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Dimension- and context-specific expression of preschoolers' disruptive behaviors associated with prenatal tobacco exposure
Precise phenotypic characterization of prenatal tobacco exposure (PTE)–related disruptive behavior (DB) that integrates nuanced measures of both exposures and outcomes is optimal for elucidating underlying mechanisms. Using this approach, our goals were to identify dimensions of DB most sensitive to...
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| Published in: | Neurotoxicology and teratology 2020-09, Vol.81, p.106915-106915, Article 106915 |
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| creator | Massey, Suena H. Clark, Caron A.C. Sun, Michael Y. Burns, James L. Mroczek, Daniel K. Espy, Kimberly A. Wakschlag, Lauren S. |
| description | Precise phenotypic characterization of prenatal tobacco exposure (PTE)–related disruptive behavior (DB) that integrates nuanced measures of both exposures and outcomes is optimal for elucidating underlying mechanisms. Using this approach, our goals were to identify dimensions of DB most sensitive to PTE prior to school entry and assess contextual variation in these dimensions.
A community obstetric sample of N = 369 women (79.2% lifetime smokers; 70.2% pregnancy smokers) from two Midwestern cities were assessed for PTE using cotinine-calibrated interview-based reports at 16, 28, and 40 weeks of gestation. A subset of n = 244 who completed observational assessments with their 5-year-old children in a subsequent preschool follow-up study constitute the analytic sample. Using two developmentally-meaningful dimensions previously associated with emergent clinical risk for DB—irritability and noncompliance—we assessed children with 2 parent-report scales: the Multidimensional Assessment Profile of Disruptive Behavior (MAP-DB) and the Early Childhood Inventory (ECI). We also assessed children by direct observation across 3 interactional contexts with the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS). We used generalized linear models to examine between-child variability across behavioral dimensions, and mixed effects models to examine directly observed within-child variability by interactional context.
Increasing PTE predicted increasing impairment in preschoolers' modulation of negative affect (irritability), but not negative behavior (noncompliance) across reported (MAP-DB) and observed (DB-DOS) dimensional measures. Moreover, children's PTE-related irritability was more pronounced when observed with parents than with the examiner. The ECI did not detect PTE-related irritability nor noncompliance.
Nuanced, dimension- and context-specific characterization of PTE-related DB described can optimize early identification of at-risk children.
•Understanding mechanisms linking prenatal tobacco exposure (PTE) with disruptive behavior (DB) requires improved measures.•We combined bioassay-corrected PTE with developmentally sensitive, context-sensitive DB assessment.•PTE showed a dose-dependent association with preschoolers’ irritability in parent, but not examiner contexts.•PTE-related effects were not detected by a commonly used symptom-based measure.•Nuanced, developmentally informed, context-sensitive measures are critical to the clear specification of P |
| doi_str_mv | 10.1016/j.ntt.2020.106915 |
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A community obstetric sample of N = 369 women (79.2% lifetime smokers; 70.2% pregnancy smokers) from two Midwestern cities were assessed for PTE using cotinine-calibrated interview-based reports at 16, 28, and 40 weeks of gestation. A subset of n = 244 who completed observational assessments with their 5-year-old children in a subsequent preschool follow-up study constitute the analytic sample. Using two developmentally-meaningful dimensions previously associated with emergent clinical risk for DB—irritability and noncompliance—we assessed children with 2 parent-report scales: the Multidimensional Assessment Profile of Disruptive Behavior (MAP-DB) and the Early Childhood Inventory (ECI). We also assessed children by direct observation across 3 interactional contexts with the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS). We used generalized linear models to examine between-child variability across behavioral dimensions, and mixed effects models to examine directly observed within-child variability by interactional context.
Increasing PTE predicted increasing impairment in preschoolers' modulation of negative affect (irritability), but not negative behavior (noncompliance) across reported (MAP-DB) and observed (DB-DOS) dimensional measures. Moreover, children's PTE-related irritability was more pronounced when observed with parents than with the examiner. The ECI did not detect PTE-related irritability nor noncompliance.
Nuanced, dimension- and context-specific characterization of PTE-related DB described can optimize early identification of at-risk children.
