Loading…

Minding the treatment gap: results of the Singapore Mental Health Study

Purpose To establish the 12-month treatment gap and its associated factors among adults with mental disorders in the Singapore resident population using data from the second Singapore Mental Health Study and to examine the changes since the last mental health survey conducted in 2010. Methods 6126 r...

Full description

Saved in:
Bibliographic Details
Published in:Social Psychiatry and Psychiatric Epidemiology 2020-11, Vol.55 (11), p.1415-1424
Main Authors: Subramaniam, Mythily, Abdin, Edimansyah, Vaingankar, Janhavi Ajit, Shafie, Saleha, Chua, Hong Choon, Tan, Weng Mooi, Tan, Kelvin Bryan, Verma, Swapna, Heng, Derrick, Chong, Siow Ann
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c569t-fccd12b01bc9e08a38aa4fa5bc9dfa6b77494c86b158c90003250aaa127562653
cites cdi_FETCH-LOGICAL-c569t-fccd12b01bc9e08a38aa4fa5bc9dfa6b77494c86b158c90003250aaa127562653
container_end_page 1424
container_issue 11
container_start_page 1415
container_title Social Psychiatry and Psychiatric Epidemiology
container_volume 55
creator Subramaniam, Mythily
Abdin, Edimansyah
Vaingankar, Janhavi Ajit
Shafie, Saleha
Chua, Hong Choon
Tan, Weng Mooi
Tan, Kelvin Bryan
Verma, Swapna
Heng, Derrick
Chong, Siow Ann
description Purpose To establish the 12-month treatment gap and its associated factors among adults with mental disorders in the Singapore resident population using data from the second Singapore Mental Health Study and to examine the changes since the last mental health survey conducted in 2010. Methods 6126 respondents were administered selected modules of the Composite International Diagnostic Interview, to assess major depressive disorder (MDD), dysthymia, bipolar disorder, generalized anxiety disorder (GAD), obsessive compulsive disorder (OCD) and alcohol use disorder (AUD) (which included alcohol abuse and dependence). Past year treatment gap was defined as the absolute difference between the prevalence of a particular mental disorder in the past 12 months preceding the interview and those who had received treatment for that disorder. Results The prevalence of overall 12-month treatment gap in this population was high (78.6%). A multiple logistic regression analysis revealed significantly higher odds of treatment gap among those diagnosed with OCD (compared to those with MDD) and in those with a comorbid chronic physical disorder; while those who had primary education and below and those who were unemployed were less likely to have a treatment gap as compared to those with post-secondary education and those employed, respectively. Conclusions The high treatment gap in the population is concerning and highlights the need to promote help-seeking and uptake of treatment. Given the unique demographic characteristics, i.e., those with higher education and employed were more likely not to seek treatment, targeted interventions in the educational and workplace settings should be implemented.
doi_str_mv 10.1007/s00127-019-01748-0
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7578124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A716433193</galeid><sourcerecordid>A716433193</sourcerecordid><originalsourceid>FETCH-LOGICAL-c569t-fccd12b01bc9e08a38aa4fa5bc9dfa6b77494c86b158c90003250aaa127562653</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhi0EosvCH-CAInHhkuLPOOaAVFXQVmrFoXC2Jo6TdZXEi51U6r9ntltaWqFqFMXJPPN6xn4Jec_oIaNUf86UMq5Lygw-WtYlfUFWTApRGl6rl2RFDa61UfKAvMn5ilIqjBavyYFggmkuqxU5uQhTG6a-mDe-mJOHefTTXPSw_VIkn5dhzkXsbrOXiME2Jl9cIAJDcephmDfF5by0N2_Jqw6G7N_dvdfk1_dvP49Py_MfJ2fHR-elU5WZy865lvGGssYZT2sQNYDsQOFn20HVaC2NdHXVMFU7s2uYKwoAOKeqeKXEmnzd626XZvStw04SDHabwgjpxkYI9nFmChvbx2urla4Zlyjw6U4gxd-Lz7MdQ3Z-GGDyccmWc2UM53VVIfrxCXoVlzTheJZLzRQGZc9SqMWY0JI_UD0M3oapi9id221tjzSr8NIYXtaaHP6Hwmj9GFycfBfw_6MCvi9wKeacfHd_EozanUns3iQWTWJvTWIpFn349wzvS_66AgGxBzKmpt6nh5Gekf0D5LrEkQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2259113742</pqid></control><display><type>article</type><title>Minding the treatment gap: results of the Singapore Mental Health Study</title><source>Springer Link</source><creator>Subramaniam, Mythily ; Abdin, Edimansyah ; Vaingankar, Janhavi Ajit ; Shafie, Saleha ; Chua, Hong Choon ; Tan, Weng Mooi ; Tan, Kelvin Bryan ; Verma, Swapna ; Heng, Derrick ; Chong, Siow Ann</creator><creatorcontrib>Subramaniam, Mythily ; Abdin, Edimansyah ; Vaingankar, Janhavi Ajit ; Shafie, Saleha ; Chua, Hong Choon ; Tan, Weng Mooi ; Tan, Kelvin Bryan ; Verma, Swapna ; Heng, Derrick ; Chong, Siow Ann</creatorcontrib><description>Purpose To establish the 12-month treatment gap and its associated factors among adults with mental disorders in the Singapore resident population using data from the second Singapore Mental Health Study and to examine the changes since the last mental health survey conducted in 2010. Methods 6126 respondents were administered selected modules of the Composite International Diagnostic Interview, to assess major depressive disorder (MDD), dysthymia, bipolar disorder, generalized anxiety disorder (GAD), obsessive compulsive disorder (OCD) and alcohol use disorder (AUD) (which included alcohol abuse and dependence). Past year treatment gap was defined as the absolute difference between the prevalence of a particular mental disorder in the past 12 months preceding the interview and those who had received treatment for that disorder. Results The prevalence of overall 12-month treatment gap in this population was high (78.6%). A multiple logistic regression analysis revealed significantly higher odds of treatment gap among those diagnosed with OCD (compared to those with MDD) and in those with a comorbid chronic physical disorder; while those who had primary education and below and those who were unemployed were less likely to have a treatment gap as compared to those with post-secondary education and those employed, respectively. Conclusions The high treatment gap in the population is concerning and highlights the need to promote help-seeking and uptake of treatment. Given the unique demographic characteristics, i.e., those with higher education and employed were more likely not to seek treatment, targeted interventions in the educational and workplace settings should be implemented.</description><identifier>ISSN: 0933-7954</identifier><identifier>EISSN: 1433-9285</identifier><identifier>DOI: 10.1007/s00127-019-01748-0</identifier><identifier>PMID: 31317246</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Alcohol ; Alcohol abuse ; Alcohol use ; Analysis ; Anxiety ; Bipolar disorder ; Care and treatment ; Demographics ; Dependence ; Diagnostic systems ; Education ; Epidemiology ; Health surveys ; Medicine ; Medicine &amp; Public Health ; Mental disorders ; Mental health ; Obsessive compulsive disorder ; Original Paper ; Psychiatry ; Regression analysis ; Substance abuse ; Surveys</subject><ispartof>Social Psychiatry and Psychiatric Epidemiology, 2020-11, Vol.55 (11), p.1415-1424</ispartof><rights>The Author(s) 2019</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Social Psychiatry and Psychiatric Epidemiology is a copyright of Springer, (2019). All Rights Reserved. © 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-fccd12b01bc9e08a38aa4fa5bc9dfa6b77494c86b158c90003250aaa127562653</citedby><cites>FETCH-LOGICAL-c569t-fccd12b01bc9e08a38aa4fa5bc9dfa6b77494c86b158c90003250aaa127562653</cites><orcidid>0000-0003-4530-1096</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31317246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Subramaniam, Mythily</creatorcontrib><creatorcontrib>Abdin, Edimansyah</creatorcontrib><creatorcontrib>Vaingankar, Janhavi Ajit</creatorcontrib><creatorcontrib>Shafie, Saleha</creatorcontrib><creatorcontrib>Chua, Hong Choon</creatorcontrib><creatorcontrib>Tan, Weng Mooi</creatorcontrib><creatorcontrib>Tan, Kelvin Bryan</creatorcontrib><creatorcontrib>Verma, Swapna</creatorcontrib><creatorcontrib>Heng, Derrick</creatorcontrib><creatorcontrib>Chong, Siow Ann</creatorcontrib><title>Minding the treatment gap: results of the Singapore Mental Health Study</title><title>Social Psychiatry and Psychiatric Epidemiology</title><addtitle>Soc Psychiatry Psychiatr Epidemiol</addtitle><addtitle>Soc Psychiatry Psychiatr Epidemiol</addtitle><description>Purpose To establish the 12-month treatment gap and its associated factors among adults with mental disorders in the Singapore resident population using data from the second Singapore Mental Health Study and to examine the changes since the last mental health survey conducted in 2010. Methods 6126 respondents were administered selected modules of the Composite International Diagnostic Interview, to assess major depressive disorder (MDD), dysthymia, bipolar disorder, generalized anxiety disorder (GAD), obsessive compulsive disorder (OCD) and