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Cefazolin and Ertapenem Salvage Therapy Rapidly Clears Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia
Abstract Cefazolin and ertapenem combination therapy was used successfully to salvage 11 cases (6 endocarditis) of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, including immediate clearance (≤24 hours) in 8 cases. While in vitro synergy was modest, cefazolin plus ertap...
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Published in: | Clinical infectious diseases 2020-09, Vol.71 (6), p.1413-1418 |
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container_title | Clinical infectious diseases |
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creator | Ulloa, Erlinda R Singh, Kavindra V Geriak, Matthew Haddad, Fadi Murray, Barbara E Nizet, Victor Sakoulas, George |
description | Abstract
Cefazolin and ertapenem combination therapy was used successfully to salvage 11 cases (6 endocarditis) of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, including immediate clearance (≤24 hours) in 8 cases. While in vitro synergy was modest, cefazolin plus ertapenem exhibited synergistic action in a rat model of MSSA endocarditis. The combination of cefazolin and ertapenem provides potent in vivo activity against MSSA beyond what is predicted in vitro and warrants further clinical study in the treatment of refractory MSSA bacteremia and endocarditis.
Cefazolin and ertapenem combination therapy yielded profound clinical success in 11 severe methicillin-susceptible Staphylococcus aureus infections with high bacterial densities (6 endocarditis), as demonstrated by rapid bacteremia clearance. Enhanced efficacy was also observed in a rat endocarditis model. |
doi_str_mv | 10.1093/cid/ciz995 |
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Cefazolin and ertapenem combination therapy was used successfully to salvage 11 cases (6 endocarditis) of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, including immediate clearance (≤24 hours) in 8 cases. While in vitro synergy was modest, cefazolin plus ertapenem exhibited synergistic action in a rat model of MSSA endocarditis. The combination of cefazolin and ertapenem provides potent in vivo activity against MSSA beyond what is predicted in vitro and warrants further clinical study in the treatment of refractory MSSA bacteremia and endocarditis.
Cefazolin and ertapenem combination therapy yielded profound clinical success in 11 severe methicillin-susceptible Staphylococcus aureus infections with high bacterial densities (6 endocarditis), as demonstrated by rapid bacteremia clearance. Enhanced efficacy was also observed in a rat endocarditis model.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciz995</identifier><identifier>PMID: 31773134</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>and Commentaries ; Animals ; Anti-Bacterial Agents - therapeutic use ; Bacteremia - drug therapy ; Cefazolin - therapeutic use ; Ertapenem ; Methicillin - pharmacology ; Rats ; Salvage Therapy ; Staphylococcal Infections - drug therapy ; Staphylococcus aureus</subject><ispartof>Clinical infectious diseases, 2020-09, Vol.71 (6), p.1413-1418</ispartof><rights>The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-51c989f08f092be687fbc7da3850ee5f92fe134ef71f2d5d1fc4239f814872423</citedby><cites>FETCH-LOGICAL-c408t-51c989f08f092be687fbc7da3850ee5f92fe134ef71f2d5d1fc4239f814872423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,1591,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31773134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ulloa, Erlinda R</creatorcontrib><creatorcontrib>Singh, Kavindra V</creatorcontrib><creatorcontrib>Geriak, Matthew</creatorcontrib><creatorcontrib>Haddad, Fadi</creatorcontrib><creatorcontrib>Murray, Barbara E</creatorcontrib><creatorcontrib>Nizet, Victor</creatorcontrib><creatorcontrib>Sakoulas, George</creatorcontrib><title>Cefazolin and Ertapenem Salvage Therapy Rapidly Clears Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Abstract
Cefazolin and ertapenem combination therapy was used successfully to salvage 11 cases (6 endocarditis) of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, including immediate clearance (≤24 hours) in 8 cases. While in vitro synergy was modest, cefazolin plus ertapenem exhibited synergistic action in a rat model of MSSA endocarditis. The combination of cefazolin and ertapenem provides potent in vivo activity against MSSA beyond what is predicted in vitro and warrants further clinical study in the treatment of refractory MSSA bacteremia and endocarditis.