•Understanding mechanisms linking prenatal tobacco exposure (PTE) with disruptive behavior (DB) requires improved measures.•We combined bioassay-corrected PTE with developmentally sensitive, context-sensitive DB assessment.•PTE showed a dose-dependent association with preschoolers’ irritability in parent, but not examiner contexts.•PTE-related effects were not detected by a commonly used symptom-based measure.•Nuanced, developmentally informed, context-sensitive measures are critical to the clear specification of PTE’s effects.•Nuanced, developmentally informed and context-sensitive measures are critical to the clear specification of PTE’s effects.</description><identifier>ISSN: 0892-0362</identifier><identifier>EISSN: 1872-9738</identifier><identifier>DOI: 10.1016/j.ntt.2020.106915</identifier><identifier>PMID: 32693011</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Attention Deficit and Disruptive Behavior Disorders - psychology ; Child ; Child, Preschool ; Disruptive behaviors ; Early childhood ; Female ; Humans ; Male ; Nicotiana - adverse effects ; Oppositional defiant disorder ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prenatal tobacco exposure ; Problem Behavior - psychology ; Psychiatric Status Rating Scales ; Smoking during pregnancy ; Tobacco Use - adverse effects</subject><ispartof>Neurotoxicology and teratology, 2020-09, Vol.81, p.106915-106915, Article 106915</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-46abcef438d33a6326073cc1f24a45daa8c9f0d6e37a85080607943939e15ce03</citedby><cites>FETCH-LOGICAL-c451t-46abcef438d33a6326073cc1f24a45daa8c9f0d6e37a85080607943939e15ce03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32693011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Massey, Suena H.</creatorcontrib><creatorcontrib>Clark, Caron A.C.</creatorcontrib><creatorcontrib>Sun, Michael Y.</creatorcontrib><creatorcontrib>Burns, James L.</creatorcontrib><creatorcontrib>Mroczek, Daniel K.</creatorcontrib><creatorcontrib>Espy, Kimberly A.</creatorcontrib><creatorcontrib>Wakschlag, Lauren S.</creatorcontrib><title>Dimension- and context-specific expression of preschoolers' disruptive behaviors associated with prenatal tobacco exposure</title><title>Neurotoxicology and teratology</title><addtitle>Neurotoxicol Teratol</addtitle><description>Precise phenotypic characterization of prenatal tobacco exposure (PTE)–related disruptive behavior (DB) that integrates nuanced measures of both exposures and outcomes is optimal for elucidating underlying mechanisms. Using this approach, our goals were to identify dimensions of DB most sensitive to PTE prior to school entry and assess contextual variation in these dimensions.
A community obstetric sample of N = 369 women (79.2% lifetime smokers; 70.2% pregnancy smokers) from two Midwestern cities were assessed for PTE using cotinine-calibrated interview-based reports at 16, 28, and 40 weeks of gestation. A subset of n = 244 who completed observational assessments with their 5-year-old children in a subsequent preschool follow-up study constitute the analytic sample. Using two developmentally-meaningful dimensions previously associated with emergent clinical risk for DB—irritability and noncompliance—we assessed children with 2 parent-report scales: the Multidimensional Assessment Profile of Disruptive Behavior (MAP-DB) and the Early Childhood Inventory (ECI). We also assessed children by direct observation across 3 interactional contexts with the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS). We used generalized linear models to examine between-child variability across behavioral dimensions, and mixed effects models to examine directly observed within-child variability by interactional context.
Increasing PTE predicted increasing impairment in preschoolers' modulation of negative affect (irritability), but not negative behavior (noncompliance) across reported (MAP-DB) and observed (DB-DOS) dimensional measures. Moreover, children's PTE-related irritability was more pronounced when observed with parents than with the examiner. The ECI did not detect PTE-related irritability nor noncompliance.
Nuanced, dimension- and context-specific characterization of PTE-related DB described can optimize early identification of at-risk children.
•Understanding mechanisms linking prenatal tobacco exposure (PTE) with disruptive behavior (DB) requires improved measures.•We combined bioassay-corrected PTE with developmentally sensitive, context-sensitive DB assessment.•PTE showed a dose-dependent association with preschoolers’ irritability in parent, but not examiner contexts.•PTE-related effects were not detected by a commonly used symptom-based measure.•Nuanced, developmentally informed, context-sensitive measures are critical to the clear specification of PTE’s effects.•Nuanced, developmentally informed and context-sensitive measures are critical to the clear specification of PTE’s effects.</description><subject>Attention Deficit and Disruptive Behavior Disorders - psychology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disruptive behaviors</subject><subject>Early childhood</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Nicotiana - adverse effects</subject><subject>Oppositional defiant disorder</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prenatal tobacco exposure</subject><subject>Problem Behavior - psychology</subject><subject>Psychiatric Status Rating Scales</subject><subject>Smoking during pregnancy</subject><subject>Tobacco Use - adverse effects</subject><issn>0892-0362</issn><issn>1872-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU9vEzEQxa0K1KalH4AL8o3TBnu9f2whIaECBakSFzhbk_Fs4yixV7aTtnx6dpW2ohdOHmve-409j7G3UiylkN2HzTKUsqxFPd87I9sTtpC6ryvTK_2KLYQ2dSVUV5-x85w3Qoi-k-KUnam6M0pIuWB_vvgdhexjqDgExzGGQvelyiOhHzxyuh8T5VnA48DnGtcxbinl99z5nPZj8QfiK1rDwceUOeQc0UMhx-98Wc-WAAW2vMQVIMaZGPM-0Rv2eoBtpsvH84L9_vb119X36ubn9Y-rzzcVNq0sVdPBCmlolHZKQTc9XfQKUQ51A03rADSaQbiOVA-6FVpMfdMoowzJFkmoC_bpyB33qx05pFASbO2Y_A7Sg43g7ctO8Gt7Gw-2b3RjtJwA8gjAFHNONDx7pbBzEHZjpyDsHIQ9BjF53v079NnxtPlJ8PEooOnrB0_JZvQUkJxPhMW66P-D_wsscZ3B</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Massey, Suena H.