulators of aging
Because every species has unique attributes relevant to understanding specific aspects of aging, using a diversity of study systems and a comparative biology approach for aging research has the potential to lead to novel discoveries applicable to human health. Monogonont rotifers, a standard model f...
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| Published in: | Nutrition and healthy aging 2021-01, Vol.6 (1), p.1-15 |
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| container_title | Nutrition and healthy aging |
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| creator | Gribble, Kristin E |
| description | Because every species has unique attributes relevant to understanding specific aspects of aging, using a diversity of study systems and a comparative biology approach for aging research has the potential to lead to novel discoveries applicable to human health. Monogonont rotifers, a standard model for studies of aquatic ecology, evolutionary biology, and ecotoxicology, have also been used to study lifespan and healthspan for nearly a century. However, because much of this work has been published in the ecology and evolutionary biology literature, it may not be known to the biomedical research community. In this review, we provide an overview of
rotifers as a model to investigate nutritional and metabolic regulators of aging, with a focus on recent studies of dietary and metabolic pathway manipulation. Rotifers are microscopic, aquatic invertebrates with many advantages as a system for studying aging, including a two-week lifespan, easy laboratory culture, direct development without a larval stage, sexual and asexual reproduction, easy delivery of pharmaceuticals in liquid culture, and transparency allowing imaging of cellular morphology and processes. Rotifers have greater gene homology with humans than do established invertebrate models for aging, and thus rotifers may be used to investigate novel genetic mechanisms relevant to human lifespan and healthspan. The research on caloric restriction; dietary, pharmaceutical, and genetic interventions; and transcriptomics of aging using rotifers provide insights into the metabolic regulators of lifespan and health and suggest future directions for aging research. Capitalizing on the unique biology of
rotifers, referencing the vast existing literature about the influence of diet and drugs on rotifer lifespan and health, continuing the development of genetic tools for rotifers, and growing the rotifer research community will lead to new discoveries a better understanding of the biology of aging. |
| doi_str_mv | 10.3233/NHA-200104 |
| format | article |
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rotifers as a model to investigate nutritional and metabolic regulators of aging, with a focus on recent studies of dietary and metabolic pathway manipulation. Rotifers are microscopic, aquatic invertebrates with many advantages as a system for studying aging, including a two-week lifespan, easy laboratory culture, direct development without a larval stage, sexual and asexual reproduction, easy delivery of pharmaceuticals in liquid culture, and transparency allowing imaging of cellular morphology and processes. Rotifers have greater gene homology with humans than do established invertebrate models for aging, and thus rotifers may be used to investigate novel genetic mechanisms relevant to human lifespan and healthspan. The research on caloric restriction; dietary, pharmaceutical, and genetic interventions; and transcriptomics of aging using rotifers provide insights into the metabolic regulators of lifespan and health and suggest future directions for aging research. Capitalizing on the unique biology of
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rotifers as a model to investigate nutritional and metabolic regulators of aging, with a focus on recent studies of dietary and metabolic pathway manipulation. Rotifers are microscopic, aquatic invertebrates with many advantages as a system for studying aging, including a two-week lifespan, easy laboratory culture, direct development without a larval stage, sexual and asexual reproduction, easy delivery of pharmaceuticals in liquid culture, and transparency allowing imaging of cellular morphology and processes. Rotifers have greater gene homology with humans than do established invertebrate models for aging, and thus rotifers may be used to investigate novel genetic mechanisms relevant to human lifespan and healthspan. The research on caloric restriction; dietary, pharmaceutical, and genetic interventions; and transcriptomics of aging using rotifers provide insights into the metabolic regulators of lifespan and health and suggest future directions for aging research. Capitalizing on the unique biology of