Cefazolin and ertapenem combination therapy yielded profound clinical success in 11 severe methicillin-susceptible Staphylococcus aureus infections with high bacterial densities (6 endocarditis), as demonstrated by rapid bacteremia clearance. Enhanced efficacy was also observed in a rat endocarditis model.</description><subject>and Commentaries</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacteremia - drug therapy</subject><subject>Cefazolin - therapeutic use</subject><subject>Ertapenem</subject><subject>Methicillin - pharmacology</subject><subject>Rats</subject><subject>Salvage Therapy</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcus aureus</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kVFrFDEQx4MotlZf_ACSF0GE1WSz2U1eBD1aLVQUrz6HueykF8lu1mS3cPfpm3K11Jc-hBnIj9_M8CfkNWcfONPio_V9eXut5RNyzKXoqlZq_rT0TKqqUUIdkRc5_2GMc8Xkc3IkeNcJLppjsl-hg30MfqQw9vQ0zTDhiANdQ7iGK6SXW0ww7egvmHwfdnQVEFKmPzFln2ccZ_od5623PhRHtV6yxWn2m4B0XVTbXYg2WrtkCkvCUr6AnTHh4OEleeYgZHx1V0_I77PTy9W36uLH1_PV54vKNkzNleRWK-2YckzXG2xV5za260EoyRCl07XDcgq6jru6lz13tqmFdoo3qqtLe0I-HbzTshmwt2XnBMFMyQ-QdiaCN___jH5rruK16RrVliFF8O5OkOLfBfNsBl_ODAFGjEs2teCaa9G2vKDvD6hNMeeE7n4MZ-Y2LFPCMoewCvzm4WL36L90CvD2AMRlekx0A2M0oWc</recordid><startdate>20200912</startdate><enddate>20200912</enddate><creator>Ulloa, Erlinda R</creator><creator>Singh, Kavindra V</creator><creator>Geriak, Matthew</creator><creator>Haddad, Fadi</creator><creator>Murray, Barbara E</creator><creator>Nizet, Victor</creator><creator>Sakoulas, George</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200912</creationdate><title>Cefazolin and Ertapenem Salvage Therapy Rapidly Clears Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia</title><author>Ulloa, Erlinda R ; Singh, Kavindra V ; Geriak, Matthew ; Haddad, Fadi ; Murray, Barbara E ; Nizet, Victor ; Sakoulas, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-51c989f08f092be687fbc7da3850ee5f92fe134ef71f2d5d1fc4239f814872423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>and Commentaries</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacteremia - drug therapy</topic><topic>Cefazolin - therapeutic use</topic><topic>Ertapenem</topic><topic>Methicillin - pharmacology</topic><topic>Rats</topic><topic>Salvage Therapy</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcus aureus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ulloa, Erlinda R</creatorcontrib><creatorcontrib>Singh, Kavindra V</creatorcontrib><creatorcontrib>Geriak, Matthew</creatorcontrib><creatorcontrib>Haddad, Fadi</creatorcontrib><creatorcontrib>Murray, Barbara E</creatorcontrib><creatorcontrib>Nizet, Victor</creatorcontrib><creatorcontrib>Sakoulas, George</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ulloa, Erlinda R</au><au>Singh, Kavindra V</au><au>Geriak, Matthew</au><au>Haddad, Fadi</au><au>Murray, Barbara E</au><au>Nizet, Victor</au><au>Sakoulas, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cefazolin and Ertapenem Salvage Therapy Rapidly Clears Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2020-09-12</date><risdate>2020</risdate><volume>71</volume><issue>6</issue><spage>1413</spage><epage>1418</epage><pages>1413-1418</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Abstract
Cefazolin and ertapenem combination therapy was used successfully to salvage 11 cases (6 endocarditis) of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, including immediate clearance (≤24 hours) in 8 cases. While in vitro synergy was modest, cefazolin plus ertapenem exhibited synergistic action in a rat model of MSSA endocarditis. The combination of cefazolin and ertapenem provides potent in vivo activity against MSSA beyond what is predicted in vitro and warrants further clinical study in the treatment of refractory MSSA bacteremia and endocarditis.
Cefazolin and ertapenem combination therapy yielded profound clinical success in 11 severe methicillin-susceptible Staphylococcus aureus infections with high bacterial densities (6 endocarditis), as demonstrated by rapid bacteremia clearance. Enhanced efficacy was also observed in a rat endocarditis model.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>31773134</pmid><doi>10.1093/cid/ciz995</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | and Commentaries Animals Anti-Bacterial Agents - therapeutic use Bacteremia - drug therapy Cefazolin - therapeutic use Ertapenem Methicillin - pharmacology Rats Salvage Therapy Staphylococcal Infections - drug therapy Staphylococcus aureus |
title | Cefazolin and Ertapenem Salvage Therapy Rapidly Clears Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia |
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