alcohol use disorder (AUD) (which included alcohol abuse and dependence). Past year treatment gap was defined as the absolute difference between the prevalence of a particular mental disorder in the past 12 months preceding the interview and those who had received treatment for that disorder. Results The prevalence of overall 12-month treatment gap in this population was high (78.6%). A multiple logistic regression analysis revealed significantly higher odds of treatment gap among those diagnosed with OCD (compared to those with MDD) and in those with a comorbid chronic physical disorder; while those who had primary education and below and those who were unemployed were less likely to have a treatment gap as compared to those with post-secondary education and those employed, respectively. Conclusions The high treatment gap in the population is concerning and highlights the need to promote help-seeking and uptake of treatment. Given the unique demographic characteristics, i.e., those with higher education and employed were more likely not to seek treatment, targeted interventions in the educational and workplace settings should be implemented.</description><subject>Alcohol</subject><subject>Alcohol abuse</subject><subject>Alcohol use</subject><subject>Analysis</subject><subject>Anxiety</subject><subject>Bipolar disorder</subject><subject>Care and treatment</subject><subject>Demographics</subject><subject>Dependence</subject><subject>Diagnostic systems</subject><subject>Education</subject><subject>Epidemiology</subject><subject>Health surveys</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Obsessive compulsive disorder</subject><subject>Original Paper</subject><subject>Psychiatry</subject><subject>Regression analysis</subject><subject>Substance abuse</subject><subject>Surveys</subject><issn>0933-7954</issn><issn>1433-9285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kk1v1DAQhi0EosvCH-CAInHhkuLPOOaAVFXQVmrFoXC2Jo6TdZXEi51U6r9ntltaWqFqFMXJPPN6xn4Jec_oIaNUf86UMq5Lygw-WtYlfUFWTApRGl6rl2RFDa61UfKAvMn5ilIqjBavyYFggmkuqxU5uQhTG6a-mDe-mJOHefTTXPSw_VIkn5dhzkXsbrOXiME2Jl9cIAJDcephmDfF5by0N2_Jqw6G7N_dvdfk1_dvP49Py_MfJ2fHR-elU5WZy865lvGGssYZT2sQNYDsQOFn20HVaC2NdHXVMFU7s2uYKwoAOKeqeKXEmnzd626XZvStw04SDHabwgjpxkYI9nFmChvbx2urla4Zlyjw6U4gxd-Lz7MdQ3Z-GGDyccmWc2UM53VVIfrxCXoVlzTheJZLzRQGZc9SqMWY0JI_UD0M3oapi9id221tjzSr8NIYXtaaHP6Hwmj9GFycfBfw_6MCvi9wKeacfHd_EozanUns3iQWTWJvTWIpFn349wzvS_66AgGxBzKmpt6nh5Gekf0D5LrEkQ</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Subramaniam, Mythily</creator><creator>Abdin, Edimansyah</creator><creator>Vaingankar, Janhavi Ajit</creator><creator>Shafie, Saleha</creator><creator>Chua, Hong Choon</creator><creator>Tan, Weng Mooi</creator><creator>Tan, Kelvin Bryan</creator><creator>Verma, Swapna</creator><creator>Heng, Derrick</creator><creator>Chong, Siow Ann</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4530-1096</orcidid></search><sort><creationdate>20201101</creationdate><title>Minding the treatment gap: results of the Singapore Mental Health Study</title><author>Subramaniam, Mythily ; Abdin, Edimansyah ; Vaingankar, Janhavi Ajit ; Shafie, Saleha ; Chua, Hong Choon ; Tan, Weng Mooi ; Tan, Kelvin Bryan ; Verma, Swapna ; Heng, Derrick ; Chong, Siow Ann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-fccd12b01bc9e08a38aa4fa5bc9dfa6b77494c86b158c90003250aaa127562653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alcohol</topic><topic>Alcohol abuse</topic><topic>Alcohol use</topic><topic>Analysis</topic><topic>Anxiety</topic><topic>Bipolar disorder</topic><topic>Care and treatment</topic><topic>Demographics</topic><topic>Dependence</topic><topic>Diagnostic systems</topic><topic>Education</topic><topic>Epidemiology</topic><topic>Health surveys</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Mental disorders</topic><topic>Mental health</topic><topic>Obsessive compulsive disorder</topic><topic>Original Paper</topic><topic>Psychiatry</topic><topic>Regression analysis</topic><topic>Substance abuse</topic><topic>Surveys</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Subramaniam, Mythily</creatorcontrib><creatorcontrib>Abdin, Edimansyah</creatorcontrib><creatorcontrib>Vaingankar, Janhavi Ajit</creatorcontrib><creatorcontrib>Shafie, Saleha</creatorcontrib><creatorcontrib>Chua, Hong Choon</creatorcontrib><creatorcontrib>Tan, Weng Mooi</creatorcontrib><creatorcontrib>Tan, Kelvin