rotifers, referencing the vast existing literature about the influence of diet and drugs on rotifer lifespan and health, continuing the development of genetic tools for rotifers, and growing the rotifer research community will lead to new discoveries a better understanding of the biology of aging.</description><subject>Aging</subject><subject>Aquatic ecology</subject><subject>Aquatic organisms</subject><subject>Asexual reproduction</subject><subject>Biological evolution</subject><subject>Biology</subject><subject>Brachionus</subject><subject>Cell culture</subject><subject>Culture</subject><subject>Developmental stages</subject><subject>Diet</subject><subject>Dietary restrictions</subject><subject>Drug development</subject><subject>Ecotoxicology</subject><subject>Evolutionary biology</subject><subject>Homology</subject><subject>Invertebrates</subject><subject>Laboratory culture</subject><subject>Life span</subject><subject>Liquid culture</subject><subject>Metabolic pathways</subject><subject>Metabolism</subject><subject>Morphology</subject><subject>Pharmaceuticals</subject><subject>Regulators</subject><subject>Reproduction (biology)</subject><subject>Review</subject><subject>Rotifera</subject><issn>2451-9480</issn><issn>2451-9502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVkV9LwzAUxYMoTuZe_AAS8E2o3iTN2rwIc6gThr7oiy8hTdMuo2tm0g789mbsD0pCciG_nJzcg9AVgTtGGbt_m00SCkAgPUEXNOUkERzo6aFOcxigUQhLiEzGOQd-jgaMZSAgJRfo69ErvbCu7QP2rrOV8QGrOPHKlabBlfPYthsTOlurzrY1Lq3plP_Bqi3xKpaFa6zG3tR9ozoXb7sKqzqSl-isUk0wo_0-RJ_PTx_TWTJ_f3mdTuaJZpSkiQIogIHRAEIwriHPSk2yygjNGSlNWcA4jwszbKzzMdcUKg2FoJrlRqTAhuhhp7vui5UptWk7rxq59nYVfUqnrPx_0tqFrN1GZgJY7FIUuNkLePfdx6_Kpet9Gz1LmmYijoxuqdsdpb0LwZvq-AIBuY1CxijkLooIX__1dEQPjWe_HfmEgQ</recordid><startdate>20210120</startdate><enddate>20210120</enddate><creator>Gribble, Kristin E</creator><general>IOS Press BV</general><general>IOS 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stages</topic><topic>Diet</topic><topic>Dietary restrictions</topic><topic>Drug development</topic><topic>Ecotoxicology</topic><topic>Evolutionary biology</topic><topic>Homology</topic><topic>Invertebrates</topic><topic>Laboratory culture</topic><topic>Life span</topic><topic>Liquid culture</topic><topic>Metabolic pathways</topic><topic>Metabolism</topic><topic>Morphology</topic><topic>Pharmaceuticals</topic><topic>Regulators</topic><topic>Reproduction (biology)</topic><topic>Review</topic><topic>Rotifera</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gribble, Kristin E</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research 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of aging, using a diversity of study systems and a comparative biology approach for aging research has the potential to lead to novel discoveries applicable to human health. 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rotifers as a model to investigate nutritional and metabolic regulators of aging, with a focus on recent studies of dietary and metabolic pathway manipulation. Rotifers are microscopic, aquatic invertebrates with many advantages as a system for studying aging, including a two-week lifespan, easy laboratory culture, direct development without a larval stage, sexual and asexual reproduction, easy delivery of pharmaceuticals in liquid culture, and transparency allowing imaging of cellular morphology and processes. Rotifers have greater gene homology with humans than do established invertebrate models for aging, and thus rotifers may be used to investigate novel genetic mechanisms relevant to human lifespan and healthspan. The research on caloric restriction; dietary, pharmaceutical, and genetic interventions; and transcriptomics of aging using rotifers provide insights into the metabolic regulators of lifespan and health and suggest future directions for aging research. Capitalizing on the unique biology of
rotifers, referencing the vast existing literature about the influence of diet and drugs on rotifer lifespan and health, continuing the development of genetic tools for rotifers, and growing the rotifer research community will lead to new discoveries a better understanding of the biology of aging.</abstract><cop>Netherlands</cop><pub>IOS Press BV</pub><pmid>33709041</pmid><doi>10.3233/NHA-200104</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrition and healthy aging, 2021-01, Vol.6 (1), p.1-15 |
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| source | DOAJ Directory of Open Access Journals |
| subjects | Aging Aquatic ecology Aquatic organisms Asexual reproduction Biological evolution Biology Brachionus Cell culture Culture Developmental stages Diet Dietary restrictions Drug development Ecotoxicology Evolutionary biology Homology Invertebrates Laboratory culture Life span Liquid culture Metabolic pathways Metabolism Morphology Pharmaceuticals Regulators Reproduction (biology) Review Rotifera |
| title | Brachionus rotifers as a model for investigating dietary and metabolic regulators of aging |
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