</creator><creator>Clark, Caron A.C.</creator><creator>Sun, Michael Y.</creator><creator>Burns, James L.</creator><creator>Mroczek, Daniel K.</creator><creator>Espy, Kimberly A.</creator><creator>Wakschlag, Lauren S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20200901</creationdate><title>Dimension- and context-specific expression of preschoolers' disruptive behaviors associated with prenatal tobacco exposure</title><author>Massey, Suena H. ; Clark, Caron A.C. ; Sun, Michael Y. ; Burns, James L. ; Mroczek, Daniel K. ; Espy, Kimberly A. ; Wakschlag, Lauren S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-46abcef438d33a6326073cc1f24a45daa8c9f0d6e37a85080607943939e15ce03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Attention Deficit and Disruptive Behavior Disorders - psychology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disruptive behaviors</topic><topic>Early childhood</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Nicotiana - adverse effects</topic><topic>Oppositional defiant disorder</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Prenatal tobacco exposure</topic><topic>Problem Behavior - psychology</topic><topic>Psychiatric Status Rating Scales</topic><topic>Smoking during pregnancy</topic><topic>Tobacco Use - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Massey, Suena H.</creatorcontrib><creatorcontrib>Clark, Caron A.C.</creatorcontrib><creatorcontrib>Sun, Michael Y.</creatorcontrib><creatorcontrib>Burns, James L.</creatorcontrib><creatorcontrib>Mroczek, Daniel K.</creatorcontrib><creatorcontrib>Espy, Kimberly A.</creatorcontrib><creatorcontrib>Wakschlag, Lauren S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurotoxicology and teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Massey, Suena H.</au><au>Clark, Caron A.C.</au><au>Sun, Michael Y.</au><au>Burns, James L.</au><au>Mroczek, Daniel K.</au><au>Espy, Kimberly A.</au><au>Wakschlag, Lauren S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dimension- and context-specific expression of preschoolers' disruptive behaviors associated with prenatal tobacco exposure</atitle><jtitle>Neurotoxicology and teratology</jtitle><addtitle>Neurotoxicol Teratol</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>81</volume><spage>106915</spage><epage>106915</epage><pages>106915-106915</pages><artnum>106915</artnum><issn>0892-0362</issn><eissn>1872-9738</eissn><abstract>Precise phenotypic characterization of prenatal tobacco exposure (PTE)–related disruptive behavior (DB) that integrates nuanced measures of both exposures and outcomes is optimal for elucidating underlying mechanisms. Using this approach, our goals were to identify dimensions of DB most sensitive to PTE prior to school entry and assess contextual variation in these dimensions.
A community obstetric sample of N = 369 women (79.2% lifetime smokers; 70.2% pregnancy smokers) from two Midwestern cities were assessed for PTE using cotinine-calibrated interview-based reports at 16, 28, and 40 weeks of gestation. A subset of n = 244 who completed observational assessments with their 5-year-old children in a subsequent preschool follow-up study constitute the analytic sample. Using two developmentally-meaningful dimensions previously associated with emergent clinical risk for DB—irritability and noncompliance—we assessed children with 2 parent-report scales: the Multidimensional Assessment Profile of Disruptive Behavior (MAP-DB) and the Early Childhood Inventory (ECI). We also assessed children by direct observation across 3 interactional contexts with the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS). We used generalized linear models to examine between-child variability across behavioral dimensions, and mixed effects models to examine directly observed within-child variability by interactional context.
Increasing PTE predicted increasing impairment in preschoolers' modulation of negative affect (irritability), but not negative behavior (noncompliance) across reported (MAP-DB) and observed (DB-DOS) dimensional measures. Moreover, children's PTE-related irritability was more pronounced when observed with parents than with the examiner. The ECI did not detect PTE-related irritability nor noncompliance.
Nuanced, dimension- and context-specific characterization of PTE-related DB described can optimize early identification of at-risk children.
•Understanding mechanisms linking prenatal tobacco exposure (PTE) with disruptive behavior (DB) requires improved measures.•We combined bioassay-corrected PTE with developmentally sensitive, context-sensitive DB assessment.•PTE showed a dose-dependent association with preschoolers’ irritability in parent, but not examiner contexts.•PTE-related effects were not detected by a commonly used symptom-based measure.•Nuanced, developmentally informed, context-sensitive measures are critical to the clear specification of PTE’s effects.•Nuanced, developmentally informed and context-sensitive measures are critical to the clear specification of PTE’s effects.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32693011</pmid><doi>10.1016/j.ntt.2020.106915</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Attention Deficit and Disruptive Behavior Disorders - psychology Child Child, Preschool Disruptive behaviors Early childhood Female Humans Male Nicotiana - adverse effects Oppositional defiant disorder Pregnancy Prenatal Exposure Delayed Effects Prenatal tobacco exposure Problem Behavior - psychology Psychiatric Status Rating Scales Smoking during pregnancy Tobacco Use - adverse effects |
| title | Dimension- and context-specific expression of preschoolers' disruptive behaviors associated with prenatal tobacco exposure |
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