Clot Burden Score and Early Ischemia Predict Intracranial Hemorrhage following Endovascular Therapy

Intracranial hemorrhage is a known complication following endovascular thrombectomy. The radiologic characteristics of a CT scan may assist with hemorrhage risk stratification. We assessed the radiologic predictors of intracranial hemorrhage following endovascular therapy using data from the INTERRS...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2019-04, Vol.40 (4), p.655-660
Main Authors: Yogendrakumar, V, Al-Ajlan, F, Najm, M, Puig, J, Calleja, A, Sohn, S-I, Ahn, S H, Mikulik, R, Asdaghi, N, Field, T S, Jin, A, Asil, T, Boulanger, J-M, Hill, M D, Demchuk, A M, Menon, B K, Dowlatshahi, D
Format: Article
Language:English
Subjects:
Aged
Brain Ischemia - pathology
Endovascular Procedures - adverse effects
Female
Humans
Interventional
Intracranial Hemorrhages - etiology
Male
Middle Aged
Risk Factors
Stroke - pathology
Stroke - therapy
Thrombectomy - adverse effects
Thrombosis - pathology
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Summary:Intracranial hemorrhage is a known complication following endovascular thrombectomy. The radiologic characteristics of a CT scan may assist with hemorrhage risk stratification. We assessed the radiologic predictors of intracranial hemorrhage following endovascular therapy using data from the INTERRSeCT (Identifying New Approaches to Optimize Thrombus Characterization for Predicting Early Recanalization and Reperfusion With IV Alteplase and Other Treatments Using Serial CT Angiography) study. Patients undergoing endovascular therapy underwent baseline imaging, postprocedural angiography, and 24-hour follow-up imaging. The primary outcome was any intracranial hemorrhage observed on follow-up imaging. The secondary outcome was symptomatic hemorrhage. We assessed the relationship between hemorrhage occurrence and baseline patient characteristics, clinical course, and imaging factors: baseline ASPECTS, thrombus location, residual flow grade, collateralization, and clot burden score. Multivariable logistic regression with backward selection was used to adjust for relevant covariates. Of the 199 enrolled patients who met the inclusion criteria, 46 (23%) had an intracranial hemorrhage at 24 hours. On multivariable analysis, postprocedural hemorrhage was associated with pretreatment ASPECTS (OR, 1.56 per point lost; 95% CI, 1.12-2.15), clot burden score (OR, 1.19 per point lost; 95% CI, 1.03-1.38), and ICA thrombus location (OR, 3.10; 95% CI, 1.07-8.91). In post hoc analysis, clot burden scores of ≤3 (sensitivity, 41%; specificity, 82%; OR, 3.12; 95% CI, 1.36-7.15) and pretreatment ASPECTS ≤ 7 (sensitivity, 48%; specificity, 82%; OR, 3.17; 95% CI, 1.35-7.45) robustly predicted hemorrhage. Residual flow grade and collateralization were not associated with hemorrhage occurrence. Symptomatic hemorrhage was observed in 4 patients. Radiologic factors, early ischemia on CT, and increased CTA clot burden are associated with an increased risk of intracranial hemorrhage in patients undergoing endovascular therapy.
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.A6009