The impact of SARS-CoV-2 on the cystic fibrosis foundation therapeutics development network

•The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) global pandemic has significantly impacted CF clinical research.•An electronic survey was sent to Therapeutic Development Network (TDN) sites to monitor the impact.•SARS-CoV-2 had an early impact on participant enrollment, research team...

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Bibliographic Details
Published in:Journal of cystic fibrosis 2021-03, Vol.20 (2), p.195-197
Main Authors: Pearson, Kelsie, Mayer-Hamblett, Nicole, Goss, Christopher H., Retsch-Bogart, George Z., VanDalfsen, Jill M., Burks, Patricia, Rosenbluth, Daniel, Clancy, John Paul, Hoffman, Amy, Nichols, David P.
Format: Article
Language:English
Subjects:
Biomedical Research - organization & administration
Clinical research
Coronavirus
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 - transmission
Cystic fibrosis
Cystic Fibrosis - therapy
Foundations
Humans
Research Design
SARS-CoV-2
Short Communication
Spirometry
Surveys and Questionnaires
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Summary:•The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) global pandemic has significantly impacted CF clinical research.•An electronic survey was sent to Therapeutic Development Network (TDN) sites to monitor the impact.•SARS-CoV-2 had an early impact on participant enrollment, research team stability, and procedures such as spirometry and sputum induction.•Trends steadily improved over the months as research activities began to recover across the TDN.•SARS-CoV-2 highlights new opportunities to expand CF research focusing on data collection outside of research centers and increased access for remote participation. The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) global pandemic significantly impacted CF clinical research within the Cystic Fibrosis Foundation Therapeutics Development Network (CFF TDN). A Research Electronic Data Capture (REDCap) survey was developed and sent to network sites to monitor and understand the impact on research teams, ongoing and anticipated clinical research, and specific clinical and research procedures. Key findings indicated an early impact on participant enrollment, research team stability, and procedures such as spirometry and sputum induction. These trends steadily improved over the months as research activities began to recover across the TDN. While SARS-CoV-2 created a significant challenge it also highlights new opportunities to expand CF research with greater focus on data collection outside of research centers and increased access for remote participation.
ISSN:1569-1993
1873-5010
DOI:10.1016/j.jcf.2020.12.007