Effect of maternal preconceptional and pregnancy micronutrient interventions on children’s DNA methylation: Findings from the EMPHASIS study

Maternal nutrition in pregnancy has been linked to offspring health in early and later life, with changes to DNA methylation (DNAm) proposed as a mediating mechanism. We investigated intervention-associated DNAm changes in children whose mothers participated in 2 randomized controlled trials of micr...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of clinical nutrition 2020-10, Vol.112 (4), p.1099-1113
Main Authors: Saffari, Ayden, Shrestha, Smeeta, Issarapu, Prachand, Sajjadi, Sara, Betts, Modupeh, Sahariah, Sirazul Ameen, Tomar, Ashutosh Singh, James, Philip, Dedaniya, Akshay, Yadav, Dilip K, Kumaran, Kalyanaraman, Prentice, Andrew M, Lillycrop, Karen A, Fall, Caroline HD, Chandak, Giriraj R, Silver, Matt J
Format: Article
Language:English
Subjects:
Adult
Arrays
Child
Child, Preschool
Children
CpG islands
Deoxyribonucleic acid
Dietary supplements
DNA
DNA Methylation
Embryos
Epigenetics
epigenome-wide association study
Female
Gene-Environment Interaction
Human nutrition
Humans
Intervention
Loci
Male
Mapping
Maternal Nutritional Physiological Phenomena
micronutrient intervention
Micronutrients - administration & dosage
Neoplasm Proteins - genetics
Nutrition
Offspring
Original Research Communications
Pregnancy
Proteoglycans - genetics
Quantitative Trait Loci
Randomized Controlled Trials as Topic
RCT
Regional analysis
Regional planning
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Maternal nutrition in pregnancy has been linked to offspring health in early and later life, with changes to DNA methylation (DNAm) proposed as a mediating mechanism. We investigated intervention-associated DNAm changes in children whose mothers participated in 2 randomized controlled trials of micronutrient supplementation before and during pregnancy, as part of the EMPHASIS (Epigenetic Mechanisms linking Preconceptional nutrition and Health Assessed in India and sub-Saharan Africa) study (ISRCTN14266771). We conducted epigenome-wide association studies with blood samples from Indian (n = 698) and Gambian (n = 293) children using the Illumina EPIC array and a targeted study of selected loci not on the array. The Indian micronutrient intervention was food based, whereas the Gambian intervention was a micronutrient tablet. We identified 6 differentially methylated CpGs in Gambians [2.5–5.0% reduction in intervention group, all false discovery rate (FDR)
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/nqaa193