COVID-19 endocrinopathy with hindsight from SARS

The current COVID-19 pandemic is probably the worst the world has ever faced since the start of the new millennium. Although the respiratory system is the most prominent target of SARS-CoV-2 (the contagion of COVID-19), extrapulmonary involvement are emerging as important contributors of its morbidi...

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2021-01, Vol.320 (1), p.E139-E150
Main Authors: Kothandaraman, Narasimhan, Rengaraj, Anantharaj, Xue, Bo, Yew, Wen Shan, Velan, S Sendhil, Karnani, Neerja, Leow, Melvin Khee Shing
Format: Article
Language:English
Subjects:
Angiotensin-Converting Enzyme 2
Coronaviridae
Coronaviruses
COVID-19
COVID-19 - complications
Diabetes mellitus
Endocrine disorders
Endocrine system
Endocrine System Diseases - virology
Humans
Lethality
Morbidity
Neuropilin-1
Pandemics
Reproductive system
Respiratory system
Review
SARS Virus
SARS-CoV-2
Serine Endopeptidases
Severe Acute Respiratory Syndrome
Severe acute respiratory syndrome coronavirus 2
Thyroid
Viral diseases
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Summary:The current COVID-19 pandemic is probably the worst the world has ever faced since the start of the new millennium. Although the respiratory system is the most prominent target of SARS-CoV-2 (the contagion of COVID-19), extrapulmonary involvement are emerging as important contributors of its morbidity and lethality. This article summarizes the impact of SARS-CoV and SARS-CoV-2 on the endocrine system to facilitate our understanding of the nature of coronavirus-associated endocrinopathy. Although new data are rapidly accumulating on this novel infection, many of the endocrine manifestations of COVID-19 remain incompletely elucidated. We, hereby, summarize various endocrine dysfunctions including coronavirus-induced new onset diabetes mellitus, hypocortisolism, thyroid hormone, and reproductive system aberrations so that clinicians armed with such insights can potentially benefit patients with COVID-19 at the bedside.
ISSN:0193-1849
1522-1555
DOI:10.1152/AJPENDO.00480.2020