Bryan</creatorcontrib><creatorcontrib>Verma, Swapna</creatorcontrib><creatorcontrib>Heng, Derrick</creatorcontrib><creatorcontrib>Chong, Siow Ann</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database (ProQuest)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Social Psychiatry and Psychiatric Epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Subramaniam, Mythily</au><au>Abdin, Edimansyah</au><au>Vaingankar, Janhavi Ajit</au><au>Shafie, Saleha</au><au>Chua, Hong Choon</au><au>Tan, Weng Mooi</au><au>Tan, Kelvin Bryan</au><au>Verma, Swapna</au><au>Heng, Derrick</au><au>Chong, Siow Ann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Minding the treatment gap: results of the Singapore Mental Health Study</atitle><jtitle>Social Psychiatry and Psychiatric Epidemiology</jtitle><stitle>Soc Psychiatry Psychiatr Epidemiol</stitle><addtitle>Soc Psychiatry Psychiatr Epidemiol</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>55</volume><issue>11</issue><spage>1415</spage><epage>1424</epage><pages>1415-1424</pages><issn>0933-7954</issn><eissn>1433-9285</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Purpose To establish the 12-month treatment gap and its associated factors among adults with mental disorders in the Singapore resident population using data from the second Singapore Mental Health Study and to examine the changes since the last mental health survey conducted in 2010. Methods 6126 respondents were administered selected modules of the Composite International Diagnostic Interview, to assess major depressive disorder (MDD), dysthymia, bipolar disorder, generalized anxiety disorder (GAD), obsessive compulsive disorder (OCD) and alcohol use disorder (AUD) (which included alcohol abuse and dependence). Past year treatment gap was defined as the absolute difference between the prevalence of a particular mental disorder in the past 12 months preceding the interview and those who had received treatment for that disorder. Results The prevalence of overall 12-month treatment gap in this population was high (78.6%). A multiple logistic regression analysis revealed significantly higher odds of treatment gap among those diagnosed with OCD (compared to those with MDD) and in those with a comorbid chronic physical disorder; while those who had primary education and below and those who were unemployed were less likely to have a treatment gap as compared to those with post-secondary education and those employed, respectively. Conclusions The high treatment gap in the population is concerning and highlights the need to promote help-seeking and uptake of treatment. Given the unique demographic characteristics, i.e., those with higher education and employed were more likely not to seek treatment, targeted interventions in the educational and workplace settings should be implemented.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31317246</pmid><doi>10.1007/s00127-019-01748-0</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4530-1096</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0933-7954
ispartof Social Psychiatry and Psychiatric Epidemiology, 2020-11, Vol.55 (11), p.1415-1424
issn 0933-7954
1433-9285
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7578124
source Springer Link
subjects Alcohol
Alcohol abuse
Alcohol use
Analysis
Anxiety
Bipolar disorder
Care and treatment
Demographics
Dependence
Diagnostic systems
Education
Epidemiology
Health surveys
Medicine
Medicine & Public Health
Mental disorders
Mental health
Obsessive compulsive disorder
Original Paper
Psychiatry
Regression analysis
Substance abuse
Surveys
title Minding the treatment gap: results of the Singapore Mental Health Study
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T17%3A14%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Minding%20the%20treatment%20gap:%20results%20of%20the%20Singapore%20Mental%20Health%20Study&rft.jtitle=Social%20Psychiatry%20and%20Psychiatric%20Epidemiology&rft.au=Subramaniam,%20Mythily&rft.date=2020-11-01&rft.volume=55&rft.issue=11&rft.spage=1415&rft.epage=1424&rft.pages=1415-1424&rft.issn=0933-7954&rft.eissn=1433-9285&rft_id=info:doi/10.1007/s00127-019-01748-0&rft_dat=%3Cgale_pubme%3EA716433193%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c569t-fccd12b01bc9e08a38aa4fa5bc9dfa6b77494c86b158c90003250aaa127562653%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2259113742&rft_id=info:pmid/31317246&rft_galeid=A716433193&rfr_iscdi=true